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Semin Liver Dis 2014; 34(04): 465-468
DOI: 10.1055/s-0034-1394145
Diagnostic Problems in Hepatology
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Histological Changes in Nontumoral Liver Secondary to Radioembolization of Hepatocellular Carcinoma with Yttrium 90-impregnated Microspheres: Report of Two Cases

Sadhna Dhingra
1   Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center, Houston, Texas
,
Myron Schwartz
2   Recanati-Miller Transplantation Institute, Mount Sinai Health System, New York, New York
,
Edward Kim
3   Department of Vascular and Interventional Radiology, Mount Sinai Health System, New York, New York
,
Huaibin Mabel Ko
4   The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York
,
Stephen C. Ward
4   The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York
,
M. Isabel Fiel
4   The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York
,
Swan N. Thung
4   The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York
› Author Affiliations
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Publication History

Publication Date:
04 November 2014 (online)

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Abstract

Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.

Keywords

yttrium-90 - radioembolization - histology - nontumoral liver
 

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