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Planta Med 2014; 80(12): 974-977
DOI: 10.1055/s-0034-1382902
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Effect of Quercetin-3-O-Sambubioside Isolated from Eucommia ulmoides Male Flowers on Spontaneous Activity and Convulsion Rate in Mice

Xin Li
1   College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
,
Lipeng Yang
1   College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
,
Shaoyang Liu
2   Food Engineering Department, Luohe Medical College, Luohe, China
,
Dongqing Fei
3   School of Pharmacy, Lanzhou University, Lanzhou, China
,
Min Zhang
1   College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
,
Yuxian Zhang
1   College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China
› Author Affiliations
Further Information

Publication History

received 22 December 2013
revised 19 June 2014

accepted 20 June 2014

Publication Date:
06 August 2014 (online)

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Abstract

The purpose of this study was to evaluate the effects of quercetin-3-O-sambubioside on the neural system. Quercetin-3-O-sambubioside is a monomeric compound found in Eucommia ulmoides male flowers from which it was extracted using a system solvent method. In the experiments, spontaneous activity and convulsion rate in mice were recorded, and quercetin-3-O-sambubioside shows eminent effects similar to nikethamide on increasing spontaneous activity and stimulating the nerve center to enhance excitement. These findings are indicative of the powerful ability of quercetin-3-O-sambubioside to promote the stimulation of the nerve center.

Key words

Eucommia ulmoides - Eucommiaceae - quercetin-3-O-sambubioside - neural excitation - excitement

Supporting Information

 

  • References

  • 1 Yao XH, Deng JY, Huang HW. Genetic diversity in Eucommia ulmoides (Eucommiaceae), an endangered traditional Chinese medicinal plant. Conserv Genet 2012; 13: 1499-1507
    CrossrefPubMedSearch in Google Scholar
  • 2 Liu HL, Tang ML, An LY. Study on the optimum extraction technology of Eucommia ulmoides oliv. Nat Prod Res Dev 2001; 14: 47-50
    PubMedSearch in Google Scholar
  • 3 Xu SH, Zhao DG. [Inhibition of Eucommia bark protein against molds]. Food Sci Tech 2008; 3: 149-151 [in Chinese]
    PubMedSearch in Google Scholar
  • 4 Jiang CY, Xu JY, Bian YH, Shen JD, Xu Y. [The combination of regulation blood pressure component in Eucommia and vasodilator effects]. Chin J Exp Tradit Med Formulae 2010; 6: 218-220 [in Chinese]
    PubMedSearch in Google Scholar
  • 5 Li JM, Xu YM, Zhu KY, Chen QY, Zhang N, Li YJ. [Research progress on Eucommia antioxidation biological activity]. J Chin Med Pharmacol 2010; 2: 137-139 [in Chinese]
    PubMedSearch in Google Scholar
  • 6 Cheng GL. [Study of the active component and pharmacology mechanism of Eucommia]. Chin Tradit Pat Med 2006; 28: 723-725 [in Chinese]
    PubMedSearch in Google Scholar
  • 7 Geng JZ, Xu FX. [Progress in research on physiological functions and extraction and separation of alkaloids]. Surv Rev 2007; 10: 1-4 [in Chinese]
    PubMedSearch in Google Scholar
  • 8 Li X, Zhu WX, Fan JL, Xiao HF, Du L, Ma HL, Liu SY. [Study on the sedative and hypnotic effects of ethyl acetate extracts of Eucommia male flowers]. Academic Periodical Farm Prod Proc 2009; 8: 8-10 [in Chinese]
    PubMedSearch in Google Scholar
  • 9 Li X, Fan JL, Zhu WX, Ma HL, Liu SY. [Study on the sedative and hypnotic effects of n-butyl alcohol extracts of Eucommia male flowers]. Food Machinery 2009; 4: 56-58 [in Chinese]
    PubMedSearch in Google Scholar
  • 10 Liu SY, Li X, Zhu WX, Fan JL, Xiao HF, Du L. [Study on the sedative and hypnotic effects of water extracts of Eucommia male flowers]. Academic Periodical Farm Prod Proc 2010; 4: 29-31 [in Chinese]
    PubMedSearch in Google Scholar
  • 11 Lian XM, Zhu WX, Bai XT. [Determination of active ingredients and pharmacologic study on hypnotic effect of Eucommia staminate flowers tea]. Food Sci Tech 2007; 3: 203-205 [in Chinese]
    PubMedSearch in Google Scholar
  • 12 Li X, Zhu WX, Yang LP, Fei DQ, Fan JL, Du L, Liu Y. Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia . Nat Prod Res 2013; 27: 1657-1659
    CrossrefPubMedSearch in Google Scholar
  • 13 Liu ZL, Hui JZ, Peng YJ. [Extraction of active ingredients in Eucommia leaf]. Food Sci 2003; 24: 62-64 [in Chinese]
    PubMedSearch in Google Scholar
  • 14 Zhang Q, Su YQ, Zhang JF. Seasonal difference in antioxidant capacity and active compounds contents of Eucommia ulmoides Oliver leaf. Molecules 2013; 18: 1857-1868
    CrossrefPubMedSearch in Google Scholar
  • 15 Huang MY, Fu TYC, Shih PH, Lee CP, Yen GC. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats. Food Chem Toxicol 2006; 44: 1424-1431
    CrossrefPubMedSearch in Google Scholar
  • 16 Zhang WP, Fujikawa T, Mizuno K, Ooi K, Hirata T, Wada A. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats. Am J Chin Med 2012; 40: 735-752
    CrossrefPubMedSearch in Google Scholar
  • 17 Liu XY, Wang Y, Li YL. [Mechanism investigation of sedative and hypnotic actions for ursolicacid and quercitrin influences on levels of NO, LI-1β and TNF-α]. Chinese J Exp Tradit Med Formulae 2010; 9: 162-165 [in Chinese]
    PubMedSearch in Google Scholar
  • 18 Dai XP, Huang Q, Zhou BT, Gong ZC, Liu ZQ, Shi SY. Preparative isolation and purification of seven main antioxidants from Eucommia ulmoides Oliv. (Du-zhong) leaves using HSCCC guided DPPH-HPLC experiment. Food Chem 2013; 139: 536-570
    PubMedSearch in Google Scholar
  • 19 Webby RF. A flavonol triglycoside from Actinidia argurta var. giraldii . Phytochem 1991; 30: 2443-2444
    CrossrefPubMedSearch in Google Scholar
  • 20 Tang YP, Wang Y, Lou FC, Li YF, Wang JH. [Flavonol glycosides from the leaves of Ginkgo biloba]. Acta Pharm Sin 2000; 35: 363-366 [in Chinese]
    PubMedSearch in Google Scholar
  • 21 Yang ZF, Wang WN, Yang K, Wu II, Yang XB, Hang ZM. [Optimization of extraction technology for total flavones from leaves Apocynum venetum by orthogonal test]. Chinese Tradit Herbal Drugs 2006; 37: 1177-1178 [in Chinese]
    PubMedSearch in Google Scholar
  • 22 Jia ZJ, Zhu GJ, Wang JH. [Flavonoid constituents of the seeds of Nitraria Tangutorum Bolor]. J Lanzhou Univ (Nat Sci) 1991; 27: 102-107 [in Chinese]
    PubMedSearch in Google Scholar
  • 23 Frank GB, Jhamandas K. Effects of general stimulant drugs on the electrical responses of isolated slabs of catʼs cerebral cortex. Br J Pharmacol 1970; 39: 716-723
    CrossrefPubMedSearch in Google Scholar
  • 24 Watzman N, Barry 3rd H, Kinnard jr. WJ, Buckley JP. Comparison of different photobeam arrangements for measuring spontaneous activity of mice. J Pharm Sci 1966; 55: 907-909
    CrossrefPubMedSearch in Google Scholar