Zolimidine Analogues: The Synthesis of Imidazo[1,2-α]pyridine-Based Sulfilimines and Sulfoximines

Abstract

Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N-acetylsulfilimine and -sulfoximine­ analogues under mild conditions. Deprotection of the N-acetylsulfoximine allows the preparation of the corresponding NH-sulfoximine.

Key words

imidazo[1,2-α]pyridine - sulfoximine - sulfilimine - zolimidine - imination

• References


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