Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000126.xml
Intensivmedizin up2date 2015; 11(03): 229-244
DOI: 10.1055/s-0034-1392638
DOI: 10.1055/s-0034-1392638
Internistische Intensivmedizin
Akute Nierenschädigung
Further Information
Publication History
Publication Date:
29 July 2015 (online)
-
Bereits leichtgradige Nierenfunktionseinbußen gehen mit einer erhöhten Morbidität und Mortalität einher.
-
Frühzeitig sollte man eine nephrologische Konsultation anberaumen.
-
Urinmikroskopie und Sonografie sind wesentlich Elemente der nephrologischen Diagnostik.
-
Biomarker haben derzeit allenfalls einen begrenzten klinischen Nutzen.
-
Frühzeitige hämodynamische Optimierung mit chloridarmen, bilanzierten Vollelektrolytlösungen
-
Bei unzureichender Besserung und Anurie ist eine restriktive Volumentherapie vorteilhaft.
-
Katecholamin der Wahl ist nach derzeitigem Kenntnisstand Noradrenalin.
-
Überwachung der verordneten Nierenersatztherapie und der potenziellen Komplikationen.
-
Literatur
- 1 Chertow GM, Burdick E, Honour M et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16: 3365-3370
- 2 Fliser D, Laville M, Covic A et al. A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guidelines on acute kidney injury: part 1: definitions, conservative management and contrast-induced nephropathy. Nephrol Dial Transplant 2012; 27: 4263-4272
- 3 Jorres A, John S, Lewington A et al. A European Renal Best Practice (ERBP) position statement on the Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guidelines on Acute Kidney Injury: part 2: renal replacement therapy. Nephrol Dial Transplant 2013; 28: 2940-2945
- 4 Zarbock A, Kümpers P. Nierenersatztherapie bei kritisch kranken Patienten mit akuter Nierenschädigung. Intensivmedizin up2date 2014; 10: 105-116
- 5 Kielstein JT, Fliser D. Diagnose, Prävention und Therapie des akuten Nierenversagens. Intensivmedizin up2date 2007; 4: 173-188
- 6 Khwaja A. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl 2012; 2 (Suppl. 01) 8
- 7 Joannidis M, Metnitz PG. Epidemiology and natural history of acute renal failure in the ICU. Crit Care Clin 2005; 21: 239-249
- 8 Wald R, McArthur E, Adhikari NK et al. Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study. Am J Kidney Dis 2015; 65: 870-877
- 9 Ihra GC, Lehberger J, Hochrieser H et al. Development of demographics and outcome of very old critically ill patients admitted to intensive care units. Intensive Care Med 2012; 38: 620-626
- 10 Hickson LJ, Chaudhary S, Williams AW et al. Predictors of outpatient kidney function recovery among patients who initiate hemodialysis in the hospital. Am J Kidney Dis 2015; 65: 592-602
- 11 Kane-Gill SL, Sileanu FE, Murugan R et al. Risk factors for acute kidney injury in older adults with critical illness: a retrospective cohort study. Am J Kidney Dis 2015; 65: 860-869
- 12 Koulouridis I, Price LL, Madias NE et al. Hospital-acquired acute kidney injury and hospital readmission: a cohort study. Am J Kidney Dis 2015; 65: 275-282
- 13 Kirwan CJ, Blunden MJ, Dobbie H et al. Critically ill patients requiring acute renal replacement therapy are at an increased risk of long-term renal dysfunction, but rarely receive specialist nephrology follow-up. Nephron 2015; 129: 164-170
- 14 Harel Z, Wald R, Bargman JM et al. Nephrologist follow-up improves all-cause mortality of severe acute kidney injury survivors. Kidney Int 2013; 83: 901-908
- 15 Kellum JA, Bellomo R, Ronco C. The concept of acute kidney injury and the RIFLE criteria. Contrib Nephrol 2007; 156: 10-16
- 16 Mehta RL, Kellum JA, Shah SV et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31
- 17 Palevsky PM, Liu KD, Brophy PD et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 2013; 61: 649-672
- 18 Prowle JR, Liu YL, Licari E et al. Oliguria as predictive biomarker of acute kidney injury in critically ill patients. Crit Care 2011; 15: R172
- 19 Thomas ME, Blaine C, Dawnay A et al. The definition of acute kidney injury and its use in practice. Kidney Int 2015; 87: 62-73
- 20 Thomas ME, Sitch A, Baharani J et al. Earlier intervention for acute kidney injury: evaluation of an outreach service and a long-term follow-up. Nephrol Dial Transplant 2015; 30: 239-244
- 21 Wilson FP, Shashaty M, Testani J et al. Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 2015; 385: 1966-1974
- 22 Ali T, Tachibana A, Khan I et al. The changing pattern of referral in acute kidney injury. QJM 2011; 104: 497-503
- 23 Balasubramanian G, Al-Aly Z, Moiz A et al. Early nephrologist involvement in hospital-acquired acute kidney injury: a pilot study. Am J Kidney Dis 2011; 57: 228-234
- 24 Mehta RL, McDonald B, Gabbai F et al. Nephrology consultation in acute renal failure: does timing matter?. Am J Med 2002; 113: 456-461
- 25 Joannidis M, Druml W, Forni LG et al. Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the Working Group for Nephrology, ESICM. Intensive Care Med 2010; 36: 392-411
- 26 Hafer C, Kielstein JT. Akutes Nierenversagen. Nephrologe 2011; 6: 120-127
- 27 Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet 2005; 365: 417-430
- 28 Levey AS, Becker C, Inker LA. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA 2015; 313: 837-846
- 29 Coca SG, Garg AX, Swaminathan M et al. Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery. Nephrol Dial Transplant 2013; 28: 2787-2799
- 30 Vandenberghe W, De Corte W, Hoste EA. Contrast-associated AKI in the critically ill: relevant or irrelevant?. Curr Opin Crit Care 2014; 20: 596-605
- 31 McDonald RJ, McDonald JS, Carter RE et al. Intravenous contrast material exposure is not an independent risk factor for dialysis or mortality. Radiology 2014; 273: 714-725
- 32 Cely CM, Schein RM, Quartin AA. Risk of contrast induced nephropathy in the critically ill: a prospective, case matched study. Crit Care 2012; 16: R67
- 33 Brunsveld-Reinders AH, Arbous MS, Kuiper SG et al. A comprehensive method to develop a checklist to increase safety of intra-hospital transport of critically ill patients. Crit Care 2015; 19: 214
- 34 Kooiman J, Sijpkens YW, de Vries JP et al. A randomized comparison of 1-h sodium bicarbonate hydration versus standard peri-procedural saline hydration in patients with chronic kidney disease undergoing intravenous contrast-enhanced computerized tomography. Nephrol Dial Transplant 2014; 29: 1029-1036
- 35 Monnet X, Rienzo M, Osman D et al. Passive leg raising predicts fluid responsiveness in the critically ill. Crit Care Med 2006; 34: 1402-1407
- 36 Thiel SW, Kollef MH, Isakow W. Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study. Crit Care 2009; 13: R111
- 37 Pons B, Lautrette A, Oziel J et al. Diagnostic accuracy of early urinary index changes in differentiating transient from persistent acute kidney injury in critically ill patients: multicenter cohort study. Crit Care 2013; 17: R56
- 38 Wlodzimirow KA, Abu-Hanna A, Royakkers AA et al. Transient versus persistent acute kidney injury and the diagnostic performance of fractional excretion of urea in critically ill patients. Nephron Clin Pract 2014; 126: 8-13
- 39 Perazella MA, Coca SG, Hall IE et al. Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients. Clin J Am Soc Nephrol 2010; 5: 402-408
- 40 Koyner JL, Davison DL, Brasha-Mitchell E et al. Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity. J Am Soc Nephrol 2015; Feb 5. pii: ASN.2014060535 [Epub ahead of print] PMID: 25655065
- 41 Schmidt JJ, Kielstein JT. Three shades of fluids: Bergstrom 2.0/Furosemide stress test/replacement fluid for therapeutic plasma exchange. Dtsch Med Wochenschr 2015; 140: 897-899
- 42 Chawla LS. The furosemide stress test to predict renal function after continuous renal replacement therapy. Authorsʼ response. Crit Care 2014; 18: 429
- 43 Chawla LS, Davison DL, Brasha-Mitchell E et al. Development and standardization of a furosemide stress test to predict the severity of acute kidney injury. Crit Care 2013; 17: R207
- 44 van der Voort PH, Boerma EC, Pickkers P. The furosemide stress test to predict renal function after continuous renal replacement therapy. Crit Care 2014; 18: 429
- 45 Mehta RL, Pascual MT, Soroko S et al. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 2002; 288: 2547-2553
- 46 Cantarovich F, Rangoonwala B, Lorenz H et al. High-dose furosemide for established ARF: a prospective, randomized, double-blind, placebo-controlled, multicenter trial. Am J Kidney Dis 2004; 44: 402-409
- 47 van der Voort PH, Boerma EC, Koopmans M et al. Furosemide does not improve renal recovery after hemofiltration for acute renal failure in critically ill patients: a double blind randomized controlled trial. Crit Care Med 2009; 37: 533-538
- 48 Hafer C, Becker T, Kielstein JT et al. High-dose erythropoietin has no effect on short- or long-term graft function following deceased donor kidney transplantation. Kidney Int 2012; 81: 314-320
- 49 Endre ZH, Walker RJ, Pickering JW et al. Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int 2010; 77: 1020-1030
- 50 Jacob KA, Leaf DE, Dieleman JM et al. Intraoperative High-Dose Dexamethasone and Severe AKI after Cardiac Surgery. J Am Soc Nephrol 2015; May 7. pii: ASN.2014080840 [Epub ahead of print] PMID: 25952257
- 51 Dieleman JM, Nierich AP, Rosseel PM et al. Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA 2012; 308: 1761-1767
- 52 Scrascia G, Guida P, Rotunno C et al. Anti-inflammatory strategies to reduce acute kidney injury in cardiac surgery patients: a meta-analysis of randomized controlled trials. Artif Organs 2014; 38: 101-112
- 53 Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368-1377
- 54 Mouncey PR, Osborn TM, Power GS et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015; 372: 1301-1311
- 55 Yealy DM, Kellum JA, Huang DT et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370: 1683-1693
- 56 Peake SL, Delaney A, Bailey M et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014; 371: 1496-1506
- 57 Levy MM. Early goal-directed therapy: what do we do now?. Crit Care 2014; 18: 705
- 58 Dellinger RP, Levy MM, Rhodes A et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580-637
- 59 Asfar P, Meziani F, Hamel JF et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med 2014; 370: 1583-1593
- 60 Lobo DN. Intravenous 0.9% saline and general surgical patients: a problem, not a solution. Ann Surg 2012; 255: 830-832
- 61 Yunos NM, Bellomo R, Hegarty C et al. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012; 308: 1566-1572
- 62 Shaw AD, Bagshaw SM, Goldstein SL et al. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 2012; 255: 821-829
- 63 Chen H, Wu B, Gong D et al. Fluid overload at start of continuous renal replacement therapy is associated with poorer clinical condition and outcome: a prospective observational study on the combined use of bioimpedance vector analysis and serum N-terminal pro-B-type natriuretic peptide measurement. Crit Care 2015; 19: 135
- 64 Serpa NetoA, Veelo DP, Peireira VG et al. Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review and meta-analysis of the literature. J Crit Care 2014; 29: 185.e1-7 DOI: 10.1016/j.jcrc.2013.09.031.
- 65 Brunkhorst FM, Engel C, Bloos F et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125-139
- 66 DGAI. S3-Leitlinie „Intravasale Volumentherapie beim Erwachsenen“ (Kurzversion). Anästhesiologie & Intensivmedizin 2014; 55 AWMF-Register-Nr.: 001/020
- 67 Gordon AC, Russell JA, Walley KR et al. The effects of vasopressin on acute kidney injury in septic shock. Intensive Care Med 2010; 36: 83-91
- 68 Russell JA, Walley KR, Singer J et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008; 358: 877-887
- 69 Cavallin M, Kamath PS, Merli M et al. Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial. Hepatology 2015; Jan 16. DOI: 10.1002/hep.27709. [Epub ahead of print] PMID: 25644760
- 70 Ellger B, Bösel J. SOP Hämodiafiltration. Intensivmedizin up2date 2015; 11: 4-8
- 71 John S. Renal replacement therapy as a possible trauma in acute kidney injury. Med Klin Intensivmed Notfmed 2014; 109: 342-347
- 72 Maynar Moliner J, Honore PM, Sanchez-Izquierdo Riera JA et al. Handling continuous renal replacement therapy-related adverse effects in intensive care unit patients: the dialytrauma concept. Blood Purif 2012; 34: 177-185
- 73 Vaara ST, Reinikainen M, Wald R et al. Timing of RRT based on the presence of conventional indications. Clin J Am Soc Nephrol 2014; 9: 1577-1585
- 74 Parienti JJ, Thirion M, Megarbane B et al. Femoral vs jugular venous catheterization and risk of nosocomial events in adults requiring acute renal replacement therapy: a randomized controlled trial. JAMA 2008; 299: 2413-2422
- 75 Dugue AE, Levesque SP, Fischer MO et al. Vascular access sites for acute renal replacement in intensive care units. Clin J Am Soc Nephrol 2012; 7: 70-77
- 76 Wang YT, Haines TP, Ritchie P et al. Early mobilization on continuous renal replacement therapy is safe and may improve filter life. Crit Care 2014; 18: R161
- 77 Schefold JC, Haehling S, Pschowski R et al. The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trial. Crit Care 2014; 18: R11
- 78 Kielstein JT, Lorenzen J, Kaever V et al. Risk of underdosing of ampicillin/sulbactam in patients with acute kidney injury undergoing extended daily dialysis – a single case. Nephrol Dial Transplant 2009; 24: 2283-2285
- 79 Kielstein JT, Burkhardt O. Dosing of antibiotics in critically ill patients undergoing renal replacement therapy. Curr Pharm Biotechnol 2011; 12: 2015-2019
- 80 Schmidt JJ, Hafer C, Spielmann J et al. Removal characteristics and total dialysate content of glutamine and other amino acids in critically ill patients with acute kidney injury undergoing extended dialysis. Nephron Clin Pract 2014; 126: 62-66
- 81 Meddings J, Saint S, Fowler KE et al. The Ann Arbor Criteria for Appropriate Urinary Catheter Use in Hospitalized Medical Patients: Results Obtained by Using the RAND/UCLA Appropriateness Method. Ann Intern Med 2015; 162: 1-34
- 82 Uchino S, Bellomo R, Morimatsu H et al. Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit Care Med 2009; 37: 2576-2582
- 83 Jones J, Holmen J, De Graauw J et al. Association of complete recovery from acute kidney injury with incident CKD stage 3 and all-cause mortality. Am J Kidney Dis 2012; 60: 402-408
- 84 Schiffl H, Lang SM, Fischer R. Long-term outcomes of survivors of ICU acute kidney injury requiring renal replacement therapy: a 10-year prospective cohort study. Clin Kidney J 2012; 5: 297-302
- 85 Schetz M, Gunst J, Van den Berghe G. The impact of using estimated GFR versus creatinine clearance on the evaluation of recovery from acute kidney injury in the ICU. Intensive Care Med 2014; 40: 1709-1717