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Synthesis 2015; 47(18): 2776-2780
DOI: 10.1055/s-0034-1380720
DOI: 10.1055/s-0034-1380720
special topic
Synthesis of Heteroaryl-Substituted Pyrroles via the 1,3-Dipolar Cycloaddition of Unsymmetrical Münchnones and Nitrovinylheterocycles
Further Information
Publication History
Received: 12 March 2015
Accepted after revision: 16 April 2015
Publication Date:
19 May 2015 (online)
Abstract
A series of furanyl-, thiophenyl-, and pyrrolo-substituted pyrroles were prepared via the 1,3-dipolar cycloaddition of unsymmetrical münchnones and nitrovinylheterocycles. The regiochemical outcome of the furan and thiophene cycloadditions compares favorably to previously reported cycloadditions with β-nitrostyrene, while the nitrovinylpyrrole cycloadditions mirror the results observed with nitrovinylindole.
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