Recent Advances in the Synthesis of 2-Substituted Oxetanes

Owen A. Davis; James A. Bull

doi:10.1055/s-0034-1380412

Synlett, Inhaltsverzeichnis

Synlett 2015; 26(10): 1283-1288
DOI: 10.1055/s-0034-1380412

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Recent Advances in the Synthesis of 2-Substituted Oxetanes

Owen A. Davis

Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK eMail: j.bull@imperial.ac.uk

,

James A. Bull*

Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK eMail: j.bull@imperial.ac.uk

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Abstract

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Abstract

Recent interest in oxetanes in medicinal chemistry and as synthetic intermediates has led to the development of a number of methods for the synthesis of more functionalized and highly substituted oxetane derivatives. Here we review cyclization approaches for the preparation of 2-substituted oxetanes. Methods involving C–O bond formation, as well as recently developed C–C bond forming cyclization strategies are highlighted.

Key words

Oxetanes - Heterocycles - Cyclization - Ethers - Insertion

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Referenzen

References

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