A Study of Aerobic Photooxidation with a Continuous-Flow Microreactor

Yoshitomo Nagasawa; Katsuya Tanba; Norihiro Tada; Eiji Yamaguchi; Akichika Itoh

doi:10.1055/s-0034-1379698

Synlett, Inhaltsverzeichnis

Synlett 2015; 26(03): 412-415
DOI: 10.1055/s-0034-1379698

letter

A Study of Aerobic Photooxidation with a Continuous-Flow Microreactor

Authors

Yoshitomo Nagasawa

^aGifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan eMail: itoha@gifu-pu.ac.jp
Katsuya Tanba

^bDexerials Corporation, 30 Kaganosakai, Takaraeniida, Nakada-cho, Tome-shi, Miyagi, 987-0622, Japan
Norihiro Tada

^aGifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan eMail: itoha@gifu-pu.ac.jp
Eiji Yamaguchi

^aGifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan eMail: itoha@gifu-pu.ac.jp
Akichika Itoh*

^aGifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan eMail: itoha@gifu-pu.ac.jp

Abstract

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Abstract

We report the development of an aerobic photooxidation process with a continuous-flow microreactor that can form a slug flow region on the chip. The approach solved several problems raised by using batch systems.

Key words

oxygen - photooxidation - green chemistry - microreactor - slug flow

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Referenzen

References and Notes
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11 Typical Procedure with Flow Microreactor: A solution of the substrate (0.3 mmol) and photosensitizer (0.1 equiv) in EtOAc (0.6 mL) was introduced into one of the channels by using a syringe pump. Simultaneously, molecular oxygen (0.1 MPa) was introduced into the second channel from a gas cylinder controlled by a mass flowmeter. Both streams were mixed in the channel of the reactor chip to form a slug flow. Light (375 nm) from an LED array (sum: 11.4 W) was used to irradiate the slug flow from a distance of 1 mm from the chip surface The product was collected in a vial tube and analyzed by ¹H NMR spectroscopy.