Key words
fluorination - organo-fluorine - selectivity - improved physical properties - isotopic
labelling - materials science
The presence of fluorine in organic molecules can improve or enhance the desirable
characteristic properties of materials that serve society.[1] For example, the application of polyfluorinated organic compounds ranges from important
monomeric gases such as anaesthetics and refrigerants to ‘non-stick’ polymeric solid
substances such as Teflon (Figure [1]). Whereas judicious choice of where to fluorinate more complex organic molecules
can enhance the desirable properties of healthcare and agricultural products,[2] it has been found that the subtle, strategic and site-selective introduction of
fluorine into biologically active organic compounds can lead to both dramatic and
fine tuning changes in properties. Here, fluorine can affect pK
a values and therefore binding affinities, pharmacokinetics and the bioavailability
of substances.[3] Selective and appropriate fluorination can also increase the half-life and dosing
rates of biologically active molecules by reducing the potential for metabolism through
oxidation of C–H bonds. Clearly, this leads to patients or crops being dosed less
frequently and in smaller quantities.
Radiolabelled compounds bearing ‘hot’ fluorine or 18F, such as [18F]-FDG (2-fluorodeoxyglucose) and [18F]-fluoro-l-dopa enable positron emission tomography (PET) scanning and are critical to the early
diagnosis of the onset of Alzheimer’s or Parkinson’s disease.[4] Alternatively, non-radiolabelled, ‘cold’ fluorine or 19F compounds can be used for medical diagnostics through 19F-magnetic resonance imaging (MRI).[5] Importantly for synthesis, fluorine can be used as a control element in asymmetric
reactions, where strategic placement provides a desirable gauche effect, leading to the enhancement of conformational rigidity of stereo-defining
transition states, resulting in improvements in enantioselectivity.[6] This particular effect has been explored in detail in the context of amine-based
organocatalysis. Furthermore, by appropriate fluorination of phenyl groups, fluorine
can be used to enhance noncovalent, π–π stacking interactions in asymmetric processes
mediated by organocatalytic BINOL-derived phosphoric acids.[7]
Duncan Brownestudied Chemistry with Study in Industry, at the University of Sheffield (with a placement
at GSK) graduating in 2006. He obtained his PhD in 2009 from the same institution
under the guidance of Prof. Joe Harrity and in collaboration with Syngenta. Following
a one year EPSRC Doctoral Prize Fellowship, in 2010 he joined Prof Steve Ley FRS CBE
at the University of Cambridge. In 2012, he was appointed as a college teaching associate
at Sidney Sussex College prior to joining the college fellowship and becoming director
of studies. In 2014, Duncan was appointed as a Lecturer in Organic Chemistry at Cardiff
University. His current research interests include the development of methods to access
under-represented organo-fluorine motifs, the development of continuous flow processing
techniques, and the exploration of mechano-chemical methods for synthetic chemistry.
Figure 1 Examples of functional organo-fluorine compounds
This brief survey, covering just a few of the known effects that fluorine can impart
to organic structures, demonstrates the power and importance of this combination.
Undoubtedly, these effects are ultimately attributable to the large electronegativity
of fluorine. However, a dichotomy exists whereby the extreme nature of this electronegativity
leads to a very high reactivity of its elemental form, a trait that is not appropriate
for the selective decoration of designed organic architectures. This high reactivity
poses many safety issues and consequently limits the use of F2 gas to reactions conducted in specialised equipment by suitably trained personnel.
Clearly such a restriction is not congruent with the research and discovery of molecules,
where convenience of use and generality of a process are generally sought. In this
context, since early observations of the synergy, the focus has been shifting towards
methods that are straightforward to execute and pose a minimal, or greatly reduced
safety hazard, whilst delivering absolute control and selectivity over the transformation.
This is largely being achieved in two distinct ways: (1) by starting with appropriately
fluorinated functionalized buildings blocks and using these to build up complexity,
or (2) by the late-stage introduction of fluorine or fluorinated motifs directly on
to the molecule of interest.
The discovery and furtherance of late-stage fluorination approaches has been greatly
facilitated by the development of new fluorinating agents that are inherently safer
and easier to manipulate than the likes of fluorine gas, hydrofluoric acid, sulfur
tetrafluoride or hyperfluorous acid. Some notable examples of these reagents are shown
in Figure [2], together with the year in which they were reported.[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
Figure 2 Examples of designed fluorinating agents for the selective and controlled fluorination
of organic molecules
Whilst it is true that some fluorinating agents begin to look exotic and expensive,
they merely serve a purpose for the discovery of new molecules, often this is done
with a late-stage ‘fluorine scan’. Not every fluorination is going to give a ‘better’
molecule; in fact, it is quite the opposite, which is perhaps part of the excitement!
Once the appropriate fluorination has been identified and the molecule is ready for
development then one can revert back to the robust methods to create the appropriate
building block for manufacture. Indeed, much of this chemistry can be out-sourced
to companies that specialise in the large-scale manufacture of fluorinated building
blocks employing such hazardous fluorinating materials.
In conclusion, the ability to selectively fluorinate organic molecules is of paramount
importance to the discovery of new molecules that possess superior performance compared
with their non-fluorinated counterparts. As such, organo-fluorine chemistry is becoming
a centre-piece for new reaction discovery and method development. These are exciting
times for organic chemistry in general. We are seeing the development and use of new
reaction manifolds such as photo-redox chemistry,[20] innate C–H activation,[19]
[21] multiple-bond-forming cascades,[22] photo-flow chemistry[23] and the use of computational methods to rationally design bespoke ligands.[24] It is a great pleasure to bring together some of the recent advances in this important
field from across the globe for this Cluster.
