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DOI: 10.1055/s-0034-1384912
Nationale VersorgungsLeitlinie Therapie des Typ-2-Diabetes (Teil 2)[1]
Langfassung, Version 3, August 2013, AWMF-Registernr.: nvl-001gNational Disease Management Guideline Therapy of Type 2 Diabetes (Part 2)Long Version, Version 3, August 2013, AWMF register no.: nvl-001gPublication History
Publication Date:
01 September 2014 (online)
Inhaltsverzeichnis |
|
H 6 |
Pharmakotherapie |
H 6.1 |
Grundsätze der Wirkstoffauswahl bei der Pharmakotherapie von Menschen mit Typ-2-Diabetes |
H 6.2 |
Therapiealgorithmen |
H 6.2.1 |
Therapiealgorithmus der Deutschen Gesellschaft für Allgemein- und Familienmedizin (DEGAM) und der Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ) |
H 6.2.2 |
Therapiealgorithmus der Deutschen Diabetes Gesellschaft (DDG) und der Deutschen Gesellschaft für Innere Medizin (DGIM) |
H 6.3 |
Zusammenfassung der Studienlage zur Pharmakotherapie eines Typ-2-Diabetes mit oralen Antidiabetika und/oder Insulin |
H 6.4 |
Orale Antidiabetika und weitere parenterale Antidiabetika |
H 6.4.1 |
Metforminmonotherapie (Therapiestufe 2) |
H 6.4.2 |
Alternative Therapieoptionen bei Unverträglichkeit von Metformin bzw. und Kontraindikationen gegen Metformin |
H 6.4.3 |
Kombinationstherapie oraler Antidiabetika bzw. Insulintherapie (Therapiestufe 3) |
H 6.5 |
Insulintherapie |
H 6.5.1 |
Indikation für eine Insulintherapie |
H 6.5.2 |
Insulintherapie |
H 6.5.3 |
Konventionelle Insulintherapie (CT) |
H 6.5.4 |
Intensivierte konventionelle Insulintherapie (ICT) |
H 6.5.5 |
Spritz-Ess-Abstand |
H 6.5.6 |
Kombinationstherapie von Insulin und oralen (bzw. parenteralen) Antidiabetika |
H 6.6 |
Ausgewählte Kommentare zu einzelnen Therapeutika |
H 6.6.1 |
Orale Therapeutika mit gesicherter, günstiger Beeinflussung klinischer Endpunkte |
H 6.6.2 |
Insuline |
H 6.6.3 |
Medikamente ohne gesicherte günstige Beeinflussung klinischer Endpunkte |
H 7 |
Besondere Situationen |
H 7.1 |
Hypoglykämie |
H 7.1.1 |
Symptomatologie |
H 7.1.2 |
Ursachen für eine Hypoglykämie |
H 7.1.3 |
Behandlung von Hypoglykämien |
H 7.2 |
Perioperatives Management |
H 7.3 |
Diabetisches Koma |
H 7.4 |
Diabetes in der Arbeitswelt |
H 7.5 |
Diabetes und Kraftfahren |
H 7.6 |
Besonderheiten der Diabetestherapie im Alter/in der Altenpflege |
H 8 |
Versorgungskoordination und Nahtstellenmanagement |
H 8.1 |
Ambulante Versorgung |
H 8.1.1 |
Hausärzte |
H 8.1.2 |
Diabetologisch qualifizierte Ärzte und diabetologische Schwerpunktpraxen |
H 8.1.3 |
Versorgung zur Prävention und Behandlung von Folgeerkrankungen |
H 8.2 |
Stationäre Versorgung |
H 8.3 |
Rehabilitative Versorgung |
H 8.4 |
Strukturierte Behandlungsprogramme (DMP) |
H 9 |
Qualitätsmanagement und Qualitätsindikatoren |
H 9.1 |
Korrekte ärztliche Berufsausübung und Behandlungsgrundsätze |
H 9.2 |
Interne und externe Qualitätssicherung |
H 9.2.1 |
Qualitätsmanagementprogramme bei Diabetes mellitus |
H 9.2.2 |
Spezielle Qualitätssicherungsprogramme bei Diabetes mellitus |
H 9.2.3 |
Qualitätsindikatoren |
H 10 |
Kurzgefasste Diagnostik und Therapie diabetischer Folgeerkrankungen |
-
Bundesärztekammer (Arbeitsgemeinschaft der Deutschen Ärztekammern) (BÄK)
http://www.baek.de
-
Kassenärztliche Bundesvereinigung (KBV)
http://www.kbv.de
-
Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF)
http://www.awmf.org
sowie
-
Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ)
http://www.akdae.de
-
Deutsche Diabetes Gesellschaft (DDG)
http://www.deutsche-diabetes-gesellschaft.de
-
Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM)
http://www.degam.de
-
Deutsche Gesellschaft für Innere Medizin (DGIM) (vertreten durch die DDG)
http://www.dgim.de
-
Verband der Diabetesberatungs- und Schulungsberufe Deutschland (VDBD)
http://www.vdbd.de
Die Patientenbeteiligung wird durch die Kooperation mit dem Patientenforum gewährleistet.
Dieser Beitrag ist ein Nachdruck der NVL, deren Copyright das ÄZQ innehat. Ergänzungen und Modifikationen der Leitlinie sind über die Webseite http://www.diabetes.versorgungsleitlinien.de zugänglich.
1 Die genannten Autoren nahmen als offizielle Vertreter der jeweiligen Organisationen am Entstehungsprozess teil. Alle genannten Autoren sind Erstautoren; die Nennung erfolgte in alphabetischer Reihenfolge.
-
Literatur
- 1 Berger M, Grüsser M, Jörgens V et al. Behandlungs- und Schulungsprogramm für Typ-2-Diabetiker, die Insulin spritzen. Köln: Dt. Ärzte-Verl; 1989
- 2 Berger M, Grüsser M, Jörgens V et al. Behandlungs- und Schulungsprogramm für Typ-2-Diabetiker, die nicht Insulin spritzen. Köln: Dt. Ärzte-Verl; 1987
- 3 Anlauf-Wilhelm B, Fisch R, Gralki A et al. Den Füssen zu liebe (BARFUSS) – Strukturiertes Behandlungs- und Schulungsprogramm für Menschen mit Diabetes und einem diabetischen Fußsyndrom. 1999
- 4 Kulzer B, Hermanns N, Kubiak T et al. HyPOS – Unterzuckerungen besser wahrnehmen, vermeiden und bewältigen. Ein strukturiertes Schulungs- und Behandlungsprogramm für insulinpflichtige Diabetiker mit Hypoglykämieproblemen. Mainz: Kirchheim; 2006
- 5 Berger M, Grüsser M, Jörgens V. Behandlungs- und Schulungsprogramm für Typ-2-Diabetiker, die Normalinsulin spritzen. Köln: Dt. Ärzte-Verl; 1987
- 6 Kulzer B, Hermanns N, Maier B et al. MEDIAS 2 – mehr Diabetes Selbstmanagement für Typ 2. Ein Schulungs- und Behandlungsprogramm für Menschen mit nicht-insulinpflichtigem Typ-2-Diabetes. Mainz: Kirchheim; 2001
- 7 Brinkmeier U, Tewes A, Tegtbur U. Diabetes & Verhalten. Schulungsprogramm für Menschen mit Typ-2-Diabetes, die Insulin spritzen. Mainz: Kirchheim; 2009
- 8 Kulzer B, Hermanns N, Maier B et al. MEDIAS 2 – mehr Diabetes Selbstmanagement für Typ 2. Ein Schulungs- und Behandlungsprogramm für Menschen Typ-2-Diabetes und einer intensivierten Insulintherapie (ICT). Mainz: Kirchheim; 2011
- 9 Ärztliche Zentralstelle Qualitätssicherung (ÄZQ). Leitlinien-Clearingbericht "Diabetes mellitus Typ 2". München: Zuckschwerdt; 2001 (äzq Schriftenreihe; 8). Available from: http://www.leitlinien.de/leitlinienmethodik/clearingverfahren/aezq/clearingverfahren_99-05/clearingberichte/leitlinien-clearingverfahren-diabetes-mellitus%20
- 10 Colberg SR, Albright AL, Blissmer BJ et al. Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sports Exerc 2010; 42 (12) 2282-2303 http://www.ncbi.nlm.nih.gov/pubmed/21084931
- 11 Inzucchi SE, Bergenstal RM, Buse JB et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012; 35 (06) 1364-1379 http://www.ncbi.nlm.nih.gov/pubmed/22517736
- 12 Bantle JP, Wylie-Rosett J, Albright AL et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 2008; 31 (Suppl. 01) S61-S78 http://www.ncbi.nlm.nih.gov/pubmed/18165339
- 13 American Diabetes Association (ADA). Standards of medical care in diabetes – 2009. Diabetes Care 2009; 32 (Suppl. 01) S13-S61 http://www.ncbi.nlm.nih.gov/pubmed/19118286.
- 14 American Diabetes Associatio (ADA). Standards of medical care in diabetes – 2012. Diabetes Care 2012; 35 (Suppl. 01) S11-S63 http://www.ncbi.nlm.nih.gov/pubmed/22187469
- 15 Franz MJ, Powers MA, Leontos C et al. The evidence for medical nutrition therapy for type 1 and type 2 diabetes in adults. J Am Diet Assoc 2010; 110 (12) 1852-1889 http://www.ncbi.nlm.nih.gov/pubmed/21111095
- 16 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Empfehlungen zur antihyperglykämischen Therapie des Diabetes mellitus Typ 2. 2. Aufl.. 2009 [cited: 2013 Jul 02]. Available from: http://www.akdae.de/Arzneimitteltherapie/TE/A-Z/PDF/Diabetes2.pdf
- 17 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Typ-2-Diabetes-Präventions- und Behandlungsstrategien für Fußkomplikationen. 2006 [cited: 2013 Jul 01]. Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_fuss/index_html
- 18 Bundesärztekammer (BÄK), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), Kassenärztliche Bundesvereinigung (KBV). Nationale VersorgungsLeitlinie Typ-2-Diabetes-Prävention und Therapie von Netzhautkomplikationen. 2006 [cited: 2013 Apr 08]. Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_netzhaut/index_html
- 19 Bundesärztekammer (BÄK), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), Kassenärztliche Bundesvereinigung (KBV). Nationale VersorgungsLeitlinie Nierenerkrankungen bei Diabetes im Erwachsenenalter. Langfassung. 2010 [cited: 2013 Mae 05]. Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_nephro
- 20 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Chronische KHK. Langfassung. Köln: Dt. Ärzte-Verl; 2007 Available from: http://www.khk.versorgungsleitlinien.de
- 21 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Neuropathie bei Diabetes im Erwachsenenalter. 2011 [cited: 2013 Jul 01]. Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_neuro
- 22 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Diabetes. Strukturierte Schulungsprogramme – Langfassung. Version 1.0. 2012 [cited: 2013 Jan 02]. Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_schulung
- 23 Scherbaum WA, Haak T, Halle M et al. Körperliche Aktivität und Diabetes mellitus. Evidenzbasierte Leitlinie der Deutschen Diabetes-Gesellschaft. 2008 [cited: 2013 Jul 04]. Available from: http://www.awmf.org/uploads/tx_szleitlinien/057-022_S3_Koerperliche_Aktivitaet_und_Diabetes_mellitus_10-2008_10-2013.pdf
- 24 Matthaei S, Bierwirth R, Fritsche A et al. Medikamentöse antihyperglykämische Therapie des Diabetes mellitus Typ 2. Update der Evidenzbasierten Leitlinie der Deutschen Diabetes-Gesellschaft. Diabetologie 2009; 4: 32-64 http://www.deutsche-diabetes-gesellschaft.de/fileadmin/Redakteur/Leitlinien/Evidenzbasierte_Leitlinien/EBL_Dm_Typ2_Update_2008.pdf
- 25 Zeyfang A, Bahrmann A, Wernecke J. Diabetes mellitus im Alter. Diabetologie 2012; 7 (Suppl. 02) S163-S169
- 26 Kemmer FW, Halle M, Stumvoll M et al. Diabetes, Sport und Bewegung. Praxisleitlinie der Deutschen Diabetes-Gesellschaft. Diabet Stoffw 2009; 4 (Suppl. 02) S113-S200 https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0029-1224571
- 27 Kulzer B, Albus C, Herpertz S et al. Psychosoziales und Diabetes mellitus. Diabet Stoffw 2012; 7 S02: S136-S142 https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0032-1325580
- 28 Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN), Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression. 2009 [cited: 2013 Jul 01]. Available from: http://www.versorgungsleitlinien.de/themen/depression
- 29 Leitliniengruppe Hessen. Diabetes mellitus Typ 2. Therapie des Diabetes mellitus Typ 2. Hausärztliche Leitlinie. 2007 [cited: 2013 Jul 02]. Available from: http://www.pmvforschungsgruppe.de/pdf/03_publikationen/diabetes_ll.pdf
- 30 National Institute for Health and Clinical Excellence (NICE). Type 2 diabetes: the management of type 2 diabetes (update). 2008 [cited: 2013 Jul 01]. Available from: http://guidance.nice.org.uk/CG66
- 31 Scottish Intercollegiate Guidelines Network (SIGN). Management of diabetes. A national clinical guideline. Edinburgh: SIGN; 2010 (SIGN Publications; 116). Available from: http://www.sign.ac.uk/pdf/sign116.pdf
- 32 Toeller M. Ernährungsempfehlungen bei Diabetes und deren Implementierung. Update anhand ausgewählter Publikationen. Diabetologe 2009; 5 (06) 442-452 http://link.springer.com/article/10.1007/s11428-009-0405-1.
- 33 Toeller M. Evidenz-basierte Ernährungsempfehlungen zur Behandlung und Prävention des Diabetes mellitus. Autorisierte deutsche Version nach: Diabetes and Nutrition Study Group (DNSG). (Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis 14(2004) 373–394 Diabet Stoffw 2005; 14: 75-94 http://www.deutsche-diabetes-gesellschaft.de/fileadmin/Redakteur/Leitlinien/Evidenzbasierte_Leitlinien/EBL_Ernaehrung_2005.pdf
- 34 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationales Programm für VersorgungsLeitlinien. Methoden-Report. 4 Aufl. 2010 [cited: 2013 Mae 05]. Available from: http://www.versorgungsleitlinien.de/methodik/pdf/nvl_methode_4.aufl.pdf
- 35 Europarat, Verbindung der Schweizer Ärztinnen und Ärzte, Ärztliche Zentralstelle Qualitätssicherung, Ludwig Boltzmann Institut für Krankenhausorganisation. Entwicklung einer Methodik für die Ausarbeitung von Leitlinien für optimale medizinische Praxis. Empfehlung Rec (2001)13 des Europarates am 10. Oktober 2001 und Erläuterndes Memorandum. Deutschsprachige Ausgabe. Z Arztl Fortbild Qualitatssich 2002; 96 (Suppl. 03) 3-60 http://www.leitlinien.de/mdb/edocs/pdf/literatur/europaratmethdt.pdf
- 36 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV). Beurteilungskriterien für Leitlinien in der medizinischen Versorgung – Beschlüsse der Vorstände der Bundesärztekammer und Kassenärztlicher Bundesvereinigung, Juni 1997. Dtsch Arztebl 1997; 94 (33) A 2154-A 2155 http://www.aerzteblatt.de/pdf/94/33/a2154-5.pdf
- 37 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Erarbeitung von Leitlinien für Diagnostik und Therapie. Methodische Empfehlungen ("Leitlinie für Leitlinien", Stand Dezember 2004). 2004 [cited: 2012 Mai 31]. Available from: http://www.awmf.org/fileadmin/user_upload/Leitlinien/Werkzeuge/Publikationen/methoden.pdf
- 38 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV). Das Leitlinien-Clearingverfahren von Bundesärztekammer und Kassenärztlicher Bundesvereinigung in Zusammenarbeit mit der Deutschen Krankenhausgesellschaft und den Spitzenverbänden der Gesetzlichen Krankenversicherungen, Ziele und Arbeitsplan. Dtsch Arztebl 1999; 96 (33) A2105-A2106 http://www.aerzteblatt.de/v4/archiv/pdf.asp?id=18624
- 39 Ärztliches Zentrum für Qualität in der Medizin (ÄZQ), Ärztliche Zentralstelle Qualitätssicherung (ÄZQ). Leitlinien-Clearingberichte, 1999–2005. 2005 [cited: 2013 Mae 05]. Available from: http://www.leitlinien.de/leitlinienmethodik/clearingverfahren/aezq/clearingverfahren_99-05
- 40 Ärztliches Zentrum für Qualität in der Medizin (ÄZQ), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Deutsches Instrument zur methodischen Leitlinien-Bewertung (DELBI). Fassung 2005/2006. Z Arztl Fortbild Qualitatssich 2005; 99 (08) 468-519
- 41 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Das AWMF-Regelwerk Leitlinien. 2012 Available from: http://www.awmf.org/leitlinien/awmf-regelwerk.html
- 42 Ollenschläger G, Marshall C, Qureshi S et al. Improving the quality of health care: using international collaboration to inform guideline programmes by founding the Guidelines International Network (G-I-N). Qual Saf Health Care 2004; 13 (06) 455-460 http://www.ncbi.nlm.nih.gov/pubmed/15576708
- 43 New Zealand Guidelines Group (NZGG). Handbook for the preparation of explicit evidence-based clinical practice guidelines. Wellington: NZGG; 2001
- 44 Leitliniengruppe Hessen. Leitlinienreport-Allgemeiner Leitlinienreport. Version 3.00, Stand Januar 2009. 2009 [cited: 2012 Mai 31]. Available from: http://www.pmvforschungsgruppe.de/pdf/03_publikationen/allgemein_report.pdf
- 45 Ollenschläger G, Thomeczek C, Thalau F et al. Medizinische Leitlinien in Deutschland, 1994 bis 2004. Von der Leitlinienmethodik zur Leitlinienimplementierung. Z Arztl Fortbild Qualitatssich 2005; 99 (01) 7-13 http://www.ncbi.nlm.nih.gov/pubmed/15804124
- 46 Schneider M, Lelgemann M. Methodenreport zur Entwicklung der Leitlinie „Management der frühen rheumatoiden Arthritis“. Anlage 1 zu „Management der frühen rheumatoiden Arthritis. Interdisziplinäre Leitlinie“. Berlin: DGRh; 2004
- 47 Fervers B, Remy-Stockinger M, Graham ID et al. Guideline adaptation: an appealing alternative to de novo guideline development. Ann Intern Med 2008; 148 (07) 563-564 http://www.ncbi.nlm.nih.gov/pubmed/18378955
- 48 Fervers B, Burgers JS, Haugh MC et al. Adaptation of clinical guidelines: literature review and proposition for a framework and procedure. Int J Qual Health Care 2006; 18 (03) 167-176 http://www.ncbi.nlm.nih.gov/pubmed/16766601
- 49 Atkins D, Best D, Briss PA et al. Grading quality of evidence and strength of recommendations. BMJ 2004; 328 (7454) 1490-1497 http://www.ncbi.nlm.nih.gov/pubmed/15205295
- 50 Guyatt GH, Oxman AD, Vist GE et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336 (7650) 924-926 http://www.ncbi.nlm.nih.gov/pubmed/18436948
- 51 Dunham RB. Nominal Group Technique: A Users' guide. Madison: Wisconsin School of Business; 1998
- 52 Murphy MK, Black NA, Lamping DL et al. Consensus development methods, and their use in clinical guideline development. Health Technol Assess 1998; 2 (03) i-88 http://www.ncbi.nlm.nih.gov/pubmed/9561895
- 53 Stinner B, Bauhofer A, Sitter H et al. Nominaler Gruppenprozess als Konsensusinstrument zur Einschränkung der Therapieheterogenität in einer komplexen "outcome"-Studie. Intensivmed Notfallmed 2000; 37 (Suppl. 02) 30
- 54 Bundesärztekammer (BÄK), Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ), Deutsche Diabetes Gesellschaft (DDG), Fachkommission Diabetes Sachsen (FDS), Deutsche Gesellschaft für Innere Medizin (DGIM), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale Versorgungs-Leitlinie Diabetes mellitus Typ 2. Köln: BÄK; 2002
- 55 Kahn SE, Haffner SM, Heise MA et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006; 355 (23) 2427-2443 http://www.ncbi.nlm.nih.gov/pubmed/17145742
- 56 U. K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U. K. Prospective Diabetes Study Group. Diabetes 1995; 44 (11) 1249-1258 http://www.ncbi.nlm.nih.gov/pubmed/7589820
- 57 Holman RR. Assessing the potential for alpha-glucosidase inhibitors in prediabetic states. Diabetes Res Clin Pract 1998; 40 Suppl: S21-S25 http://www.ncbi.nlm.nih.gov/pubmed/9740498
- 58 Zimmet P, Alberti KG MM, Serrano RiosM. A new international diabetes federation worldwide definition of the metabolic syndrome: the rationale and the results. Rev Esp Cardiol 2005; 58 (12) 1371-1376 http://www.ncbi.nlm.nih.gov/pubmed/16371194
- 59 Schulze MB, Hoffmann K, Boeing H et al. An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care 2007; 30 (03) 510-515 http://www.ncbi.nlm.nih.gov/pubmed/17327313
- 60 Kurth BM. Erste Ergebnisse aus der „Studie zur Gesundheit Erwachsener in Deutschland" (DEGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012; 55 (08) 980-990
- 61 Rathmann W, Scheidt-Nave C, Roden M et al. Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction. Dtsch Arztebl Int 2013; 110 (19) 331-337 http://www.ncbi.nlm.nih.gov/pubmed/23762204
- 62 Heidemann C, Du Y, Scheidt-Nave C. , Robert Koch Institut (RKI). Diabetes mellitus in Deutschland. 2011 [cited: 2013 Jul 04]. Available from: http://www.rki.de/DE/Content/Gesundheitsmonitoring/Gesundheitsberichterstattung/GBEDownloadsK/2011_3_diabetes.pdf?__blob=publicationFile
- 63 Nordrheinische Gemeinsame Einrichtung Disease-Management-Programme. Qualitätssicherungsbericht 2010. Disease-Management-Programme in Nordrhein. Brustkrebs, Diabetes mellitus Typ 1/Typ 2, Koronare Herzkrankheit, Asthma/COPD. Düsseldorf: Nordrheinische Gemeinsame Einrichtung DMP; 2011
- 64 Samann A, Tajiyeva O, Muller N et al. Prevalence of the diabetic foot syndrome at the primary care level in Germany: a cross-sectional study. Diabet Med 2008; 25 (05) 557-563 http://www.ncbi.nlm.nih.gov/pubmed/18346154
- 65 Blum M, Kloos C, Muller N et al. Prevalence of diabetic retinopathy. Check-up program of a public health insurance company in Germany 2002–2004. Ophthalmologe 2007; 104 (06) 499-504 http://www.ncbi.nlm.nih.gov/pubmed/17457588.
- 66 Nordrheinische Gemeinsame Einrichtung Disease-Management-Programme. Qualitätssicherungsbericht 2009. Disease-Management-Programme in Nordrhein. Brustkrebs, Diabetes mellitus Typ 1/Typ 2, Koronare Herzkrankheit, Asthma/COPD. Düsseldorf: Nordrheinische Gemeinsame Einrichtung DMP; 2010
- 67 Perna L, Thien-Seitz U, Ladwig KH et al. Socio-economic differences in life expectancy among persons with diabetes mellitus or myocardial infarction: results from the German MONICA/KORA study. BMC Public Health 2010; 10: 135 http://www.ncbi.nlm.nih.gov/pubmed/20233394.
- 68 Miksch A, Laux G, Ose D et al. Is there a survival benefit within a German primary care-based disease management program?. Am J Manag Care 2010; 16 (01) 49-54 http://www.ncbi.nlm.nih.gov/pubmed/20148605
- 69 American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33 (Suppl. 01) S62-S69 http://www.ncbi.nlm.nih.gov/pubmed/20042775.
- 70 World Health Organization (WHO), International Diabetes Federation (IDF). Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO/IDF Consultation 2006 [cited: 2013 Jul 04]. Available from: http://www.who.int/diabetes/publications/Definition%20and%20diagnosis%20of%20diabetes_new.pdf
- 71 American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29 (Suppl. 01) S43-S48 http://www.ncbi.nlm.nih.gov/pubmed/16373932
- 72 Hawa MI, Kolb H, Schloot N et al. Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7. Diabetes Care 2013; 36 (04) 908-913 http://www.ncbi.nlm.nih.gov/pubmed/23248199
- 73 Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444 (7121) 840-846 http://www.ncbi.nlm.nih.gov/pubmed/17167471
- 74 American Diabetes Association (ADA). Standards of medical care in diabetes – 2006. Diabetes Care 2006; 29 (Suppl. 01) S4-S42 http://www.ncbi.nlm.nih.gov/pubmed/16373931
- 75 New Zealand Guidelines Group (NZGG). Management of Type 2 Diabetes. 2003 [cited: 2013 Jul 04]. Available from: http://www.nzgg.org.nz/guidelines/dsp_guideline_popup.cfm?guidelineCatID=30&guidelineID=36
- 76 American Diabetes Association (ADA). Standards of medical care in diabetes – 2010. Diabetes Care 2010; 33 (Suppl. 01) S11-S61 http://www.ncbi.nlm.nih.gov/pubmed/20042772
- 77 Benjamin EM, Schneider MS, Hinchey KT. Implementing practice guidelines for diabetes care using problem-based learning. A prospective controlled trial using firm systems. Diabetes Care 1999; 22 (10) 1672-1678 http://www.ncbi.nlm.nih.gov/pubmed/10526733
- 78 Olivarius NF, Beck-Nielsen H, Andreasen AH et al. Randomised controlled trial of structured personal care of type 2 diabetes mellitus. BMJ 2001; 323 (7319) 970-975 http://www.ncbi.nlm.nih.gov/pubmed/11679387
- 79 Greenfield S, Kaplan SH, Ware Jr JE et al. Patients' participation in medical care: effects on blood sugar control and quality of life in diabetes. J Gen Intern Med 1988; 3 (05) 448-457 http://www.ncbi.nlm.nih.gov/pubmed/3049968
- 80 Pill R, Stott NC, Rollnick SR et al. A randomized controlled trial of an intervention designed to improve the care given in general practice to Type II diabetic patients: patient outcomes and professional ability to change behaviour. Fam Pract 1998; 15 (03) 229-235 http://www.ncbi.nlm.nih.gov/pubmed/9694180
- 81 Janka HU, Balletshofer B, Becker A. Das metabolische Syndrom als potenter Risikofaktor für frühzeitigen Tod bei Typ 2 Diabetikern. Die Schwabinger Studie II – Untersuchungen nach 9 Jahren. Diabet Stoffw 1992; 1: 2-7
- 82 Laakso M, Kuusisto J. Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. Ann Med 1996; 28 (05) 415-418 http://www.ncbi.nlm.nih.gov/pubmed/8949972
- 83 Uusitupa M, Siitonen O, Aro A et al. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 1985; 28 (01) 22-27 http://www.ncbi.nlm.nih.gov/pubmed/3979684
- 84 Bundesärztekammer (BÄK), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), Kassenärztliche Bundesvereinigung (KBV). Nationale Versorgungs Leitlinie KHK. 2006 [cited: 2012 Mär 30]. Available from: http://www.versorgungsleitlinien.de/themen/khk
- 85 Stratton IM, Adler AI, Neil HA et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321 (7258) 405-412 http://www.ncbi.nlm.nih.gov/pubmed/10938048
- 86 de Vegt F, Dekker JM, Ruhe HG et al. Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 1999; 42 (08) 926-931 http://www.ncbi.nlm.nih.gov/pubmed/10491751
- 87 Selvin E, Wattanakit K, Steffes MW et al. HbA1c and peripheral arterial disease in diabetes: the Atherosclerosis Risk in Communities study. Diabetes Care 2006; 29 (04) 877-882 http://www.ncbi.nlm.nih.gov/pubmed/16567831
- 88 Selvin E, Coresh J, Shahar E et al. Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Lancet Neurol 2005; 4 (12) 821-826 http://www.ncbi.nlm.nih.gov/pubmed/16297840
- 89 Selvin E, Coresh J, Golden SH et al. Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study. Arch Intern Med 2005; 165 (16) 1910-1916 http://www.ncbi.nlm.nih.gov/pubmed/16157837
- 90 Khaw KT, Wareham N, Bingham S et al. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med 2004; 141 (06) 413-420 http://www.ncbi.nlm.nih.gov/pubmed/15381514
- 91 Coutinho M, Gerstein HC, Wang Y et al. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care 1999; 22 (02) 233-40 http://www.ncbi.nlm.nih.gov/pubmed/10333939
- 92 Selvin E, Marinopoulos S, Berkenblit G et al. Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 2004; 141 (06) 421-431 http://www.ncbi.nlm.nih.gov/pubmed/15381515
- 93 American Acadamy of Family Physicians (AAFP). The benefits and risks of controlling blood glucose levels in patients with type 2 diabetes mellitus. 2005 [cited: 2013 Jul 04]. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.173.3576&rep=rep1&type=pdf
- 94 Patel A, MacMahon S, Chalmers J et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358 (24) 2560-2572 http://www.ncbi.nlm.nih.gov/pubmed/18539916
- 95 Ohkubo Y, Kishikawa H, Araki E et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995; 28 (02) 103-117 http://www.ncbi.nlm.nih.gov/pubmed/7587918
- 96 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352 (9131) 837-853 http://www.ncbi.nlm.nih.gov/pubmed/9742976
- 97 Lasker RD. The diabetes control and complications trial. Implications for policy and practice. N Engl J Med 1993; 329 (14) 1035-1036 http://www.ncbi.nlm.nih.gov/pubmed/8366905
- 98 UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352 (9131) 854-865 http://www.ncbi.nlm.nih.gov/pubmed/9742977
- 99 Gerstein HC, Miller ME, Byington RP et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358 (24) 2545-2559 http://www.ncbi.nlm.nih.gov/pubmed/18539917
- 100 The ORIGIN Trial Investigators. Basal Insulin and Cardiovascular and Other Outcomes in Dysglycemia. N Engl J Med 2012; http://www.ncbi.nlm.nih.gov/pubmed/22686416
- 101 Ray KK, Seshasai SR, Wijesuriya S et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 2009; 373 (9677) 1765-1772 http://www.ncbi.nlm.nih.gov/pubmed/19465231
- 102 Kelly TN, Bazzano LA, Fonseca VA et al. Systematic review: glucose control and cardiovascular disease in type 2 diabetes. Ann Intern Med 2009; 151 (06) 394-403 http://www.ncbi.nlm.nih.gov/pubmed/19620144
- 103 Richter B, Lerch C. Metabolische Kontrolle beim Typ 2 Diabetes mellitus – alles unter oder außer Kontrolle?. Z Allg Med 2010; 85 (01) 14-18
- 104 Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 2011; 343: d4169 http://www.ncbi.nlm.nih.gov/pubmed/21791495
- 105 Hemmingsen B, Lund SS, Gluud C et al. Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ 2011; 343: d6898 http://www.ncbi.nlm.nih.gov/pubmed/22115901
- 106 Hemmingsen B, Lund SS, Gluud C et al. Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev 2011; (06) CD008143 http://www.ncbi.nlm.nih.gov/pubmed/21678374
- 107 Turnbull FM, Abraira C, Anderson RJ et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 2009; 52 (11) 2288-2298 http://www.ncbi.nlm.nih.gov/pubmed/19655124
- 108 ACCORD Study Group. Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus (ACCORD). N Engl J Med 2010; http://www.ncbi.nlm.nih.gov/pubmed/20228404
- 109 Dluhy RG, McMahon GT. Intensive glycemic control in the ACCORD and ADVANCE trials. N Engl J Med 2008; 358 (24) 2630-2633 http://www.ncbi.nlm.nih.gov/pubmed/18539918
- 110 Gaede P, Vedel P, Larsen N et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003; 348 (05) 383-393 http://www.ncbi.nlm.nih.gov/pubmed/12556541
- 111 Wilson PW, D'Agostino RB, Parise H et al. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005; 112 (20) 3066-3072 http://www.ncbi.nlm.nih.gov/pubmed/16275870
- 112 Kahn R, Buse J, Ferrannini E et al. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005; 28 (09) 2289-2304 http://www.ncbi.nlm.nih.gov/pubmed/16123508
- 113 Nathan DM, Buse JB, Davidson MB et al. Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2006; 49 (08) 1711-1721 http://www.ncbi.nlm.nih.gov/pubmed/16802130
- 114 Qaseem A, Vijan S, Snow V et al. Glycemic control and type 2 diabetes mellitus: the optimal hemoglobin A1c targets. A guidance statement from the American College of Physicians. Ann Intern Med 2007; 147 (06) 417-22 http://www.ncbi.nlm.nih.gov/pubmed/17876024
- 115 Ryden L, Standl E, Bartnik M et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 2007; 28 (01) 88-136 http://www.ncbi.nlm.nih.gov/pubmed/17220161
- 116 American Diabetes Association (ADA). Standards of medical care in diabetes – 2007. Diabetes Care 2007; 30 (Suppl. 01) S4-S41 http://www.ncbi.nlm.nih.gov/pubmed/17192377
- 117 Canadian Diabetes Association. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Can J Diabetes 2008; 32 (Suppl. 01) 1-201
- 118 Psaty BM, Prentice RL. Variation in event rates in trials of patients with type 2 diabetes. JAMA 2009; 302 (15) 1698-1700 http://www.ncbi.nlm.nih.gov/pubmed/19843906
- 119 Currie CJ, Peters JR, Tynan A et al. Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study. Lancet 2010; 375 (9713) 481-489 http://www.ncbi.nlm.nih.gov/pubmed/20110121
- 120 Duckworth W, Abraira C, Moritz T et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009; 360 (02) 129-139 http://www.ncbi.nlm.nih.gov/pubmed/19092145
- 121 Donahue RP, Abbott RD, Reed DM et al. Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry. Honolulu Heart Program. Diabetes 1987; 36 (06) 689-692 http://www.ncbi.nlm.nih.gov/pubmed/3569669
- 122 Landgraf R. Approaches to the management of postprandial hyperglycaemia. Exp Clin Endocrinol Diabetes 1999; 107 (Suppl. 04) S128-S132 http://www.ncbi.nlm.nih.gov/pubmed/10522837
- 123 Shaw JE, Hodge AM, de Courten M et al. Isolated post-challenge hyperglycaemia confirmed as a risk factor for mortality. Diabetologia 1999; 42 (09) 1050-1054 http://www.ncbi.nlm.nih.gov/pubmed/10447514
- 124 Gerstein HC. Glucose: a continuous risk factor for cardiovascular disease. Diabet Med 1997; 14 (Suppl. 03) S25-S31 http://www.ncbi.nlm.nih.gov/pubmed/9272610
- 125 Hanefeld M, Temelkova-Kurktschiev T. The postprandial state and the risk of atherosclerosis. Diabet Med 1997; 14 (Suppl. 03) S6-S11 http://www.ncbi.nlm.nih.gov/pubmed/9272607
- 126 Pyorala K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 1979; 2 (02) 131-141 http://www.ncbi.nlm.nih.gov/pubmed/520116
- 127 Haller H. Postprandial glucose and vascular disease. Diabet Med 1997; 14 (Suppl. 03) S50-S56 http://www.ncbi.nlm.nih.gov/pubmed/9272614
- 128 Tominaga M, Eguchi H, Manaka H et al. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 1999; 22 (06) 920-924 http://www.ncbi.nlm.nih.gov/pubmed/10372242
- 129 Leiter LA, Ceriello A, Davidson JA et al. Postprandial glucose regulation: new data and new implications. Clin Ther 2005; 27 (Suppl B) S42-S56 http://www.ncbi.nlm.nih.gov/pubmed/16519037
- 130 Home P. Contributions of basal and post-prandial hyperglycaemia to micro- and macrovascular complications in people with type 2 diabetes. Curr Med Res Opin 2005; 21 (07) 989-998 http://www.ncbi.nlm.nih.gov/pubmed/16004665
- 131 Gerich JE. Postprandial hyperglycemia and cardiovascular disease. Endocr Pract 2006; 12 (Suppl. 01) 47-51 http://www.ncbi.nlm.nih.gov/pubmed/16627380
- 132 Ceriello A. The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications. Diabet Med 1998; 15 (03) 188-193 http://www.ncbi.nlm.nih.gov/pubmed/9545118
- 133 Ceriello A. Postprandial hyperglycemia and diabetes complications: is it time to treat?. Diabetes 2005; 54 (01) 1-7 http://www.ncbi.nlm.nih.gov/pubmed/15616004
- 134 Raz I, Wilson PW, Strojek K et al. Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trial. Diabetes Care 2009; 32 (03) 381-386 http://www.ncbi.nlm.nih.gov/pubmed/19246588
- 135 American Diabetes Association (ADA). Postprandial blood glucose. American Diabetes Association. Diabetes Care 2001; 24 (04) 775-778 http://www.ncbi.nlm.nih.gov/pubmed/11315848
- 136 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Empfehlungen zur Therapie von Tabakabhängigkeit. Köln: AkdÄ; 2001 (Arzneiverordnung in der Praxis; 2001). Available from: http://www.akdae.de/Arzneimitteltherapie/TE/Archiv/Tabakabhaengigkeit.pdf
- 137 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Empfehlungen zur Prophylaxe und Therapie der stabilen koronaren Herzkrankheit. Köln: AkdÄ; 2004 (Arzneiverordnung in der Praxis; 31). Available from: http://www.akdae.de/Arzneimitteltherapie/TE/A-Z/PDF/KHK.pdf#page=1&view=fitB
- 138 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Empfehlungen zur Therapie der arteriellen Hypertonie. 2nd ed. Köln: AkdÄ; 2004 (Arzneiverordnung in der Praxis; 31). Available from: http://www.akdae.de/Arzneimitteltherapie/TE/Archiv/Hypertonie.pdf
- 139 Adler AI, Stratton IM, Neil HA et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ 2000; 321 (7258) 412-419 http://www.ncbi.nlm.nih.gov/pubmed/10938049
- 140 Turner RC, Millns H, Neil HA et al. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 1998; 316 (7134) 823-828 http://www.ncbi.nlm.nih.gov/pubmed/9549452
- 141 UK Prospective Diabetes Study (UKPDS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998; 317 (7160) 703-713 http://www.ncbi.nlm.nih.gov/pubmed/9732337
- 142 Klein R, Klein BE, Moss SE et al. Is blood pressure a predictor of the incidence or progression of diabetic retinopathy?. Arch Intern Med 1989; 149 (11) 2427-2432 http://www.ncbi.nlm.nih.gov/pubmed/2684072
- 143 ACCORD Study Group. Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus. N Engl J Med 2010; 362 (17) 1575-1585 http://www.ncbi.nlm.nih.gov/pubmed/20228401
- 144 Biesenbach G, Grafinger P, Janko O et al. Influence of cigarette-smoking on the progression of clinical diabetic nephropathy in type 2 diabetic patients. Clin Nephrol 1997; 48 (03) 146-150 http://www.ncbi.nlm.nih.gov/pubmed/9342485
- 145 Chase HP, Garg SK, Marshall G et al. Cigarette smoking increases the risk of albuminuria among subjects with type I diabetes. JAMA 1991; 265 (05) 614-617 http://www.ncbi.nlm.nih.gov/pubmed/1987411
- 146 Forsblom CM, Groop PH, Ekstrand A et al. Predictors of progression from normoalbuminuria to microalbuminuria in NIDDM. Diabetes Care 1998; 21 (11) 1932-1938 http://www.ncbi.nlm.nih.gov/pubmed/9802746
- 147 Muhlhauser I, Bender R, Bott U et al. Cigarette smoking and progression of retinopathy and nephropathy in type 1 diabetes. Diabet Med 1996; 13 (06) 536-543 http://www.ncbi.nlm.nih.gov/pubmed/8799657
- 148 Faronato PP, Maioli M, Tonolo G et al. Clustering of albumin excretion rate abnormalities in Caucasian patients with NIDDM. The Italian NIDDM Nephropathy Study Group. Diabetologia 1997; 40 (07) 816-823 http://www.ncbi.nlm.nih.gov/pubmed/9243103
- 149 Roglic G, Colhoun HM, Stevens LK et al. Parental history of hypertension and parental history of diabetes and microvascular complications in insulin-dependent diabetes mellitus: the EURODIAB IDDM Complications Study. Diabet Med 1998; 15 (05) 418-426 http://www.ncbi.nlm.nih.gov/pubmed/9609365
- 150 Seaquist ER, Goetz FC, Rich S et al. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320 (18) 1161-1165 http://www.ncbi.nlm.nih.gov/pubmed/2710189
- 151 Sinclair SH, Malamut R, Delvecchio C et al. Diabetic retinopathy: treating systemic conditions aggressively can save sight. Cleve Clin J Med 2005; 72 (05) 447-454 http://www.ncbi.nlm.nih.gov/pubmed/15929458
- 152 Chaturvedi N, Stephenson JM, Fuller JH. The relationship between smoking and microvascular complications in the EURODIAB IDDM Complications Study. Diabetes Care 1995; 18 (06) 785-792 http://www.ncbi.nlm.nih.gov/pubmed/7555504
- 153 Laakso M. Epidemiology of diabetic dyslipidaemia. Diabetes Rev 1995; 3: 40-42
- 154 Taskinen MR, Smith U. Lipid disorders in NIDDM: implications for treatment. J Intern Med 1998; 244 (05) 361-370 http://www.ncbi.nlm.nih.gov/pubmed/9845851
- 155 Stern MP, Haffner SM. Dyslipidemia in type II diabetes. Implications for therapeutic intervention. Diabetes Care 1991; 14 (12) 1144-1159 http://www.ncbi.nlm.nih.gov/pubmed/1773701
- 156 Lahdenpera S, Syvanne M, Kahri J et al. Regulation of low-density lipoprotein particle size distribution in NIDDM and coronary disease: importance of serum triglycerides. Diabetologia 1996; 39 (04) 453-461 http://www.ncbi.nlm.nih.gov/pubmed/8777995
- 157 Tschöpe D, Rösen P. Gerinnungsstörungen bei metabolischem Syndrom und Typ 2 Diabetes. In: Mehnert H, editor. Herz, Gefäße und Diabetes. München: Medicon Verl; 1997: 117-132
- 158 Janka HU. Thrombozytenfunktion bei diabetischer Angiopathie. Stuttgart: Thieme; 1983
- 159 Gries FA, Peterson Braun M, Tschöpe D et al. Haemostasis and diabetic angiopathy. Stuttgart: Thieme; 1993
- 160 Colwell JA. Vascular thrombosis in type II diabetes mellitus. Diabetes 1993; 42 (01) 8-11 http://www.ncbi.nlm.nih.gov/pubmed/8420821
- 161 Chan P, Pan WH. Coagulation activation in type 2 diabetes mellitus: the higher coronary risk of female diabetic patients. Diabet Med 1995; 12 (06) 504-507 http://www.ncbi.nlm.nih.gov/pubmed/7648824
- 162 Carter AM, Grant PJ. Vascular homeostasis, adhesion molecules, and macrovascular disease in non-insulin-dependent diabetes mellitus. Diabet Med 1997; 14 (06) 423-432 http://www.ncbi.nlm.nih.gov/pubmed/9212306
- 163 American Diabetes Association (ADA). Aspirin therapy in diabetes. Diabetes Care 2000; 23 (Suppl. 01) S61-S62 http://www.ncbi.nlm.nih.gov/pubmed/12017681
- 164 Colhoun HM, Betteridge DJ, Durrington PN et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 2004; 364 (9435) 685-696 http://www.ncbi.nlm.nih.gov/pubmed/15325833
- 165 Gries FA, Bruns W, Grüneklee D. Therapieziele und Behandlungsstrategien beim Diabetes mellitus. Diabet Stoffw 2002; 11: 3-4
- 166 American Diabetes Association (ADA). Diagnosis and classification of diabetes mellitus. Diabetes Care 2004; 27 Suppl 1: S5-S10 http://www.ncbi.nlm.nih.gov/pubmed/14693921
- 167 European Diabetes Policy Group. A desktop guide to Type 2 diabetes mellitus. European Diabetes Policy Group 1999. Diabet Med 1999; 16 (09) 716-730 http://www.ncbi.nlm.nih.gov/pubmed/10510947
- 168 Scherbaum WA, Lauterbach K, Joost HG. Deutsche Diabetes Gesellschaft (DDG) (eds.). Definition, Klassifikation und Diagnostik des Diabetes mellitus. Evidenzbasierte Diabetes-Leitlinien DDG. Düsseldorf: DDG; 2001
- 169 Tuomilehto J, Lindstrom J, Eriksson JG et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344 (18) 1343-1350 http://www.ncbi.nlm.nih.gov/pubmed/11333990
- 170 Kerner W, Brückel J. Definition, Klassifikation und Diagnostik des Diabetes mellitus. Diabet Stoffw 2010; 5 (Suppl. 02) S109-S112
- 171 Sacks DB, Arnold M, Bakris GL et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 2011; 34 (06) e61-e99 http://www.ncbi.nlm.nih.gov/pubmed/21617108
- 172 Feskens EJ, Bowles CH, Kromhout D. Intra- and interindividual variability of glucose tolerance in an elderly population. J Clin Epidemiol 1991; 44 (09) 947-953 http://www.ncbi.nlm.nih.gov/pubmed/1890437
- 173 Mooy JM, Grootenhuis PA, de Vries H et al. Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study. Diabetologia 1996; 39 (03) 298-305 http://www.ncbi.nlm.nih.gov/pubmed/8721775
- 174 Burke JP, Haffner SM, Gaskill SP et al. Reversion from type 2 diabetes to nondiabetic status. Influence of the 1997 American Diabetes Association criteria. Diabetes Care 1998; 21 (08) 1266-70 http://www.ncbi.nlm.nih.gov/pubmed/9702431
- 175 Ko GT, Chan JC, Woo J et al. The reproducibility and usefulness of the oral glucose tolerance test in screening for diabetes and other cardiovascular risk factors. Ann Clin Biochem 1998; 35 (01) 62-67 http://www.ncbi.nlm.nih.gov/pubmed/9463740
- 176 Schousboe K, Henriksen JE, Kyvik KO et al. Reproducibility of S-insulin and B-glucose responses in two identical oral glucose tolerance tests. Scand J Clin Lab Invest 2002; 62 (08) 623-630 http://www.ncbi.nlm.nih.gov/pubmed/12564620
- 177 Sievenpiper JL, Leiter LA, Vuksan V. Intrasubject coefficient of variation corresponds to diagnostic reproducibility in diabetes screening. Can J Diab 2002; 26: 105-112
- 178 de Vegt F, Dekker JM, Stehouwer CD et al. Similar 9-year mortality risks and reproducibility for the World Health Organization and American Diabetes Association glucose tolerance categories: the Hoorn Study. Diabetes Care 2000; 23 (01) 40-44 http://www.ncbi.nlm.nih.gov/pubmed/10857966
- 179 Kulzer B, Albus C, Herpertz S. Psychosoziales und Diabetes mellitus; DDG Praxis Leitlinie. Diabet Stoffw 2007; 2: S178-S183
- 180 Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 2008; 4 (04) 200-213 http://www.ncbi.nlm.nih.gov/pubmed/18301398
- 181 Meissner T, Marquard J, Schober E. Maturity-onset diabetes of the young (MODY). Diabetologe 2010; 6 (03) 219-230
- 182 Keller H, Kramer L, Krones T et al. Evaluation der Implementierung von Innovationen am Beispiel von arriba® – eine Fokusgruppenstudie. Z Allg Med 2011; (01) 35-41
- 183 Sadowski EM, Eimer C, Keller H et al. Evaluation komplexer Interventionen: Implementierung von ARRIBA-Herz?. einer Beratungsstrategie für die Herz-Kreislaufprävention. ZFA 2005; 81 (10) 429-434
- 184 Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP). JAMA 2001; 285 (19) 2486-2497 http://www.ncbi.nlm.nih.gov/pubmed/11368702
- 185 Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002; 105 (03) 310-315 http://www.ncbi.nlm.nih.gov/pubmed/11804985
- 186 Hippisley-Cox J, Coupland C, Vinogradova Y et al. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ 2008; 336 (7659) 1475-1482 http://www.ncbi.nlm.nih.gov/pubmed/18573856
- 187 Keil U, Fitzgerald AP, Gohlke H et al. Risikoabschätzung tödlicher Herz-Kreislauf-Erkrankungen. Die neuen SCORE-Deutschland-Tabellen für die Primärprävention. Dtsch Arztebl 2005; 102 (25) A1808-A1812
- 188 Stevens RJ, Kothari V, Adler AI et al. The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56). Clin Sci (Lond) 2001; 101 (06) 671-679 http://www.ncbi.nlm.nih.gov/pubmed/11724655
- 189 Deutsches Institut für Ernährungsforschung Potsdam Rehbrücke (DIfE). Deutscher Diabetes-Risiko-Test® . 2007 [cited: 2013 Jul 04]. Available from: http://drs.dife.de/
- 190 Deutsche Diabetes-Stiftung (DDS). GesundheitsCheck Diabetes FINDRISK. 2007 [cited: 2013 Jul 04]. Available from: http://www.diabetes-risiko.de/risikotest.html
- 191 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Typ-2-Diabetes. Präventions- und Behandlungsstrategien für Fußkomplikationen. Langfassung. Mainz: Kirchheim; 2009 Available from: http://www.versorgungsleitlinien.de/themen/diabetes2/dm2_fuss/pdf/nvl_t2dfuss_lang.pdf
- 192 Whooley MA, Avins AL, Miranda J et al. Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med 1997; 12 (07) 439-445 http://www.ncbi.nlm.nih.gov/pubmed/9229283
- 193 World Health Organization (WHO). WHO (Fünf) – Fragebogen zum Wohlbefinden (Version 1998). 1998 [cited: 2013 Aug 12]. Available from: http://www.cure4you.dk/354/WHO-5_German.pdf
- 194 Turner RC, Cull CA, Frighi V et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999; 281 (21) 2005-12 http://www.ncbi.nlm.nih.gov/pubmed/10359389
- 195 International Diabetes Federation (IDF). Self-Monitoring of Blood Glucose in Non-Insulin Treated Type 2 Diabetes. Guideline. 2009 [cited: 2013 Jul 04]. Available from: http://www.idf.org/webdata/docs/SMBG_EN2.pdf
- 196 Brown SA. Studies of educational interventions and outcomes in diabetic adults: a meta-analysis revisited. Patient Educ Couns 1990; 16 (03) 189-215 http://www.ncbi.nlm.nih.gov/pubmed/2149753
- 197 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Urin- und Blutzuckerselbstmessung bei Diabetes mellitus Typ 2. Abschlussbericht. Auftrag A05-08. Version 1.0. 2009 [cited: 2013 Apr 23]. Available from: http://www.iqwig.de/download/A05-08_Abschlussbericht_Zuckerselbstmessung_bei_Diabetes_mellitus_Typ_2.pdf
- 198 Clar C, Barnard K, Cummins E et al. Self-monitoring of blood glucose in type 2 diabetes: systematic review. Health Technol Assess 2010; 14 (12) 1-140 http://www.ncbi.nlm.nih.gov/pubmed/20226138
- 199 Müller N, Stengel D, Kloos C et al. Improvement of HbA1c and stable weight loss two years after an outpatient treatment and teaching programme for patients with type 2 diabetes without insulin therapy based on urine glucose self monitoring. Int J Gen Med 2012; (05) 241-247
- 200 Mann JI, De Leeuw I, Hermansen K et al. Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis 2004; 14 (06) 373-394 http://www.ncbi.nlm.nih.gov/pubmed/15853122
- 201 National Institute for Clinical Excellence (NICE). Type 2 Diabetes. National clinical guideline for management in primary and secondary care (update). London: Royal College Of Physicians; 2008 Available from: http://www.nice.org.uk/nicemedia/live/11983/40803/40803.pdf
- 202 Standards of medical care in diabetes – 2013. Diabetes Care 2013; 36 (Suppl. 01) S11-S66 http://www.ncbi.nlm.nih.gov/pubmed/23264422
- 203 Pastors JG, Franz MJ, Warshaw H et al. How effective is medical nutrition therapy in diabetes care?. J Am Diet Assoc 2003; 103 (07) 827-831 http://www.ncbi.nlm.nih.gov/pubmed/12830019
- 204 Pastors JG, Warshaw H, Daly A et al. The evidence for the effectiveness of medical nutrition therapy in diabetes management. Diabetes Care 2002; 25 (03) 608-613 http://www.ncbi.nlm.nih.gov/pubmed/11874956
- 205 UK Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients, UKPDS Group. Metabolism 1990; 39 (09) 905-912 http://www.ncbi.nlm.nih.gov/pubmed/2392060
- 206 Franz MJ, Monk A, Barry B et al. Effectiveness of medical nutrition therapy provided by dietitians in the management of non-insulin-dependent diabetes mellitus: a randomized, controlled clinical trial. J Am Diet Assoc 1995; 95 (09) 1009-1017 http://www.ncbi.nlm.nih.gov/pubmed/7657902
- 207 Moore H, Summerbell C, Hooper L et al. Dietary advice for treatment of type 2 diabetes mellitus in adults. Cochrane Database Syst Rev 2004; (03) CD004097 http://www.ncbi.nlm.nih.gov/pubmed/15266517
- 208 Brown SA, Upchurch S, Anding R et al. Promoting weight loss in type II diabetes. Diabetes Care 1996; 19 (06) 613-624 http://www.ncbi.nlm.nih.gov/pubmed/8725861
- 209 Norris SL, Engelgau MM, Narayan KM. Effectiveness of self-management training in type 2 diabetes: a systematic review of randomized controlled trials. Diabetes Care 2001; 24 (03) 561-587 http://www.ncbi.nlm.nih.gov/pubmed/11289485
- 210 Dyson PA, Kelly T, Deakin T et al. Diabetes UK evidence-based nutrition guidelines for the prevention and management of diabetes. Diabet Med 2011; 28 (11) 1282-1288 http://www.ncbi.nlm.nih.gov/pubmed/21699560
- 211 de Souza RJ, Swain JF, Appel LJ et al. Alternatives for macronutrient intake and chronic disease: a comparison of the OmniHeart diets with popular diets and with dietary recommendations. Am J Clin Nutr 2008; 88 (01) 1-11 http://www.ncbi.nlm.nih.gov/pubmed/18614716
- 212 Sacks FM, Bray GA, Carey VJ et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 2009; 360 (09) 859-873 http://www.ncbi.nlm.nih.gov/pubmed/19246357
- 213 Toeller M, Müller-Wieland D. Keine speziellen diätetischen Lebensmittel mehr für Personen mit Diabetes mellitus. Diab Stoffw 2011; 6 (01) 29-31
- 214 Jenkins DJ, Wolever TM, Taylor RH et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 1981; 34 (03) 362-366 http://www.ncbi.nlm.nih.gov/pubmed/6259925
- 215 Brand-Miller J, Hayne S, Petocz P et al. Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care 2003; 26 (08) 2261-2267 http://www.ncbi.nlm.nih.gov/pubmed/12882846
- 216 Anderson JW, Randles KM, Kendall CW et al. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J Am Coll Nutr 2004; 23 (01) 5-17 http://www.ncbi.nlm.nih.gov/pubmed/14963049
- 217 Wolever TM, Gibbs AL, Mehling C et al. The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein. Am J Clin Nutr 2008; 87 (01) 114-125 http://www.ncbi.nlm.nih.gov/pubmed/18175744
- 218 Thomas DE, Elliott EJ. The use of low-glycaemic index diets in diabetes control. Br J Nutr 2010; 104 (06) 797-802 http://www.ncbi.nlm.nih.gov/pubmed/20420752
- 219 Hu FB, van Dam RM, Liu S. Diet and risk of Type II diabetes: the role of types of fat and carbohydrate. Diabetologia 2001; 44 (07) 805-817 http://www.ncbi.nlm.nih.gov/pubmed/11508264
- 220 Summers LK, Fielding BA, Bradshaw HA et al. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia 2002; 45 (03) 369-377 http://www.ncbi.nlm.nih.gov/pubmed/11914742
- 221 Salmeron J, Hu FB, Manson JE et al. Dietary fat intake and risk of type 2 diabetes in women. Am J Clin Nutr 2001; 73 (06) 1019-1026 http://www.ncbi.nlm.nih.gov/pubmed/11382654
- 222 Kasiske BL, Lakatua JD, Ma JZ et al. A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. Am J Kidney Dis 1998; 31 (06) 954-961 http://www.ncbi.nlm.nih.gov/pubmed/9631839
- 223 Pedrini MT, Levey AS, Lau J et al. The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Ann Intern Med 1996; 124 (07) 627-632 http://www.ncbi.nlm.nih.gov/pubmed/8607590
- 224 Robertson L, Waugh N, Robertson A. Protein restriction for diabetic renal disease. Cochrane Database Syst Rev 2007; (04) CD002181 http://www.ncbi.nlm.nih.gov/pubmed/17943769
- 225 Austin GL, Ogden LG, Hill JO. Trends in carbohydrate, fat, and protein intakes and association with energy intake in normal-weight, overweight, and obese individuals: 1971–2006. Am J Clin Nutr 2011; 93 (04) 836-843 http://www.ncbi.nlm.nih.gov/pubmed/21310830
- 226 Executive summary: Standards of medical care in diabetes-2012. Diabetes Care 2012; 35 (Suppl. 01) S4-S10 http://www.ncbi.nlm.nih.gov/pubmed/22187471
- 227 Toeller M. Lifestyle Issues: Diet. In: Holt RIG, Cockram CS, Flyvbjerg A, Goldstein BJ, editors. Textbook of Diabetes. New York: Wiley; 2010: 346-357
- 228 Toeller M, Mann JI. Nutrition in the etiology and management of type 2 diabetes. In: Goldstein BJ, Müller-Wieland D, editors. Type 2 Diabetes. Principles and Practice. 2nd ed. New York: Informa Healthcare; 2008
- 229 Benack E, Gerlach S, Joost HG. Stellungnahme von diabetesDE und VDBD zu Stevia. 2012 [cited: 2013 Jun 26]. Available from: http://www.vdbd.de/Verband/Stellungnahme_diabetesDE_VDBD_Stevia_17-01-12.pdf
- 230 Greaves CJ, Sheppard KE, Abraham C et al. Systematic review of reviews of intervention components associated with increased effectiveness in dietary and physical activity interventions. BMC Public Health 2011; 11: 119 http://www.ncbi.nlm.nih.gov/pubmed/21333011
- 231 Paulweber B, Valensi P, Lindstrom J et al. A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res 2010; 42 (Suppl. 01) S3-S36 http://www.ncbi.nlm.nih.gov/pubmed/20391306
- 232 National Institutes of Health (NIH). Weight loss does not lower heart disease risk from type 2 diabetes. [press release] 2012 [cited: 2013 Jun 26]. Available from: http://www.nih.gov/news/health/oct2012/niddk-19.htm
- 233 Wadden TA, Neiberg RH, Wing RR et al. Four-Year Weight Losses in the Look AHEAD Study: Factors Associated With Long-Term Success. Obesity (Silver Spring) 2011; http://www.ncbi.nlm.nih.gov/pubmed/21779086
- 234 Wing RR, Lang W, Wadden TA et al. Benefits of Modest Weight Loss in Improving Cardiovascular Risk Factors in Overweight and Obese Individuals With Type 2 Diabetes. Diabetes Care 2011; 34 (07) 1481-1486 http://www.ncbi.nlm.nih.gov/pubmed/21593294
- 235 Belalcazar LM, Ballantyne CM, Lang W et al. Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the look AHEAD study. Arterioscler Thromb Vasc Biol 2011; 31 (07) 1689-1695 http://www.ncbi.nlm.nih.gov/pubmed/21512162
- 236 Stewart TM, Bachand AR, Han H et al. Body image changes associated with participation in an intensive lifestyle weight loss intervention. Obesity (Silver Spring) 2011; 19 (06) 1290-1295 http://www.ncbi.nlm.nih.gov/pubmed/21151020
- 237 Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med 2010; 170 (17) 1566-1575 http://www.ncbi.nlm.nih.gov/pubmed/20876408
- 238 Wing RR, Bolin P, Brancati FL et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013; 369 (02) 145-154 http://www.ncbi.nlm.nih.gov/pubmed/23796131
- 239 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Steigerung der körperlichen Aktivität bei Diabetes mellitus Typ 2. Rapid Report A05-06A. Version 1.0. 2011 [cited: 2013 Jun 26]. Available from: https://www.iqwig.de/download/A05-06A_Kurzfassung_RR_Steigerung_der_koerperlichen_Aktivitaet_bei_Diabetes_mellitus_Typ_2.pdf
- 240 Colberg SR, Sigal RJ, Fernhall B et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010; 33 (12) e147-e167 http://www.ncbi.nlm.nih.gov/pubmed/21115758
- 241 Boule NG, Haddad E, Kenny GP et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 2001; 286 (10) 1218-1227 http://www.ncbi.nlm.nih.gov/pubmed/11559268
- 242 Boule NG, Kenny GP, Haddad E et al. Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus. Diabetologia 2003; 46 (08) 1071-1081 http://www.ncbi.nlm.nih.gov/pubmed/12856082
- 243 Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006; 29 (11) 2518-2527 http://www.ncbi.nlm.nih.gov/pubmed/17065697
- 244 Nielsen PJ, Hafdahl AR, Conn VS et al. Meta-analysis of the effect of exercise interventions on fitness outcomes among adults with type 1 and type 2 diabetes. Diabetes Res Clin Pract 2006; 74 (02) 111-120 http://www.ncbi.nlm.nih.gov/pubmed/16735074
- 245 Boule NG, Weisnagel SJ, Lakka TA et al. Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes Care 2005; 28 (01) 108-114 http://www.ncbi.nlm.nih.gov/pubmed/15616242
- 246 King DS, Baldus PJ, Sharp RL et al. Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. J Appl Physiol 1995; 78 (01) 17-22 http://www.ncbi.nlm.nih.gov/pubmed/7713807
- 247 Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report. Washington, DC: U. S. Department of Health and Human Services; 2008 Available from: http://www.health.gov/paguidelines/report/pdf/CommitteeReport.pdf
- 248 Castaneda C, Layne JE, Munoz-Orians L et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002; 25 (12) 2335-2341 http://www.ncbi.nlm.nih.gov/pubmed/12453982
- 249 Dunstan DW, Daly RM, Owen N et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 2002; 25 (10) 1729-1736 http://www.ncbi.nlm.nih.gov/pubmed/12351469
- 250 Sigal RJ, Kenny GP, Boule NG et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147 (06) 357-369 http://www.ncbi.nlm.nih.gov/pubmed/17876019
- 251 Cohen ND, Dunstan DW, Robinson C et al. Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes. Diabetes Res Clin Pract 2008; 79 (03) 405-411 http://www.ncbi.nlm.nih.gov/pubmed/18006170
- 252 Ibanez J, Gorostiaga EM, Alonso AM et al. Lower muscle strength gains in older men with type 2 diabetes after resistance training. J Diabetes Complications 2008; 22 (02) 112-118 http://www.ncbi.nlm.nih.gov/pubmed/18280441
- 253 Ishii T, Yamakita T, Sato T et al. Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake. Diabetes Care 1998; 21 (08) 1353-1355 http://www.ncbi.nlm.nih.gov/pubmed/9702447
- 254 Strasser B, Siebert U, Schobersberger W. Resistance training in the treatment of the metabolic syndrome: a systematic review and meta-analysis of the effect of resistance training on metabolic clustering in patients with abnormal glucose metabolism. Sports Med 2010; 40 (05) 397-415 http://www.ncbi.nlm.nih.gov/pubmed/20433212
- 255 König D, Deibert P, Dickhut HH et al. Krafttraining bei Diabetes mellitus Typ 2. Dtsch Z Sportmed 2011; 62: 5-9
- 256 Cuff DJ, Meneilly GS, Martin A et al. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003; 26 (11) 2977-2982 http://www.ncbi.nlm.nih.gov/pubmed/14578226
- 257 Marcus RL, Smith S, Morrell G et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Physical Therapy 2008; 88 (11) 1345-1354 http://www.ncbi.nlm.nih.gov/pubmed/18801851
- 258 Church TS, Blair SN, Cocreham S et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010; 304 (20) 2253-2262 http://www.ncbi.nlm.nih.gov/pubmed/21098771
- 259 Nelson ME, Rejeski WJ, Blair SN et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007; 39 (08) 1435-1445 http://www.ncbi.nlm.nih.gov/pubmed/17762378
- 260 Hollmann W, Strüder HK, Tagarakis CV. Körperliche Aktivität, Gehirngesundheit und -leistungsfähigkeit. Nervenheilkunde 2003; 22 (09) 467-474
- 261 Marwick TH, Hordern MD, Miller T et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009; 119 (25) 3244-3262 http://www.ncbi.nlm.nih.gov/pubmed/19506108
- 262 Desai MY, Nasir K, Rumberger JA et al. Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factors. Am J Cardiol 2004; 94 (06) 729-732 http://www.ncbi.nlm.nih.gov/pubmed/15374775
- 263 Wackers FJ, Young LH, Inzucchi SE et al. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care 2004; 27 (08) 1954-1961 http://www.ncbi.nlm.nih.gov/pubmed/15277423
- 264 Balducci S, Zanuso S, Nicolucci A et al. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med 2010; 170 (20) 1794-1803 http://www.ncbi.nlm.nih.gov/pubmed/21059972
- 265 Bernbaum M, Albert SG, Cohen JD et al. Cardiovascular conditioning in individuals with diabetic retinopathy. Diabetes Care 1989; 12 (10) 740-742 http://www.ncbi.nlm.nih.gov/pubmed/2612306
- 266 Albert SG, Bernbaum M. Exercise for patients with diabetic retinopathy. Diabetes Care 1995; 18 (01) 130-132 http://www.ncbi.nlm.nih.gov/pubmed/7698034
- 267 Aiello LP, Wong J, Cavallerano J et al. Retinopathy. In: Ruderman N, Devlin JT, Kriska A, (eds.) Handbook of Exercise in Diabetes. 2nd ed. Alexandria: ADA; 2002: 401-413
- 268 Willi C, Bodenmann P, Ghali WA et al. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2007; 298 (22) 2654-2664 http://www.ncbi.nlm.nih.gov/pubmed/18073361
- 269 Willett WC, Green A, Stampfer MJ et al. Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes. N Engl J Med 1987; 317 (21) 1303-1309 http://www.ncbi.nlm.nih.gov/pubmed/3683458
- 270 Hjermann I, Velve BK, Holme I et al. Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men. Lancet 1981; 2 (8259) 1303-1310 http://www.ncbi.nlm.nih.gov/pubmed/6118715
- 271 Critchley J, Capewell S. Smoking cessation for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev 2004; (01) CD003041 http://www.ncbi.nlm.nih.gov/pubmed/14974003
- 272 Hermanson B, Omenn GS, Kronmal RA et al. Beneficial six-year outcome of smoking cessation in older men and women with coronary artery disease. Results from the CASS registry. . N Engl J Med 1988; 319 (21) 1365-1369 http://www.ncbi.nlm.nih.gov/pubmed/3185646
- 273 Doll R, Peto R, Boreham J et al. Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 2004; 328 (7455) 1519 http://www.ncbi.nlm.nih.gov/pubmed/15213107
- 274 Lancaster T, Stead L. Physician advice for smoking cessation. Cochrane Database Syst Rev 2004; (04) CD000165 http://www.ncbi.nlm.nih.gov/pubmed/15494989
- 275 Fichtenberg CM, Glantz SA. Effect of smoke-free workplaces on smoking behaviour: systematic review. BMJ 2002; 325 (7357) 188 http://www.ncbi.nlm.nih.gov/pubmed/12142305
- 276 Multiple Risk Factor Intervention Trial Research Group. Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982; 248 (12) 1465-1477 http://www.ncbi.nlm.nih.gov/pubmed/7050440
- 277 Peto R, Darby S, Deo H et al. Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000; 321 (7257) 323-329 http://www.ncbi.nlm.nih.gov/pubmed/10926586
- 278 Singh S, Loke YK, Spangler JG et al. Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis. CMAJ 2011; 183 (12) 1359-1366 http://www.ncbi.nlm.nih.gov/pubmed/21727225
- 279 Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin (DGP). Tabakentwöhnung bei COPD. Pneumologie 2008; 62: 255-272
- 280 Fiore MC, Jaén CR, Baker TB. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville: U. S. Department of Health and Human Services. Public Health Service; 2008
- 281 UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance. Diabetologia 1991; 34 (12) 877-890 http://www.ncbi.nlm.nih.gov/pubmed/1778353
- 282 Inzucchi SE, Bergenstal RM, Buse JB et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012; 55 (06) 1577-1596 http://www.ncbi.nlm.nih.gov/pubmed/22526604
- 283 Bolen S, Feldman L, Vassy J et al. Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med 2007; 147 (06) 386-399 http://www.ncbi.nlm.nih.gov/pubmed/17638715
- 284 Holstein A, Patzer OM, Machalke K et al. Substantial increase in incidence of severe hypoglycemia between 1997–2000 and 2007–2010: a German longitudinal population-based study. Diabetes Care 2012; 35 (05) 972-975 http://www.ncbi.nlm.nih.gov/pubmed/22410817
- 285 Holman RR, Paul SK, Bethel MA et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359 (15) 1577-1589 http://www.ncbi.nlm.nih.gov/pubmed/18784090
- 286 Kooy A, de Jager J, Lehert P et al. Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus. Arch Intern Med 2009; 169 (06) 616-625 http://www.ncbi.nlm.nih.gov/pubmed/19307526
- 287 Ewart RM. The case against aggressive treatment of type 2 diabetes: critique of the UK prospective diabetes study. BMJ 2001; 323 (7317) 854-858 http://www.ncbi.nlm.nih.gov/pubmed/11597972
- 288 Holman A, Matthews EA, Meade T. Commentary: UKPDS is well designed and clinically important. BMJ 2001; 323: 857-888
- 289 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Nutzenbewertung einer langfristigen, normnahen Blutzuckersenkung bei Patienten mit Diabetes mellitus Typ 2. Rapid Report. Auftrag A05-07. Version 1.0. 2011 [cited: 2013 Jul 04]. Available from: https://www.iqwig.de/download/A05-07_Rapid-Report_Normnahe-Blutzuckersenkung-bei-Diabetes-mellitus-Typ-2.pdf
- 290 Mühlhauser I. UKPDS – Darstellung nach Evidence-based Medicine Kriterien. 2011 [cited: 2013 Jul 04]. Available from: http://user.meduni-graz.at/andrea.berghold/EBM/UKPDS_bewertung.pdf
- 291 Nathan DM. Some answers, more controversy, from UKPDS. United Kingdom Prospective Diabetes Study. Lancet 1998; 352 (9131) 832-832 http://www.ncbi.nlm.nih.gov/pubmed/9742972
- 292 Bachmann W, Löbe A, Lacher F. Medikamentös bedingte Hypoglykämien bei Typ-II-Diabetes. Diab Stoffw 1995; 4: 83-89
- 293 Holstein A, Plaschke A, Egberts EH. Incidence and costs of severe hypoglycemia. Diabetes Care 2002; 25 (11) 2109-2110 http://www.ncbi.nlm.nih.gov/pubmed/12401771
- 294 Holstein A, Egberts EH. Risk of hypoglycaemia with oral antidiabetic agents in patients with Type 2 diabetes. Exp Clin Endocrinol Diabetes 2003; 111 (07) 405-414 http://www.ncbi.nlm.nih.gov/pubmed/14614647
- 295 Holstein A, Plaschke A, Egberts EH. Clinical characterisation of severe hypoglycaemia--a prospective population-based study. Exp Clin Endocrinol Diabetes 2003; 111 (06) 364-369 http://www.ncbi.nlm.nih.gov/pubmed/14520604
- 296 Holstein A, Plaschke A, Hammer C et al. Characteristics and time course of severe glimepiride- versus glibenclamide-induced hypoglycaemia. Eur J Clin Pharmacol 2003; 59 (02) 91-97 http://www.ncbi.nlm.nih.gov/pubmed/12698302
- 297 UK Hypoglycemia Study Group. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 2007; 50 (06) 1140-1147 http://www.ncbi.nlm.nih.gov/pubmed/17415551.
- 298 Holstein A, Hammer C, Hahn M et al. Severe sulfonylurea-induced hypoglycemia: a problem of uncritical prescription and deficiencies of diabetes care in geriatric patients. Expert Opin Drug Saf 2010; 9 (05) 675-681 http://www.ncbi.nlm.nih.gov/pubmed/20553106
- 299 Zoungas S, Patel A, Chalmers J et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med 2010; 363 (15) 1410-1418 http://www.ncbi.nlm.nih.gov/pubmed/20925543
- 300 Budnitz DS, Lovegrove MC, Shehab N et al. Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med 2011; 365 (21) 2002-2012 http://www.ncbi.nlm.nih.gov/pubmed/22111719
- 301 Holstein A. Impact of renal impairment on the risk of severe hypoglycaemia associated with the use of insulin and glyburide. Nephrol Dial Transplant 2011; 26 (05) 1748-1749 http://www.ncbi.nlm.nih.gov/pubmed/21372261
- 302 Qaseem A, Humphrey LL, Sweet DE et al. Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2012; 156 (03) 218-231 http://www.ncbi.nlm.nih.gov/pubmed/22312141
- 303 Wright A, Burden AC, Paisey RB et al. Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U. K. Prospective Diabetes Study (UKPDS 57). Diabetes Care 2002; 25 (02) 330-336 http://www.ncbi.nlm.nih.gov/pubmed/11815505
- 304 Cook MN, Girman CJ, Stein PP et al. Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes. Diabetes Care 2005; 28 (05) 995-1000 http://www.ncbi.nlm.nih.gov/pubmed/15855556
- 305 Evans JM, Ogston SA, Emslie-Smith A et al. Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 2006; 49 (05) 930-936 http://www.ncbi.nlm.nih.gov/pubmed/16525843
- 306 Monami M, Balzi D, Lamanna C et al. Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality. Diabetes Metab Res Rev 2007; 23 (06) 479-484 http://www.ncbi.nlm.nih.gov/pubmed/17385195
- 307 Eurich DT, McAlister FA, Blackburn DF et al. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ 2007; 335 (7618) 497 http://www.ncbi.nlm.nih.gov/pubmed/17761999
- 308 Tzoulaki I, Molokhia M, Curcin V et al. Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. BMJ 2009; 339: b4731 http://www.ncbi.nlm.nih.gov/pubmed/19959591
- 309 Zeller M, Danchin N, Simon D et al. Impact of type of preadmission sulfonylureas on mortality and cardiovascular outcomes in diabetic patients with acute myocardial infarction. J Clin Endocrinol Metab 2010; 95 (11) 4993-5002 http://www.ncbi.nlm.nih.gov/pubmed/20702526
- 310 Jorgensen CH, Gislason GH, Andersson C et al. Effects of oral glucose-lowering drugs on long term outcomes in patients with diabetes mellitus following myocardial infarction not treated with emergent percutaneous coronary intervention--a retrospective nationwide cohort study. Cardiovasc Diabetol 2010; 9: 54 http://www.ncbi.nlm.nih.gov/pubmed/20843380
- 311 Andersson C, Olesen JB, Hansen PR et al. Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study. Diabetologia 2010; 53 (12) 2546-2553 http://www.ncbi.nlm.nih.gov/pubmed/20838985
- 312 Azoulay L, Schneider-Lindner V, Dell'aniello S et al. Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control study. Pharmacoepidemiol Drug Saf 2010; 19 (04) 335-342 http://www.ncbi.nlm.nih.gov/pubmed/20052677
- 313 Schramm TK, Gislason GH, Vaag A et al. Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study. Eur Heart J 2011; 32 (15) 1900-1908 http://www.ncbi.nlm.nih.gov/pubmed/21471135
- 314 Pantalone KM, Kattan MW, Yu C et al. The risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy: a retrospective analysis. Diabetes Care 2010; 33 (06) 1224-1229 http://www.ncbi.nlm.nih.gov/pubmed/20215447
- 315 Forst T, Hanefeld M, Jacob S et al. Association of sulfonylurea treatment with all-cause and cardiovascular mortality: a systematic review and meta-analysis of observational studies. Diab Vasc Dis Res 2013; 10 (04) 302-314 http://www.ncbi.nlm.nih.gov/pubmed/23291340
- 316 Rao AD, Kuhadiya N, Reynolds K et al. Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies. Diabetes Care 2008; 31 (08) 1672-1678 http://www.ncbi.nlm.nih.gov/pubmed/18458139
- 317 Lamanna C, Monami M, Marchionni N et al. Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2011; 13 (03) 221-228 http://www.ncbi.nlm.nih.gov/pubmed/21205121
- 318 Shichiri M, Kishikawa H, Ohkubo Y et al. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 2000; 23 Suppl 2: B21-B29 http://www.ncbi.nlm.nih.gov/pubmed/10860187
- 319 Esposito K, Chiodini P, Bellastella G et al. Proportion of patients at HbA1c target <7% with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78 945 patients. Diabetes Obes Metab 2012; 14 (03) 228-233 http://www.ncbi.nlm.nih.gov/pubmed/21958121
- 320 Holstein A, Plaschke A, Egberts EH. Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide. Diabetes Metab Res Rev 2001; 17 (06) 467-473 http://www.ncbi.nlm.nih.gov/pubmed/11757083
- 321 Saenz A, Fernandez-Esteban I, Mataix A et al. Metformin monotherapy for type 2 diabetes mellitus. Cochrane Database Syst Rev 2005; (03) CD002966 http://www.ncbi.nlm.nih.gov/pubmed/16034881
- 322 Ong CR, Molyneaux LM, Constantino MI et al. Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes. Diabetes Care 2006; 29 (11) 2361-2364 http://www.ncbi.nlm.nih.gov/pubmed/17065668
- 323 Ito H, Ishida H, Takeuchi Y et al. Long-term effect of metformin on blood glucose control in non-obese patients with type 2 diabetes mellitus. Nutr Metab (Lond) 2010; 7: 83 http://www.ncbi.nlm.nih.gov/pubmed/21070671
- 324 Lipska KJ, Bailey CJ, Inzucchi SE. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 2011; 34 (06) 1431-1437 http://www.ncbi.nlm.nih.gov/pubmed/21617112
- 325 Heumann. Metformin Fachinformation. Stand der Information: Januar 2011 2011 [cited: 2012 Aug 16]. Available from: http://www.fachinfo.de
- 326 Senior PA. Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice. Diabet Med 2012; 29 (02) 161-163 http://www.ncbi.nlm.nih.gov/pubmed/21978280
- 327 Elashoff M, Matveyenko AV, Gier B et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011; 141 (01) 150-156 http://www.ncbi.nlm.nih.gov/pubmed/21334333
- 328 Singh S, Chang HY, Richards TM et al. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study. JAMA Intern Med 2013; 173 (07) 534-539 http://www.ncbi.nlm.nih.gov/pubmed/23440284
- 329 Butler AE, Campbell-Thompson M, Gurlo T et al. Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with increased Exocrine Pancreas Dysplasia and the potential for Glucagon-producing Neuroendocrine Tumors. Diabetes 2013; http://www.ncbi.nlm.nih.gov/pubmed/23524641
- 330 AstraZeneca, Bristol-Myers Squibb. Forxiga®, Dapagliflozin. Fachinformation, Stand November 2012. 2012 [cited: 2013 Jul 03]. Available from: http://www.fachinfo.de
- 331 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Forxiga® (Dapagliflozin). Neue Arzneimittel. Information der Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). 2013 [cited: 2013 Jul 03]. Available from: http://www.akdae.de/Arzneimitteltherapie/NA/Archiv/201302-Forxiga.pdf
- 332 McIntosh B, Cameron C, Singh SR et al. Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis. Open Med 2011; 5 (01) e35-e48 http://www.ncbi.nlm.nih.gov/pubmed/22046219
- 333 Gross JL, Kramer CK, Leitao CB et al. Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis. Ann Intern Med 2011; 154 (10) 672-679 http://www.ncbi.nlm.nih.gov/pubmed/21576535
- 334 Haupt E. Blutzuckersenkende Sulfonamide. Weinheim: Verl. Chemie; 1977
- 335 Thoelke H, Ratzmann KP. Häufigkeit des Sekundarversagens einer Sulfonylharnstofftherapie. Epidemiologische Untersuchung. . Dtsch Med Wochenschr 1989; 114 (15) 580-583 http://www.ncbi.nlm.nih.gov/pubmed/2649348
- 336 Shen SW, Bressler R. Clinical pharmacology of oral antidiabetic agents (second of two parts). N Engl J Med 1977; 296 (14) 787-793 http://www.ncbi.nlm.nih.gov/pubmed/320484
- 337 Pfeiffer EF, Schöffling K, Steigerwald H et al. Das Problem des Sekundärversagens der oralen Diabetesbehandlung. Dtsch Med Wochenschr 1957; 82 (36) 1528-1531 http://www.ncbi.nlm.nih.gov/pubmed/13473486.
- 338 Calvert MJ, McManus RJ, Freemantle N. Management of type 2 diabetes with multiple oral hypoglycaemic agents or insulin in primary care: retrospective cohort study. Br J Gen Pract 2007; 57 (539) 455-460 http://www.ncbi.nlm.nih.gov/pubmed/17550670
- 339 Hother-Nielsen O, Faber O, Sorensen NS et al. Classification of newly diagnosed diabetic patients as insulin-requiring or non-insulin-requiring based on clinical and biochemical variables. Diabetes Care 1988; 11 (07) 531-537 http://www.ncbi.nlm.nih.gov/pubmed/3203569
- 340 Sarlund H, Siitonen O, Laakso M et al. Repeatability of C-peptide response in glucagon stimulation test. Acta Endocrinol (Copenh) 1987; 114 (04) 515-518 http://www.ncbi.nlm.nih.gov/pubmed/3577583
- 341 Niskanen L, Karjalainen J, Sarlund H et al. Five-year follow-up of islet cell antibodies in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991; 34 (06) 402-408 http://www.ncbi.nlm.nih.gov/pubmed/1884898
- 342 Groop LC, Bottazzo GF, Doniach D. Islet cell antibodies identify latent type I diabetes in patients aged 35–75 years at diagnosis. Diabetes 1986; 35 (02) 237-241 http://www.ncbi.nlm.nih.gov/pubmed/3510930
- 343 Riddle MC, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care 2003; 26 (11) 3080-3086 http://www.ncbi.nlm.nih.gov/pubmed/14578243
- 344 Goudswaard AN, Furlong NJ, Rutten GE et al. Insulin monotherapy versus combinations of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitus. Cochrane Database Syst Rev 2004; (04) CD003418 http://www.ncbi.nlm.nih.gov/pubmed/15495054
- 345 Turner R, Cull C, Holman R. United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus. Ann Intern Med 1996; 124 (01) 136-145 http://www.ncbi.nlm.nih.gov/pubmed/8554206
- 346 Yki-Jarvinen H, Nikkila K, Rygsby L. Comparison of bed-time insulin regimens in NIDDM: Metformin prevents insulin-induced weight gain. Abstract 33. Diabetologia 1996; 39 (Suppl. 01) 115
- 347 Williams G. Management of non-insulin-dependent diabetes mellitus. Lancet 1994; 343 (8889) 95-100 http://www.ncbi.nlm.nih.gov/pubmed/7903785
- 348 Hayward RA, Manning WG, Kaplan SH et al. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications, and resource utilization. JAMA 1997; 278 (20) 1663-1669 http://www.ncbi.nlm.nih.gov/pubmed/9388085
- 349 Garvey WT, Olefsky JM, Griffin J et al. The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 1985; 34 (03) 222-234 http://www.ncbi.nlm.nih.gov/pubmed/3882489
- 350 Andrews WJ, Vasquez B, Nagulesparan M et al. Insulin therapy in obese, non-insulin-dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal. Diabetes 1984; 33 (07) 634-642 http://www.ncbi.nlm.nih.gov/pubmed/6376219
- 351 UK Prospective Diabetes Study (UKPDS) Group. United Kingdom Prospective Diabetes Study 24: a 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy. United Kingdom Prospective Diabetes Study Group. Ann Intern Med 1998; 128 (03) 165-175 http://www.ncbi.nlm.nih.gov/pubmed/9454524
- 352 Currie CJ, Poole CD, Gale EA. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009; 52 (09) 1766-1777 http://www.ncbi.nlm.nih.gov/pubmed/19572116
- 353 Johnson JA, Bowker SL. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 2011; 54 (01) 25-31 http://www.ncbi.nlm.nih.gov/pubmed/20959956
- 354 Ruiter R, Visser LE, van Herk-Sukel MP et al. Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study. Diabetologia 2012; 55 (01) 51-62 http://www.ncbi.nlm.nih.gov/pubmed/21956710
- 355 Davey P, Grainger D, MacMillan J et al. Clinical outcomes with insulin lispro compared with human regular insulin: a meta-analysis. Clin Ther 1997; 19 (04) 656-674 http://www.ncbi.nlm.nih.gov/pubmed/9377611
- 356 Plank J, Siebenhofer A, Berghold A et al. Systematic review and meta-analysis of short-acting insulin analogues in patients with diabetes mellitus. Arch Intern Med 2005; 165 (12) 1337-1344 http://www.ncbi.nlm.nih.gov/pubmed/15983281
- 357 Siebenhofer A, Plank J, Berghold A et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Syst Rev 2006; (02) CD003287 http://www.ncbi.nlm.nih.gov/pubmed/16625575
- 358 Shukle VK, Otten N. Insulin lispro: a critical evaluation. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1999
- 359 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Kurzwirksame Insulinanaloga zur Behandlung des Diabetes mellitus Typ 2. Abschlussbericht. Auftrag A05–04. Version 1.0. 2005 [cited: 2013 Jul 04]. Available from: http://www.iqwig.de/download/A05-04_Abschlussbericht_Kurzwirksame_Insulinanaloga_bei_Typ_2_Diabetes_mellitus.pdf
- 360 Horvath K, Jeitler K, Berghold A et al. Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2007; (02) CD005613 http://www.ncbi.nlm.nih.gov/pubmed/17443605
- 361 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Langwirksame Insulinanaloga zur Behandlung des Diabetes mellitus Typ 2. Abschlussbericht. Auftrag A05–03. Version 1.1. 2009 [cited: 2013 Jul 04]. Available from: http://www.iqwig.de/download/A05-03_Abschlussbericht_Langwirksame_Insulinanaloga_bei_Diabetes_mellitus_Typ_2_V1.1.pdf
- 362 Monami M, Marchionni N, Mannucci E. Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract 2008; 81 (02) 184-189 http://www.ncbi.nlm.nih.gov/pubmed/18495286
- 363 Brunner GA, Hirschberger S, Sendlhofer G et al. Post-prandial administration of the insulin analogue insulin aspart in patients with Type 1 diabetes mellitus. Diabet Med 2000; 17 (05) 371-375 http://www.ncbi.nlm.nih.gov/pubmed/10872536
- 364 Rave K, Klein O, Frick AD et al. Advantage of premeal-injected insulin glulisine compared with regular human insulin in subjects with type 1 diabetes. Diabetes Care 2006; 29 (08) 1812-1817 http://www.ncbi.nlm.nih.gov/pubmed/16873785
- 365 DeWitt DE, Hirsch IB. Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. JAMA 2003; 289 (17) 2254-2264 http://www.ncbi.nlm.nih.gov/pubmed/12734137
- 366 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Kurzwirksame Insulinanaloga zur Behandlung des Diabetes mellitus Typ 1. Abschlussbericht. Auftrag A05–02. Version 1.0. 2007 [cited: 2013 Jul 04]. Available from https://www.iqwig.de/download/A05-02_Abschlussbericht_Kurzwirksame_Insulinanaloga_bei_Diabetes_mellitus_Typ_1.pdf
- 367 Müller N, Frank T, Kloos C et al. Randomized crossover study to examine the necessity of an injection-to-meal interval in patients with type 2 diabetes mellitus and human insulin. Diabetes Care 2013; http://www.ncbi.nlm.nih.gov/pubmed/23340895
- 368 Fritsche A, Larbig M, Owens D et al. Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study. Diabetes Obes Metab 2010; 12 (02) 115-123 http://www.ncbi.nlm.nih.gov/pubmed/20092584
- 369 Holman RR, Farmer AJ, Davies MJ et al. Three-Year Efficacy of Complex Insulin Regimens in Type 2 Diabetes. N Engl J Med 2009; 361 (18) 1736-1747 http://www.ncbi.nlm.nih.gov/pubmed/19850703
- 370 Deutsche Diabetes Gesellschaft (DDG). Matthaei S, Kellerer M. (eds.). Therapie des Typ-1-Diabetes. S3-Leitlinie. Version 1.0. 2011 [cited: 2013 Jul 04]. Available from: http://www.deutsche-diabetes-gesellschaft.de/redaktion/mitteilungen/leitlinien/AktualisierungTherapieTyp1Diabetes_1_20110929.pdf
- 371 Kinmonth AL, Baum JD. Timing of pre-breakfast insulin injection and postprandial metabolic control in diabetic children. Br Med J 1980; 280 (6214) 604-606 http://www.ncbi.nlm.nih.gov/pubmed/6989436
- 372 Witt MF, White NH, Santiago JV. Roles of site and timing of the morning insulin injection in type 1 diabetes. J Pediatr 1983; 103 (04) 528-533 http://www.ncbi.nlm.nih.gov/pubmed/6352884
- 373 Dimitriadis GD, Gerich JE. Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus. Diabetes Care 1983; 6 (04) 374-377 http://www.ncbi.nlm.nih.gov/pubmed/6352210
- 374 Lean ME, Ng LL, Tennison BR. Interval between insulin injection and eating in relation to blood glucose control in adult diabetics. Br Med J (Clin Res Ed) 1985; 290 (6462) 105-108 http://www.ncbi.nlm.nih.gov/pubmed/3917700
- 375 Scheen AJ, Letiexhe MR, Lefebvre PJ. Minimal influence of the time interval between injection of regular insulin and food intake on blood glucose control of type 1 diabetic patients on a basal-bolus insulin scheme. Diabetes Metab 1999; 25 (02) 157-162 http://www.ncbi.nlm.nih.gov/pubmed/10443327
- 376 Müller N, Frank T, Kloos C et al. Randomized 2-phases-crossover-study to examine the necessity of an injection-to-meal interval in patients with diabetes mellitus type 2 and flexible insulin therapy with human insulin. Diabetologia 2009; 52: 356
- 377 Blonde L. Current antihyperglycemic treatment guidelines and algorithms for patients with type 2 diabetes mellitus. Am J Med 2010; 123 (03) S12-S18 http://www.ncbi.nlm.nih.gov/pubmed/20206727
- 378 Mullan RJ, Montori VM, Shah ND et al. The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med 2009; 169 (17) 1560-1568 http://www.ncbi.nlm.nih.gov/pubmed/19786674
- 379 Bennett WL, Maruthur NM, Singh S et al. Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations. Ann Intern Med 2011; 154 (09) 602-613 http://www.ncbi.nlm.nih.gov/pubmed/21403054
- 380 Karagiannis T, Paschos P, Paletas K et al. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ 2012; 344: e1369 http://www.ncbi.nlm.nih.gov/pubmed/22411919
- 381 Lerch C, Richter B. Kombinationstherapie mit Insulin und oralen Antidiabetika. Z Allg Med 2010; 6-13
- 382 Fonseca V, Gill J, Zhou R et al. An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypoglycaemia. Diabetes Obes Metab 2011; 13 (09) 814-822 http://www.ncbi.nlm.nih.gov/pubmed/21481127
- 383 Blickle JF, Hancu N, Piletic M et al. Insulin glargine provides greater improvements in glycaemic control vs. intensifying lifestyle management for people with type 2 diabetes treated with OADs and 7-8% A1c levels. The TULIP study. Diabetes Obes Metab 2009; 11 (04) 379-386 http://www.ncbi.nlm.nih.gov/pubmed/19087105
- 384 Schiel R, Muller UA. Efficacy and treatment satisfaction of once-daily insulin glargine plus one or two oral antidiabetic agents versus continuing premixed human insulin in patients with type 2 diabetes previously on long-term conventional insulin therapy: the Switch pilot study. Exp Clin Endocrinol Diabetes 2007; 115 (10) 627-633 http://www.ncbi.nlm.nih.gov/pubmed/18058596
- 385 Gerstein HC, Yale JF, Harris SB et al. A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study. Diabet Med 2006; 23 (07) 736-774 http://www.ncbi.nlm.nih.gov/pubmed/16842477
- 386 Rosenstock J, Sugimoto D, Strange P et al. Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients. Diabetes Care 2006; 29 (03) 554-559 http://www.ncbi.nlm.nih.gov/pubmed/16505505
- 387 Janka HU, Plewe G, Riddle MC et al. Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes. Diabetes Care 2005; 28 (02) 254-259 http://www.ncbi.nlm.nih.gov/pubmed/15677775
- 388 Holman RR, Farmer AJ, Davies MJ et al. Erratum: Three-Year Efficacy of Complex Insulin Regimens in Type 2 Diabetes. N Engl J Med 2010; 363: 2078
- 389 Holman RR, Thorne KI, Farmer AJ et al. Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes. N Engl J Med 2007; 357 (17) 1716-1730 http://www.ncbi.nlm.nih.gov/pubmed/17890232
- 390 Douek IF, Allen SE, Ewings P et al. Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial. Diabet Med 2005; 22 (05) 634-640 http://www.ncbi.nlm.nih.gov/pubmed/15842521
- 391 Ponssen HH, Elte JW, Lehert P et al. Combined metformin and insulin therapy for patients with type 2 diabetes mellitus. Clin Ther 2000; 22 (06) 709-718 http://www.ncbi.nlm.nih.gov/pubmed/10929918
- 392 Fritsche A, Schmulling RM, Haring HU et al. Intensive insulin therapy combined with metformin in obese type 2 diabetic patients. Acta Diabetol 2000; 37 (01) 13-18 http://www.ncbi.nlm.nih.gov/pubmed/10928231
- 393 Morrow L, Hompesch M, Guthrie H et al. Co-administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction. Diabetes Obes Metab 2011; 13 (01) 75-80 http://www.ncbi.nlm.nih.gov/pubmed/21114606
- 394 Devries JH, Bain SC, Rodbard HW et al. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care 2012; 35 (07) 1446-1454 http://www.ncbi.nlm.nih.gov/pubmed/22584132
- 395 Buse JB, Bergenstal RM, Glass LC et al. Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med 2011; 154 (02) 103-112 http://www.ncbi.nlm.nih.gov/pubmed/21138825
- 396 Landstedt-Hallin L, Adamson U, Arner P et al. Comparison of bedtime NPH or preprandial regular insulin combined with glibenclamide in secondary sulfonylurea failure. Diabetes Care 1995; 18 (08) 1183-1186 http://www.ncbi.nlm.nih.gov/pubmed/7587856
- 397 Taskinen MR, Sane T, Helve E et al. Bedtime insulin for suppression of overnight free-fatty acid, blood glucose, and glucose production in NIDDM. Diabetes 1989; 38 (05) 580-588 http://www.ncbi.nlm.nih.gov/pubmed/2653929
- 398 Riddle MC. Evening insulin strategy. Diabetes Care 1990; 13 (06) 676-686 http://www.ncbi.nlm.nih.gov/pubmed/2192851
- 399 Riddle MC, Hart JS, Bouma DJ et al. Efficacy of bedtime NPH insulin with daytime sulfonylurea for subpopulation of type II diabetic subjects. Diabetes Care 1989; 12 (09) 623-629 http://www.ncbi.nlm.nih.gov/pubmed/2507265
- 400 Miller JL, Salman K, Shulman LH et al. Bedtime insulin added to daytime sulfonylureas improves glycemic control in uncontrolled type II diabetes. Clin Pharmacol Ther 1993; 53 (03) 380-384 http://www.ncbi.nlm.nih.gov/pubmed/8453858
- 401 Clauson P, Karlander S, Steen L et al. Daytime glibenclamide and bedtime NPH insulin compared to intensive insulin treatment in secondary sulphonylurea failure: a 1-year follow-up. Diabet Med 1996; 13 (05) 471-477 http://www.ncbi.nlm.nih.gov/pubmed/8737030
- 402 Chow CC, Tsang LW, Sorensen JP et al. Comparison of insulin with or without continuation of oral hypoglycemic agents in the treatment of secondary failure in NIDDM patients. Diabetes Care 1995; 18 (03) 307-314 http://www.ncbi.nlm.nih.gov/pubmed/7555472
- 403 Yki-Jarvinen H, Dressler A, Ziemen M. Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group. Diabetes Care 2000; 23 (08) 1130-1136 http://www.ncbi.nlm.nih.gov/pubmed/10937510.
- 404 Puhakainen I, Taskinen MR, Yki-Jarvinen H. Comparison of acute daytime and nocturnal insulinization on diurnal glucose homeostasis in NIDDM. Diabetes Care 1994; 17 (08) 805-809 http://www.ncbi.nlm.nih.gov/pubmed/7956622
- 405 Soneru IL, Agrawal L, Murphy JC et al. Comparison of morning or bedtime insulin with and without glyburide in secondary sulfonylurea failure. Diabetes Care 1993; 16 (06) 896-901 http://www.ncbi.nlm.nih.gov/pubmed/8325203
- 406 Groop LC, Widen E, Ekstrand A et al. Morning or bedtime NPH insulin combined with sulfonylurea in treatment of NIDDM. Diabetes Care 1992; 15 (07) 831-834 http://www.ncbi.nlm.nih.gov/pubmed/1516500
- 407 Yki-Jarvinen H, Kauppila M, Kujansuu E et al. Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1992; 327 (20) 1426-1433 http://www.ncbi.nlm.nih.gov/pubmed/1406860
- 408 Lotz N, Bachmann W. Kombinationstherapie. In: Mehnert H, Standl E, editors. Diabetologie in Klinik und Praxis. Stuttgart: Thieme; 1999: 212-218
- 409 Lebovitz HE, Pasmantier R. Combination insulin-sulfonylurea therapy. Diabetes Care 1990; 13 (06) 667-675 http://www.ncbi.nlm.nih.gov/pubmed/2192850
- 410 Bailey TS, Mezitis NH. Combination therapy with insulin and sulfonylureas for type II diabetes. Diabetes Care 1990; 13 (06) 687-695 http://www.ncbi.nlm.nih.gov/pubmed/2192852
- 411 Abraira C, Colwell JA, Nuttall FQ et al. Veterans Affairs Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Results of the feasibility trial. Veterans Affairs Cooperative Study in Type II Diabetes. Diabetes Care 1995; 18 (08) 1113-1123 http://www.ncbi.nlm.nih.gov/pubmed/7587846
- 412 Grant PJ. The effects of metformin on cardiovascular risk factors. Diabetes Metab Rev 1995; 11 (Suppl. 01) S43-S50 http://www.ncbi.nlm.nih.gov/pubmed/8529484
- 413 Campbell IW, Howlett HC. Worldwide experience of metformin as an effective glucose-lowering agent: a meta-analysis. Diabetes Metab Rev 1995; 11 (Suppl. 01) S57-S62 http://www.ncbi.nlm.nih.gov/pubmed/8529486
- 414 Hermann LS, Schersten B, Bitzen PO et al. Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations. A double-blind controlled study. Diabetes Care 1994; 17 (10) 1100-1109 http://www.ncbi.nlm.nih.gov/pubmed/7821128
- 415 UK Prospective Diabetes Study (UKPDS). UKPDS 28: a randomized trial of efficacy of early addition of metformin in sulfonylurea-treated type 2 diabetes. U. K. Prospective Diabetes Study Group. Diabetes Care 1998; 21 (01) 87-92 http://www.ncbi.nlm.nih.gov/pubmed/9538975
- 416 DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 1995; 333 (09) 541-549 http://www.ncbi.nlm.nih.gov/pubmed/7623902
- 417 Aschner P, Katzeff HL, Guo H et al. Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes. Diabetes Obes Metab 2010; 12 (03) 252-261 http://www.ncbi.nlm.nih.gov/pubmed/20070351
- 418 Reasner C, Olansky L, Seck TL et al. The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2011; 13 (07) 644-652 http://www.ncbi.nlm.nih.gov/pubmed/21410627
- 419 Seck TL, Engel SS, Williams-Herman DE et al. Sitagliptin more effectively achieves a composite endpoint for A1C reduction, lack of hypoglycemia and no body weight gain compared with glipizide. Diabetes Res Clin Pract 2011; 93 (01) e15-e17 http://www.ncbi.nlm.nih.gov/pubmed/21477878
- 420 Hirst JA, Farmer AJ, Ali R et al. Quantifying the effect of metformin treatment and dose on glycemic control. Diabetes Care 2012; 35 (02) 446-554 http://www.ncbi.nlm.nih.gov/pubmed/22275444
- 421 Donnelly LA, Doney AS, Hattersley AT et al. The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes. Diabet Med 2006; 23 (02) 128-133 http://www.ncbi.nlm.nih.gov/pubmed/16433709
- 422 Hemmingsen B, Christensen LL, Wetterslev J et al. Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ 2012; 344: e1771 http://www.ncbi.nlm.nih.gov/pubmed/22517929
- 423 Fisman EZ, Tenenbaum A, Boyko V et al. Oral antidiabetic treatment in patients with coronary disease: time-related increased mortality on combined glyburide/metformin therapy over a 7. 7-year follow-up. Clin Cardiol 2001; 24 (02) 151-158 http://www.ncbi.nlm.nih.gov/pubmed/11460818
- 424 Olsson J, Lindberg G, Gottsater M et al. Increased mortality in Type II diabetic patients using sulphonylurea and metformin in combination: a population-based observational study. Diabetologia 2000; 43 (05) 558-560 http://www.ncbi.nlm.nih.gov/pubmed/10855529
- 425 Gulliford M, Latinovic R. Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study. Diabetes Metab Res Rev 2004; 20 (03) 239-245 http://www.ncbi.nlm.nih.gov/pubmed/15133756
- 426 Kahler KH, Rajan M, Rhoads GG et al. Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration. Diabetes Care 2007; 30 (07) 1689-1693 http://www.ncbi.nlm.nih.gov/pubmed/17440170
- 427 Eurich DT, Majumdar SR, McAlister FA et al. Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diabetes Care 2005; 28 (10) 2345-2351 http://www.ncbi.nlm.nih.gov/pubmed/16186261
- 428 Johnson JA, Simpson SH, Toth EL et al. Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes. Diabet Med 2005; 22 (04) 497-502 http://www.ncbi.nlm.nih.gov/pubmed/15787679
- 429 Salpeter SR, Buckley NS, Ormiston TM et al. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006; 144 (12) 904-912 http://www.ncbi.nlm.nih.gov/pubmed/16754916
- 430 Salpeter SR, Greyber E, Pasternak GA et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2010; (01) CD002967 http://www.ncbi.nlm.nih.gov/pubmed/20091535
- 431 Groop L, Neugebauer C. Clinical pharmacology of sulfonylureas. In: Kuhlmann J, Puls W, editors. Oral antidiabetics. Handbook of experimental pharmacology. Berlin: Springer; 1996
- 432 Gonzalez-Ortiz M, Guerrero-Romero JF, Violante-Ortiz R et al. Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus. J Diabetes Complications 2009; 23 (06) 376-379 http://www.ncbi.nlm.nih.gov/pubmed/18849173
- 433 Garratt KN, Brady PA, Hassinger NL et al. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction. Journal of the American College of Cardiology 1999; 33 (01) 119-124 http://www.ncbi.nlm.nih.gov/pubmed/9935017
- 434 Scognamiglio R, Avogaro A, Vigili de Kreutzenberg S et al. Effects of treatment with sulfonylurea drugs or insulin on ischemia-induced myocardial dysfunction in type 2 diabetes. Diabetes 2002; 51 (03) 808-812 http://www.ncbi.nlm.nih.gov/pubmed/11872684
- 435 Jollis JG, Simpson Jr RJ, Cascio WE et al. Relation between sulfonylurea therapy, complications, and outcome for elderly patients with acute myocardial infarction. Am Heart J 1999; 138 (5 Pt 1): S376-S380 http://www.ncbi.nlm.nih.gov/pubmed/10539800
- 436 Huizar JF, Gonzalez LA, Alderman J et al. Sulfonylureas attenuate electrocardiographic ST-segment elevation during an acute myocardial infarction in diabetics. Journal of the American College of Cardiology 2003; 42 (06) 1017-1021 http://www.ncbi.nlm.nih.gov/pubmed/13678923
- 437 Khalangot M, Tronko M, Kravchenko V et al. Glibenclamide-related excess in total and cardiovascular mortality risks: data from large Ukrainian observational cohort study. Diabetes Res Clin Pract 2009; 86 (03) 247-253 http://www.ncbi.nlm.nih.gov/pubmed/19796836
- 438 Simpson SH, Majumdar SR, Tsuyuki RT et al. Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study. CMAJ 2006; 174 (02) 169-174 http://www.ncbi.nlm.nih.gov/pubmed/16415461
- 439 Siebenhofer A, Plank J, Berghold A et al. Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus. Cochrane Database Syst Rev 2006; (02) CD003287 http://www.ncbi.nlm.nih.gov/pubmed/16625575
- 440 European Medicines Agency (EMA). EPAR Insulin glusilin (Apidra) – Scientific discussion. London: EMA; 2005
- 441 European Medicines Agency (EMA). EPAR Insulin lispro (Humalog) – Scientific discussion. London: EMA; 2005
- 442 Hermansen K, Davies M, Derezinski T et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 2006; 29 (06) 1269-1274 http://www.ncbi.nlm.nih.gov/pubmed/16732007
- 443 Raslova K, Bogoev M, Raz I et al. Insulin detemir and insulin aspart: a promising basal-bolus regimen for type 2 diabetes. Diabetes Res Clin Pract 2004; 66 (02) 193-201 http://www.ncbi.nlm.nih.gov/pubmed/15533587
- 444 Haak T, Tiengo A, Draeger E et al. Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes. Diabetes Obes Metab 2005; 7 (01) 56-64 http://www.ncbi.nlm.nih.gov/pubmed/15642076
- 445 National Institute for Health and Clinical Excellence (NICE). The clinical effectiveness and cost effectiveness of long acting insulin analogues for diabetes. Technology appraisals TA 53. 2002 [cited: 2013 Aug 12]. Available from: http://guidance.nice.org.uk/TA53
- 446 European Medicines Agency (EMA). EPAR Insulin detemir – Scientific discussion. London: EMA; 2004
- 447 European Medicines Agency (EMA). EPAR Lantus. Internationaler Freinamen (INN). Insulin glargin – Scientific discussion. London: EMA; 2000
- 448 Giovannucci E, Harlan DM, Archer MC et al. Diabetes and cancer: a consensus report. Diabetes Care 2010; 33 (07) 1674-1685 http://www.ncbi.nlm.nih.gov/pubmed/20587728
- 449 Currie CJ, Poole CD, Jenkins-Jones S et al. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care 2012; 35 (02) 299-304 http://www.ncbi.nlm.nih.gov/pubmed/22266734
- 450 Mussig K, Staiger H, Kantartzis K et al. Type 2 diabetes mellitus and risk of malignancy: is there a strategy to identify a subphenotype of patients with increased susceptibility to endogenous and exogenous hyperinsulinism?. Diabet Med 2011; 28 (03) 276-286 http://www.ncbi.nlm.nih.gov/pubmed/21309835
- 451 Boyle P, Koechlin A, Boniol M et al. Updated meta-analysis of cancer risk among users of insulin glargine. Poster. Diabetes 2012; 61 (Suppl. 01) A345
- 452 Lebovitz H. Alpha-Glucosidase inhibitors as agents in the treatment of diabetes. Diabetes Rev 1998; 6: 132-145
- 453 Holman RR, Cull CA, Turner RC. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U. K. Prospective Diabetes Study 44). . Diabetes Care 1999; 22 (06) 960-964 http://www.ncbi.nlm.nih.gov/pubmed/10372249
- 454 Santeusanio F, Ventura MM, Contadini S. Efficacy and safety of two different dosages of acarbose in non-insulin dependent diabetic patients treated by diet alone. Diabetes Nutr Metab 2005; 6: 147-54
- 455 Hotta N, Kakuta H, Sano T et al. Long-term effect of acarbose on glycaemic control in non-insulin-dependent diabetes mellitus: a placebo-controlled double-blind study. Diabet Med 1993; 10 (02) 134-138 http://www.ncbi.nlm.nih.gov/pubmed/8458189
- 456 Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study. Am J Med 1997; 103 (06) 483-490 http://www.ncbi.nlm.nih.gov/pubmed/9428831
- 457 Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in NIDDM patients. The Essen Study. Diabetes Care 1994; 17 (06) 561-566 http://www.ncbi.nlm.nih.gov/pubmed/8082525
- 458 Hanefeld M, Fischer S, Schulze J et al. Therapeutic potentials of acarbose as first-line drug in NIDDM insufficiently treated with diet alone. Diabetes Care 1991; 14 (08) 732-737 http://www.ncbi.nlm.nih.gov/pubmed/1954810
- 459 Coniff RF, Shapiro JA, Robbins D et al. Reduction of glycosylated hemoglobin and postprandial hyperglycemia by acarbose in patients with NIDDM. A placebo-controlled dose-comparison study. Diabetes Care 1995; 18 (06) 817-824 http://www.ncbi.nlm.nih.gov/pubmed/7555508
- 460 Chiasson JL, Josse RG, Hunt JA et al. The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. A multicenter controlled clinical trial. Ann Intern Med 1994; 121 (12) 928-935 http://www.ncbi.nlm.nih.gov/pubmed/7734015
- 461 Braun D, Schönherr U, Mitzkat HJ. Efficacy of acarbose monotherapy in patients with type 2 diabetes: A double-blind study conducted in general practice. Endocrin Metabol 1996; 3: 275-280
- 462 Van de Laar FA, Lucassen PL, Akkermans RP et al. Alpha-glucosidase inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 2005; (02) CD003639 http://www.ncbi.nlm.nih.gov/pubmed/15846673
- 463 Hanefeld M, Cagatay M, Petrowitsch T et al. Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur Heart J 2004; 25 (01) 10-16 http://www.ncbi.nlm.nih.gov/pubmed/14683737
- 464 Chiasson JL, Josse RG, Gomis R et al. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 2002; 359 (9323) 2072-2077 http://www.ncbi.nlm.nih.gov/pubmed/12086760
- 465 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Hinweise auf Störungen der Leberfunktion unter Acarbose-Anwendung. Dtsch Arztebl 1992; 89: A1649
- 466 Johnston PS, Lebovitz HE, Coniff RF et al. Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. J Clin Endocrinol Metab 1998; 83 (05) 1515-1522 http://www.ncbi.nlm.nih.gov/pubmed/9589648
- 467 Johnston PS, Coniff RF, Hoogwerf BJ et al. Effects of the carbohydrase inhibitor miglitol in sulfonylurea-treated NIDDM patients. Diabetes Care 1994; 17 (01) 20-29 http://www.ncbi.nlm.nih.gov/pubmed/8112185
- 468 AstraZeneca. Onglyza 2,5 mg/5 mg Filmtabletten. Zusammenfassung der Merkmale des Arzneimittels. Fachinformation. Stand der Information: Dezember 2011. 2011 [cited: 2012 Aug 16]. Available from: http://www.fachinfo.de
- 469 Gemeinsamer Bundesausschuss (G-BA). Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL): Anlage XII – Beschlüsse über die Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a des Fünften Buches Sozialgesetzbuch (SGB V). Linagliptin. 2012 [cited: 2013 Jul 04]. Available from: http://www.g-ba.de/downloads/39-261-1472/2012-03-29_AM-RL-XII_Linagliptin_BAnz.pdf
- 470 European Medicines Agency (EMA). Assessment report. Trajenta linagliptin. Procedure No.: EMEA/H/C/002110/0000. 2011 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002110/WC500115748.pdf
- 471 Gemeinsamer Bundesausschuss (G-BA). Beschluss des Gemeinsamen Bundesausschusses über die Einleitung eines Stellungnahmeverfahrens zur Änderung der Arzneimittel-Richtlinie (AM-RL) in Anlage IV: Therapiehinweis zu Gliptinen bzw. DPP-4 Inhibitoren. 2010 [cited: 2013 Jul 04]. Available from: http://www.g-ba.de/downloads/39-261-1270/2010-12-07-AM-RL4-SN-Gliptine.pdf
- 472 European Medicines Agency (EMA). CHMP Assessment Report for Onglyza. International Nonproprietary Name: saxagliptin. Procedure No. EMEA/H/C/001039. 2009 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001039/WC500044319.pdf
- 473 Gemeinsamer Bundesausschuss (G-BA). Beschluss des Gemeinsamen Bundesausschusses über die Einleitung eines Stellungnahmeverfahrens zur Änderung der Arzneimittel-Richtlinie in Anlage 4: Therapiehinweis zu Vildagliptin. 2008 [cited: 2013 Jul 04]. Available from: http://www.g-ba.de/downloads/39-261-720/2008-08-21-AMR4-SN-Vildagliptin.pdf
- 474 Gemeinsamer Bundesausschuss (G-BA). Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie in Anlage 4: Therapiehinweis zu Sitagliptin. 2008 [cited: 2013 Jul 04]. Available from: http://www.g-ba.de/downloads/39-261-655/2008-04-10-AMR4-Sitagliptin_BAnz.pdf
- 475 European Medicines Agency (EMA). Januvia 25 mg film-coated tablets. 2011 [cited: 2013 Jul 04]. Available from: http://www.emea.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000722/WC500039054.pdf
- 476 European Medical Agency (EMA). Galvus: EPAR – Scientific Discussion. 2007 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000771/WC500020330.pdf
- 477 Richter B, Bandeira-Echtler E, Bergerhoff K et al. Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008; (02) CD006739 http://www.ncbi.nlm.nih.gov/pubmed/18425967
- 478 European Medicines Agency (EMA). EPAR Sitagliptin (Januvia) – Scientific discussion. 2007 [cited: 2013 Aug 12]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000722/WC500039057.pdf
- 479 Monami M, Iacomelli I, Marchionni N et al. Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 2010; 20 (04) 224-235 http://www.ncbi.nlm.nih.gov/pubmed/19515542
- 480 Henness S, Keam SJ. Vildagliptin. Drugs 2006; 66 (15) 1989-2001 http://www.ncbi.nlm.nih.gov/pubmed/17100408
- 481 Charbonnel B, Karasik A, Liu J et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006; 29 (12) 2638-2643 http://www.ncbi.nlm.nih.gov/pubmed/17130197
- 482 Rosenstock J, Kim SW, Baron MA et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2007; 9 (02) 175-185 http://www.ncbi.nlm.nih.gov/pubmed/17300593
- 483 Garber AJ, Schweizer A, Baron MA et al. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab 2007; 9 (02) 166-174 http://www.ncbi.nlm.nih.gov/pubmed/17300592
- 484 Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 2007; 298 (02) 194-206 http://www.ncbi.nlm.nih.gov/pubmed/17622601
- 485 Raz I, Hanefeld M, Xu L et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 2006; 49 (11) 2564-2571 http://www.ncbi.nlm.nih.gov/pubmed/17001471
- 486 Aschner P, Kipnes MS, Lunceford JK et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006; 29 (12) 2632-2637 http://www.ncbi.nlm.nih.gov/pubmed/17130196
- 487 Pratley RE, Jauffret-Kamel S, Galbreath E et al. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 2006; 38 (06) 423-428 http://www.ncbi.nlm.nih.gov/pubmed/16823726
- 488 Pi-Sunyer FX, Schweizer A, Mills D et al. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 2007; 76 (01) 132-138 http://www.ncbi.nlm.nih.gov/pubmed/17223217
- 489 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Informationsbrief zu schwerwiegenden Überempfindlichkeitsreaktionen und akuter Pankreatitis in Zusammenhang mit Saxagliptin (Onglyza®). 2012 [cited: 2013 Jun 26]. Available from: http://www.akdae.de/Arzneimittelsicherheit/DSM/Archiv/2012-198.html
- 490 Monami M, Dicembrini I, Antenore A et al. Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials. Diabetes Care 2011; 34 (11) 2474-2476 http://www.ncbi.nlm.nih.gov/pubmed/22025784
- 491 Novartis Pharma GmbH. Galvus® 50mg Tabletten, Vildagliptin. Fachinformation, Stand Oktober 2012. 2012 [cited: 2013 Jul 03]. Available from: http://www.fachinfo.de
- 492 AstraZeneca, Bristol-Myers Squibb. Onglyza® 2,5 mg/5 mg Filmtabletten, Saxagliptin. Fachinformation, Stand Februar 2013. 2013 [cited: 2013 Jul 03]. Available from: http://www.fachinfo.de
- 493 MSD Sharp und Dohme. Januvia®, Sitagliptin. Fachinformation, Stand Dezember 2012. 2012 [cited: 2013 Jul 04]. Available from: http://www.fachinfo.de
- 494 European Medical Agency (EMA). Trajenta: EPAR – Product Information. 2012 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002110/WC500115745.pdf
- 495 Nathan DM. Finding new treatments for diabetes – how many, how fast… how good?. N Engl J Med 2007; 356 (05) 437-440 http://www.ncbi.nlm.nih.gov/pubmed/17267901
- 496 Matthews DR, Dejager S, Ahren B et al. Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study. Diabetes Obes Metab 2010; 12 (09) 780-789 http://www.ncbi.nlm.nih.gov/pubmed/20649630
- 497 European Medical Agency (EMA). Komboglyze: EPAR – Summary for the public. 2011 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/de_DE/document_library/EPAR_-_Product_Information/human/002059/WC500119388.pdf
- 498 Holman RR, Haffner SM, McMurray JJ et al. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med 2010; 362 (16) 1463-1476 http://www.ncbi.nlm.nih.gov/pubmed/20228402
- 499 Fuhlendorff J, Rorsman P, Kofod H et al. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes 1998; 47 (03) 345-351 http://www.ncbi.nlm.nih.gov/pubmed/9519738
- 500 Owens DR, Luzio SD, Ismail I et al. Increased prandial insulin secretion after administration of a single preprandial oral dose of repaglinide in patients with type 2 diabetes. Diabetes Care 2000; 23 (04) 518-523 http://www.ncbi.nlm.nih.gov/pubmed/10857945
- 501 Whitelaw DC, Clark PM, Smith JM et al. Effects of the new oral hypoglycaemic agent nateglinide on insulin secretion in Type 2 diabetes mellitus. Diabet Med 2000; 17 (03) 225-229 http://www.ncbi.nlm.nih.gov/pubmed/10784228
- 502 Horton ES, Clinkingbeard C, Gatlin M et al. Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes. Diabetes Care 2000; 23 (11) 1660-1665 http://www.ncbi.nlm.nih.gov/pubmed/11092289
- 503 Hirschberg Y, Karara AH, Pietri AO et al. Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin. Diabetes Care 2000; 23 (03) 349-353 http://www.ncbi.nlm.nih.gov/pubmed/10868864
- 504 Moses R, Slobodniuk R, Boyages S et al. Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 1999; 22 (01) 119-124 http://www.ncbi.nlm.nih.gov/pubmed/10333912
- 505 Massi-Benedetti M, Damsbo P. Pharmacology and clinical experience with repaglinide. Expert Opin Investig Drugs 2000; 9 (04) 885-898 http://www.ncbi.nlm.nih.gov/pubmed/11060717
- 506 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Glinide zur Behandlung des Diabetes mellitus Typ 2. Abschlussbericht A05–05C. Version 1.0. 2009 [cited: 2013 Jul11]. Available from: https://www.iqwig.de/download/A05-05C_Kurzfassung_Abschlussbericht_Glinide_zur_Behandlung_des_Diabetes_mellitus_Typ_2.pdf
- 507 Goldberg RB, Einhorn D, Lucas CP et al. A randomized placebo-controlled trial of repaglinide in the treatment of type 2 diabetes. Diabetes Care 1998; 21 (11) 1897-1903 http://www.ncbi.nlm.nih.gov/pubmed/9802740
- 508 Landgraf R, Bilo HJG. Repaglinide vs glibenclamide: a 14-week efficacy and safety comparison. Diabetologia 1997; 40: A321
- 509 Wolffenbuttel BH, Landgraf R. A 1-year multicenter randomized double-blind comparison of repaglinide and glyburide for the treatment of type 2 diabetes. Dutch and German Repaglinide Study Group. Diabetes Care 1999; 22 (03) 463-467 http://www.ncbi.nlm.nih.gov/pubmed/10097930
- 510 McLeod JF. Clinical pharmacokinetics of nateglinide: a rapidly-absorbed, short-acting insulinotropic agent. Clin Pharmacokinet 2004; 43 (02) 97-120 http://www.ncbi.nlm.nih.gov/pubmed/14748619
- 511 Marbury T, Huang WC, Strange P et al. Repaglinide versus glyburide: a one-year comparison trial. Diabetes Res Clin Pract 1999; 43 (03) 155-166 http://www.ncbi.nlm.nih.gov/pubmed/10369424
- 512 Rosenstock J, Hassman DR, Madder RD et al. Repaglinide versus nateglinide monotherapy: a randomized, multicenter study. Diabetes Care 2004; 27 (06) 1265-1270 http://www.ncbi.nlm.nih.gov/pubmed/15161773
- 513 Grossman SL, Lessem J. Mechanisms and clinical effects of thiazolidinediones. Expert Opin Investig Drugs 1997; 6 (08) 1025-1040 http://www.ncbi.nlm.nih.gov/pubmed/15989661
- 514 Day C. Thiazolidinediones: a new class of antidiabetic drugs. Diabet Med 1999; 16 (03) 179-192 http://www.ncbi.nlm.nih.gov/pubmed/10227562
- 515 Ghazzi MN, Perez JE, Antonucci TK et al. Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group. Diabetes 1997; 46 (03) 433-439 http://www.ncbi.nlm.nih.gov/pubmed/9032099
- 516 Hanefeld M, Göke B. Combining pioglitazone with sulfonylurea or metformin in the management of type 2 diabetes. Exp Clin Endocrinol Diabetes 2000; 108: S256-S266
- 517 Fonseca V, Rosenstock J, Patwardhan R et al. Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. JAMA 2000; 283 (13) 1695-1702 http://www.ncbi.nlm.nih.gov/pubmed/10755495
- 518 Dormandy JA, Charbonnel B, Eckland DJ et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005; 366 (9493) 1279-1289 http://www.ncbi.nlm.nih.gov/pubmed/16214598
- 519 Erdmann E, Dormandy JA, Charbonnel B et al. The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study. J Am Coll Cardiol 2007; 49 (17) 1772-1780 http://www.ncbi.nlm.nih.gov/pubmed/17466227
- 520 Chiquette E, Ramirez G, Defronzo R. A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors. Arch Intern Med 2004; 164 (19) 2097-2104 http://www.ncbi.nlm.nih.gov/pubmed/15505122
- 521 Nesto RW, Bell D, Bonow RO et al. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Circulation 2003; 108 (23) 2941-2948 http://www.ncbi.nlm.nih.gov/pubmed/14662691.
- 522 Gerstein HC, Yusuf S, Bosch J et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 2006; 368 (9541) 1096-1105 http://www.ncbi.nlm.nih.gov/pubmed/16997664
- 523 Singh S, Loke YK, Furberg CD. Thiazolidinediones and heart failure: a teleo-analysis. Diabetes Care 2007; 30 (08) 2148-2153 http://www.ncbi.nlm.nih.gov/pubmed/17536074
- 524 Home PD, Pocock SJ, Beck-Nielsen H et al. Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis. N Engl J Med 2007; 357 (01) 28-38 http://www.ncbi.nlm.nih.gov/pubmed/17551159
- 525 Thomas ML, Lloyd SJ. Pulmonary edema associated with rosiglitazone and troglitazone. Ann Pharmacother 2001; 35 (01) 123-124 http://www.ncbi.nlm.nih.gov/pubmed/11197573
- 526 Grey A, Bolland M, Gamble G et al. The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab 2007; 92 (04) 1305-1310 http://www.ncbi.nlm.nih.gov/pubmed/17264176
- 527 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Takeda Pharma GmbH: Wichtige Sicherheitsinformation zu Frakturen unter Pioglitazon-Einnahme. Rote-Hand-Brief vom 28. März 2007. 2007 [cited: 2013 Jul 04]. Available from: http://www.akdae.de/Arzneimittelsicherheit/RHB/Archiv/2007/54-20070402.pdf
- 528 Wolfe SM, Lurie P, Barbehenn E. Citizen's petition to immediately require class labeling for the diabetes drugs troglitazone (Rezulin), rosiglitazone (Avandia) and pioglitazone (Actos). 2000 [cited: 2013 Jul 04]. Available from: http://www.citizen.org/documents/1514.pdf
- 529 Hoeft S, Vogel A, Kellerer M. Multiorganversagen mit Lactatazidose unter Metformin und Glitazontherapie. Diabetologie Stoffwechsel 2006; 1: 151-154
- 530 Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Tödliches Leberversagen unter Pioglitazon. UAW-News – International. 2006 [cited: 2013 Jul 04]. Available from: http://www.akdae.de/Arzneimittelsicherheit/Bekanntgaben/Archiv/2006/771_200603311.pdf
- 531 Chase MP, Yarze JC. Pioglitazone-associated fulminant hepatic failure. Am J Gastroenterol 2002; 97 (02) 502-503 http://www.ncbi.nlm.nih.gov/pubmed/11866308
- 532 May LD, Lefkowitch JH, Kram MT et al. Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy. Ann Intern Med 2002; 136 (06) 449-452 http://www.ncbi.nlm.nih.gov/pubmed/11900497
- 533 Maeda K. Hepatocellular injury in a patient receiving pioglitazone. Ann Intern Med 2001; 135 (04) 306 http://www.ncbi.nlm.nih.gov/pubmed/11511159
- 534 Freid J, Everitt D, Boscia J. Rosiglitazone and hepatic failure. Ann Intern Med 2000; 132 (02) 164 http://www.ncbi.nlm.nih.gov/pubmed/10644281
- 535 Al-Salman J, Arjomand H, Kemp DG et al. Hepatocellular injury in a patient receiving rosiglitazone. A case report. Ann Intern Med 2000; 132 (02) 121-124 http://www.ncbi.nlm.nih.gov/pubmed/10644273
- 536 Forman LM, Simmons DA, Diamond RH. Hepatic failure in a patient taking rosiglitazone. Ann Intern Med 2000; 132 (02) 118-121 http://www.ncbi.nlm.nih.gov/pubmed/10644272
- 537 Elkinson S, Keating GM. Lixisenatide: first global approval. Drugs 2013; 73 (04) 383-391 http://www.ncbi.nlm.nih.gov/pubmed/23558600
- 538 Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132 (06) 2131-2157 http://www.ncbi.nlm.nih.gov/pubmed/17498508
- 539 Ussher JR, Drucker DJ. Cardiovascular biology of the incretin system. Endocr Rev 2012; 33 (02) 187-215 http://www.ncbi.nlm.nih.gov/pubmed/22323472
- 540 Vilsboll T, Christensen M, Junker AE et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012; 344: d7771 http://www.ncbi.nlm.nih.gov/pubmed/22236411
- 541 Henry RR, Buse JB, Sesti G et al. Efficacy of antihyperglycemic therapies and the influence of baseline hemoglobin A(1C): a meta-analysis of the liraglutide development program. Endocr Pract 2011; 17 (06) 906-913 http://www.ncbi.nlm.nih.gov/pubmed/22193143
- 542 European Medical Agency (EMA). Byetta: EPAR Product Information. 2012 [cited: 2013 Jul 04]. Available from: http://www.ema.europa.eu/docs/de_DE/document_library/EPAR_-_Product_Information/human/000698/WC500051845.pdf
- 543 Lilly. Bydureon 2 mg Pulver und Lösungsmittel zur Herstellung einer Depot-Injektionssuspension. Fachinformation. Stand der Information: Juni 2011. 2011 [cited: 2012 Aug 15]. Available from: http://www.fachinfo.de
- 544 Riddle MC, Henry RR, Poon TH et al. Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin. Diabetes Metab Res Rev 2006; 22 (06) 483-491 http://www.ncbi.nlm.nih.gov/pubmed/16634116
- 545 Kendall DM, Riddle MC, Rosenstock J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005; 28 (05) 1083-1091 http://www.ncbi.nlm.nih.gov/pubmed/15855571
- 546 DeFronzo RA, Ratner RE, Han J et al. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005; 28 (05) 1092-1100 http://www.ncbi.nlm.nih.gov/pubmed/15855572
- 547 Buse JB, Henry RR, Han J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004; 27 (11) 2628-2635 http://www.ncbi.nlm.nih.gov/pubmed/15504997
- 548 Jendle J, Nauck MA, Matthews DR et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab 2009; 11 (12) 1163-1172 http://www.ncbi.nlm.nih.gov/pubmed/19930006
- 549 Garber A, Henry R, Ratner R et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009; 373 (9662) 473-481 http://www.ncbi.nlm.nih.gov/pubmed/18819705
- 550 Drucker DJ, Buse JB, Taylor K et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008; 372 (9645) 1240-1250 http://www.ncbi.nlm.nih.gov/pubmed/18782641
- 551 Bergenstal RM, Wysham C, Macconell L et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010; 376 (9739) 431-439 http://www.ncbi.nlm.nih.gov/pubmed/20580422
- 552 Diamant M, Van Gaal L, Stranks S et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet 2010; 375 (9733) 2234-2243 http://www.ncbi.nlm.nih.gov/pubmed/20609969
- 553 Christensen M, Knop FK, Vilsboll T et al. Lixisenatide for type 2 diabetes mellitus. Expert Opin Investig Drugs 2011; 20 (04) 549-557 http://www.ncbi.nlm.nih.gov/pubmed/21391833
- 554 U. S. Food and Drug Administration (FDA). Exenatide (marked as Byetta). FDA Alert 10/2007. Silver Spring: FDA; 2007
- 555 European Medicines Agency (EMA). Victoza liraglutide. EPAR summary for the public. EMEA/H/C/1026. 2009 [cited: 2013 Jul 04]. Available from: http://www.emea.europa.eu/docs/en_GB/document_library/EPAR_-_Summary_for_the_public/human/001026/WC500050013.pdf
- 556 Food and Drug Administration (FDA). Victoza (liraglutide [rDNA origin]) Injection: REMS – Risk of Thyroid C-cell Tumors, Acute Pancreatitis. 2011 [cited: 2013 Jul 04]. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm258826.htm
- 557 Novo Nordisk Inc. Victoza® (liraglutide [rDNA origin] injection). 2011 [cited: 2012 Jul 18]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022341s004lbl.pdf?utm_campaign=Google2&utm_source=fdaSearch&utm_medium=website&utm_term=victoza&utm_content=7
- 558 Joffe H, Parks M. FDA Briefing Materials. Liraglutide. Background Memorandum. 2009 [cited: 2013 Jul 04]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM148645.pdf
- 559 Parola A. FDA Briefing Materials. Liraglutide. Pharmacology/Toxicology Review of Thyroid c-cell Tumors in Rats and Mice. 2009 [cited: 2013 Jul 04]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM148645.pdf
- 560 Parola T. Victoza (Iiraglutide injection): Human Relevance of Rodent Thyroid C-cell Tumors. Novo Nordisk A/S. NDA 22-341. FDA. Center for Drug Evaluation and Research. Endocrinologic and Metabolic Drugs Advisory Committee Meeting, 2. April 2009. 2009 [cited: 2013 Jul 04]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM151129.pdf
- 561 Mahoney KM, Derr J. Victoza® (liraglutide injection): Major Adverse Cardiovascular Events, Thyroid Cancer, and Calcitonin. Novo Nordisk: New Drug Application 22 22-341. 2009 [cited: 2013 Jul 04]. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM151147.pdf
- 562 Nauck MA. A Critical Analysis of the Clinical Use of Incretin-Based Therapies: The benefits by far outweigh the potential risks. Diabetes Care 2013; 36 (07) 2126-2132 http://www.ncbi.nlm.nih.gov/pubmed/23645884
- 563 Butler PC, Elashoff M, Elashoff R et al. A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe?. Diabetes Care 2013; 36 (07) 2118-2125 http://www.ncbi.nlm.nih.gov/pubmed/23645885
- 564 Gallwitz B, Guzman J, Dotta F et al. Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial. Lancet 2012; 379 (9833) 2270-2278 http://www.ncbi.nlm.nih.gov/pubmed/22683137
- 565 Kassenärztliche Bundesvereinigung (KBV), Arzneimittelkommission der deutschen Ärzteschaft (AkdÄ). Exenatide (Byetta). Wirkstoff aktuell. 2007 [cited: 2013 Aug 12]. Available from: http://daris.kbv.de/daris/link.asp?ID=1003753714
- 566 Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). Bewertung des therapeutischen Nutzens von Exenatide. Rapid Report. Auftrag A05–23. Version 1.0. 2007 [cited: 2013 Aug 12]. Available from: http://www.iqwig.de/download/A05-23_Rapid_Report_Bewertun_des_therapeutischen_Nutzen_von_Exenatide.pdf
- 567 Gemeinsamer Bundesausschuss. Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie in Anlage 4: Therapiehinweis zu Exenatide Vom 19. Juni 2008/16. Oktober 2008. 2008 [cited: 2013 Aug 12]. Available from: http://www.g-ba.de/downloads/39-261-736/2008-10-16-AMR4-Exenatide_BAnz.pdf
- 568 Skaliodas S, Hatzikostas H, Lamropoulou N. Comparative clinical study of homeopathic and allopathic treatment in diabetes mellitus type II. In: Proceedings of the 43rd Congress of the International Homoeopathic Medical League. Athens: May 22-26 1988: 549-56
- 569 Deng R. A review of the hypoglycemic effects of five commonly used herbal food supplements. Recent Pat Food Nutr Agric 2012; 4 (01) 50-60 http://www.ncbi.nlm.nih.gov/pubmed/22329631
- 570 Ammon HPT. Zimt bei Typ-2-Diabetes: diabetisches Nahrungsmittel oder Arzneimittel. Diabetologie Stoffwechsel 2008; 3 (05) 296-300
- 571 Khan A, Safdar M, li Khan MM et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003; 26 (12) 3215-3218 http://www.ncbi.nlm.nih.gov/pubmed/14633804
- 572 Mang B, Wolters M, Schmitt B et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 2006; 36 (05) 340-344 http://www.ncbi.nlm.nih.gov/pubmed/16634838
- 573 Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009; 22 (05) 507-512 http://www.ncbi.nlm.nih.gov/pubmed/19734396
- 574 Vanschoonbeek K, Thomassen BJ, Senden JM et al. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 2006; 136 (04) 977-980 http://www.ncbi.nlm.nih.gov/pubmed/16549460
- 575 Schopman JE, Geddes J, Frier BM. Prevalence of impaired awareness of hypoglycaemia and frequency of hypoglycaemia in insulin-treated type 2 diabetes. Diabetes Res Clin Pract 2010; 87 (01) 64-68 http://www.ncbi.nlm.nih.gov/pubmed/19939489
- 576 Frier BM. How hypoglycaemia can affect the life of a person with diabetes. Diabetes Metab Res Rev 2008; 24 (02) 87-92 http://www.ncbi.nlm.nih.gov/pubmed/18088077
- 577 Graveling AJ, Frier BM. Hypoglycaemia: an overview. Prim Care Diabetes 2009; 3 (03) 131-139 http://www.ncbi.nlm.nih.gov/pubmed/19782016
- 578 Schopman JE, Geddes J, Frier BM. Prevalence of impaired awareness of hypoglycaemia and frequency of hypoglycaemia in insulin-treated type 2 diabetes. Diabetes Res Clin Pract 2010; 87 (01) 64-68 http://www.ncbi.nlm.nih.gov/pubmed/19939489
- 579 Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet 2009; 373 (9677) 1798-1807 http://www.ncbi.nlm.nih.gov/pubmed/19465235
- 580 Moghissi ES, Korytkowski MT, DiNardo M et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009; 32 (06) 1119-1131 http://www.ncbi.nlm.nih.gov/pubmed/19429873
- 581 Kansagara D, Fu R, Freeman M et al. Intensive insulin therapy in hospitalized patients: a systematic review. Ann Intern Med 2011; 154 (04) 268-282 http://www.ncbi.nlm.nih.gov/pubmed/21320942
- 582 Qaseem A, Humphrey LL, Chou R et al. Use of intensive insulin therapy for the management of glycemic control in hospitalized patients: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2011; 154 (04) 260-267 http://www.ncbi.nlm.nih.gov/pubmed/21320941
- 583 Dhatariya K, Flanagan D, Hilton L et al. Management of adults with diabetes undergoing surgery and elective procedures: improving standards. 2011 [cited: 2013 Jul 04]. Available from http://www.diabetes.org.uk/Documents/Professionals/Reports%20and%20statistics/Management%20of%20adults%20with%20diabetes%20undergoing%20surgery%20and%20elective%20procedures%20-%20improving%20standards.pdf
- 584 Nyenwe EA, Kitabchi AE. Evidence-based management of hyperglycemic emergencies in diabetes mellitus. Diabetes Res Clin Pract 2011; 94 (03) 340-351 http://www.ncbi.nlm.nih.gov/pubmed/21978840
- 585 Rinnert K. Diabetes in der Arbeitswelt. Diabetologe 2012; (08) 167-175
- 586 Gräcmann N, Albrecht M. Bundesanstalt für Straßenwesen. Begutachtungs-Leitlinien zur Kraftfahrereignung. Bremerhaven: Wirtschaftsverlag NW; 2009 (Berichte der Bundesanstalt für Straßenwesen, Mensch und Sicherheit; M 115). Available from: http://www.bast.de/cln_033/nn_42640/SharedDocs/Publikationen/Begutachtungsleitlinien
- 587 Richtlinie 2009/113/EG der Kommission vom 25. August 2009 zur Änderung der Richtlinie 2006/126/EG des Europäischen Parlaments und des Rates über den Führerschein. 2009 [cited: 2013 Jun 04]. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:223:0031:0035:DE:PDF
- 588 Richtlinie 2006/126/EG des europäischen Parlaments und des Rates vom 20. Dezember 2006 über den Führerschein (Neufassung). 2006 [cited: 2013 Jun 04]. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:403:0018:0060:DE:PDF
- 589 Deutsche Diabetes Gesellschaft (DDG), Deutsche Gesellschaft für Geriatrie (DGG). Scherbaum WA, Kiess W. (eds.), et al. Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Alter. Evidenzbasierte Diabetes-Leitlinie der Deutschen Diabetes Gesellschaft (DDG) und der Deutschen Gesellschaft für Geriatrie (DGG). Diabetes Stoffwechsel 2004; 13: 31-56
- 590 Zeyfang A. Diabetes im Alter – Werden die Patienten überfordert?. Dtsch Med Wochenschr 2006; 131 (20) 1159-1162 http://www.ncbi.nlm.nih.gov/pubmed/16705538
- 591 Brown AF, Mangione CM, Saliba D et al. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc 2003; 51 (05) S265-S280 http://www.ncbi.nlm.nih.gov/pubmed/12694461
- 592 Zeyfang A, Braun A, Wernecke J. Diabetes mellitus im Alter – Teil 1. Diabetologe 2011; (07) 57-60
- 593 Zeyfang A, Braun A, Wernecke J. Diabetes mellitus im Alter – Teil 2. Diabetologe 2011; (07) 139-142
- 594 AOK Rheinland Hamburg, BKK Landesverband NRW, Innungskrankenkasse Nordrhein, Landwirtschaftliche Krankenkasse NRW, Knappschaft, BARMER Ersatzkasse, Deutsche Angestellten-Krankenkasse, Techniker Krankenkasse, KKH-Allianz, Gmünder ErsatzKasse (GEK), Hanseatische Krankenkasse (HEK), Hamburg Münchener Krankenkasse, Kassenärztliche Vereinigung Nordrhein (KVNO). Vertrag über ein strukturiertes Behandlungsprogramm (DMP) nach § 137f SGB V zur Verbesserung der Qualität der ambulanten Versorgung von Typ 2-Diabetikern. 2010 [cited: 2013 Jul 17]. Available from: http://www.kvno.de/downloads/vertraege/dmp_diab2_vertrag.pdf
- 595 Gemeinsamer Bundesausschuss (G-BA). Anforderungen an strukturierte Behandlungsprogramme für Patienten mit Diabetes mellitus Typ 2. 20. RSA-ÄndV vom 23. Juni 2009. 2009 [cited: 2011 Aug 04]. Available from: http://www.g-ba.de/downloads/62-492-353/2009-07-01-RSAV20.pdf
- 596 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Chronische Herzinsuffizienz. 2009 [cited: 2010 Aug 23]. Available from: http://www.versorgungsleitlinien.de/themen/herzinsuffizienz
- 597 BKK Bundesverband. Sozialversicherungsgesetze 2011. Kompaktausgabe. SGB IV, V, IX, XI und Verträge. Stand: 1. Januar 2011. Essen: CW Haarfeld; 2007
- 598 Gemeinsamer Bundesausschuss (G-BA). Anforderungen an strukturierte Behandlungsprogramme für Patienten mit Diabetes mellitus Typ 1. 20. RSA-ÄndV vom 23.06.2009. 2009 [cited: 2013 Aug 12]. Available from: http://www.g-ba.de/downloads/62-492-352/2009-07-01-RSAV20.pdf
- 599 Drabik A, Sawicki PT, Muller D et al. Die Methoden der Evaluation von Disease Management Programmen im Kontrollgruppendesign am Beispiel Diabetes mellitus – Eine systematische Übersicht. Gesundheitswesen 2012; http://www.ncbi.nlm.nih.gov/pubmed/22454226
- 600 Gerlach FM, Beyer M, Saal K et al. Neue Perspektiven in der allgemeinmedizinischen Versorgung chronisch Kranker – Wider die Dominanz des Dringlichen. Teil 2: Chronic Care-Modell und Case Management als Grundlagen einer zukunftsorientierten hausärztlichen Versorgung. Z Arztl Fortbild Qualitatssich 2006; 100 (05) 345-352 http://www.ncbi.nlm.nih.gov/pubmed/16955620
- 601 Gerlach FM, Beyer M, Muth C et al. Neue Perspektiven in der allgemeinmedizinischen Versorgung chronisch Kranker – Wider die Dominanz des Dringlichen. Teil 1: Chronische Erkrankungen als Herausforderung für die hausärztliche Versorgungspraxis. Z Arztl Fortbild Qualitatssich 2006; 100 (05) 335-343 http://www.ncbi.nlm.nih.gov/pubmed/16955619
- 602 Bundesärztekammer (BÄK). (Muster-) Berufsordnung für die deutschen Ärztinnen und Ärzte. Berlin: BÄK; 2006 [cited: 2012 Mär 13]. Available from: http://www.baek.de/page.asp?his=1.100.1143
- 603 Kapell A. EDV-gestützte Diabetes-Dokumentation. Dtsch Arztebl/PraxisComp 1999; (03) 8-10
- 604 Ärztliches Zentrum für Qualität in der Medizin (ÄZQ) (eds.) Kompendium Q-M-A. Qualitätsmanagement in der ambulanten Versorgung. Gramsch E, Hoppe JD, Jonitz G. 3rd ed. Köln: Dt. Ärzte-Verl; 2008
- 605 Bundesministerium für Gesundheit und soziale Sicherung (BMGS). Sozialgesetzbuch (SGB) Fünftes Buch (V) – Gesetzliche Krankenversicherung – (Artikel 1 des Gesetzes v. 20. Dezember 1988, BGBl. I S. 2477). 1988 [cited: 2012 Mrz 20]. Available from: http://bundesrecht.juris.de/sgb_5/index.html
- 606 Bundesministerium für Gesundheit und soziale Sicherung (BMGS). Sozialgesetzbuch (SGB) Neuntes Buch (IX) Rehabilitation und Teilhabe behinderter Menschen. Stand: Zuletzt geändert durch Art. 5 G v. 22.12.2008 I 2959. 2008 [cited: 2011 Nov 22]. Available from: http://bundesrecht.juris.de/sgb_9/index.html
- 607 AOK Bundesverband. Was sind Qualitätsindikatoren?. In: AOK Bundesverband, editor. Qualitätsindikatoren der AOK für Arztnetze. Bonn: 2002: 10-19
- 608 Ärztliches Zentrum für Qualität in der Medizin (ÄZQ). Manual Qualitätsindikatoren. Manual für Autoren. Berlin: ÄZQ; 2009 (äzq Schriftenreihe; 36). Available from: http://www.aezq.de/mdb/edocs/pdf/schriftenreihe/schriftenreihe36.pdf
- 609 Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). Nationale VersorgungsLeitlinie Chronische KHK. Langfassung. Version 1.13. 2006 Available from: http://www.khk.versorgungsleitlinien.de