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Synthesis 2015; 47(13): 1905-1912
DOI: 10.1055/s-0034-1380516
DOI: 10.1055/s-0034-1380516
paper
Microwave-Assisted Synthesis of Fused and Substituted 2-Aminopyridines from β-Halo α,β-Unsaturated Aldehydes
Further Information
Publication History
Received: 27 November 2014
Accepted after revision: 09 March 2015
Publication Date:
21 April 2015 (online)
Abstract
2-Aminopyridines were synthesized from β-halo α,β-unsaturated aldehydes by a microwave-assisted Knoevenagel reaction. The β-halo-α,β-unsaturated aldehydes were, in turn, efficiently synthesized from the corresponding ketones by a Vilsmeier formylation reaction. The protocol was used to synthesize several novel steroidal and nonsteroidal fused 2-aminopyridine derivatives.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380516.
- Supporting Information
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