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Planta Med 2014; 80(12): 978-983
DOI: 10.1055/s-0034-1382901
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Effects of Dehydroeffusol on Spasmogen-Induced Contractile Responses of Rat Intestinal Smooth Muscles

Fan Di
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Haifeng Zhai
2   National Institute on Drug Dependence, Peking University, Beijing, China
,
Peng Li
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
,
Jianmei Huang
1   School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
› Author Affiliations
Further Information

Publication History

received 13 January 2014
revised 05 May 2014

accepted 23 June 2014

Publication Date:
04 August 2014 (online)

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Abstract

Dehydroeffusol is a naturally occurring phenanthrene isolated from Juncus effusus. In the context of screening new drugs against gastrointestinal spasms, we investigated its effects on isolated rat jejunum in vitro. Dehydroeffusol (30–90 µM) slightly and transiently enhanced contractions in a concentration-dependent manner but significantly inhibited the contractions induced by KCl (100 mM), (±)-Bay-K8644 (5 µM), pilocarpine (90 µM), and histamine (100 µM). These results show that dehydroeffusol may antagonize the spasmogenic activity of various agents, and therefore, could be a promising agent in the treatment of spasms. Its potential spasmolytic mechanism is also discussed.

Key words

dehydroeffusol - rat jejunum - spasmolytic - smooth muscle - Juncus effusus - Juncuaceae
 

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