Compartmentalization of cAMP Signaling in Adipogenesis, Lipogenesis, and Lipolysis

M. Rogne; K. Taskén

doi:10.1055/s-0034-1389955

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2014; 46(12): 833-840
DOI: 10.1055/s-0034-1389955

Review

Compartmentalization of cAMP Signaling in Adipogenesis, Lipogenesis, and Lipolysis

M. Rogne

¹Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway

²Biotechnology Centre, University of Oslo, Oslo, Norway

,

K. Taskén

¹Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway

²Biotechnology Centre, University of Oslo, Oslo, Norway

³K. G. Jebsen Centre Inflammation Research Centre, University of Oslo, Oslo, Norway

⁴K. G. Jebsen Centre for Cancer Immunotherapy, University of Oslo, Oslo, Norway

⁵Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway

› Institutsangaben

Abstract

Energy storage and release at times of food excess or fasting are carefully coordinated processes that depend on the appropriate differentiation of mesenchymal stem cells into mature adipocytes (adipogenesis) forming white adipose tissue (WAT) and on regulatory signals for storage (lipogenesis) or mobilization (lipolysis) of triacylglycerides (TAGs) from lipid droplets. It is widely recognized that cAMP signaling via protein kinase A (PKA) is important both in adipogenesis and for hormonal control and lipolysis in WAT. A kinase anchoring proteins (AKAPs) target PKA to distinct subcellular compartments in close proximity to its specific substrates thereby providing spatial and temporal specificity in the mediation of biological effects controlled by the cAMP-PKA pathway. This review will provide an updated overview of some of the sites of regulation by cAMP in adipogenesis and lipolysis and the involvement of AKAPs and highlighting, as a recent example, the AKAP Optical Atrophy 1 (OPA1) and its role in the phosphorylation of Perilipin to induce lipolysis.

Key words

fat cell - adipose tissue - stem cells

Volltext

Referenzen

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