Synthesis of Chlorin–(Arylamino)quinazoline Hybrids as Models for Multifunctional Drug Development

Abstract

A series of multifunctional conjugates each consisting of a fluorescent chlorin photosensitizer and an (arylamino)quinazoline-based epidermal growth factor receptor/vascular endothelial growth factor receptor ligand, potentially useful in site-selective photodynamic antitumor therapy, were prepared and their photochemical properties were investigated.

Key words

porphyrins - cycloaddition - alkynes - azides - click chemistry - medicinal chemistry

• References

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