Curcumin bei entzündlichen ­Erkrankungen

Zusammenfassung

Antiinflammatorische und antioxidative Wirkungen von Curcumin, dem Hauptwirkstoff der Gelbwurz (Curcuma longa L.) sind in zahlreichen Studien gut belegt. Die klinische Wirksamkeit wird erst in den letzten Jahren intensiver erforscht. Aufgrund der schlechten Bioverfügbarkeit wurden die Studien teilweise mit sehr hohen oralen Dosen bis 12 g pro Tag durchgeführt. Eine Erleichterung stellen resorptionsfördernde galenische Zubereitungen dar. Erst kürzlich wurde über eine vielversprechende Formulierung mit in Mizellen eingeschlossenem gelöstem Curcumin berichtet.

Abstract

Numerous pharmacological studies have demonstrated manifold anti-inflammatory and anti-oxidative activities of curcumin, the main active component in turmeric (Curcuma longa L.). Clinical efficacy however has been investigated more intensively in the most recent years. Bioavailability of curcumin is poor, and some investigations used high amounts of up to 12 g per day. Formulations improving bioavailability may solve this problem. A new formulation with curcumin in liquid micelles is promising.

Schlüsselwörter

Curcuma - Curcumin - Bioverfügbarkeit - Entzündung - klinische Wirksamkeit

Keywords

Curcuma - Curcumin - Bioavailability - Inflammation - clinical Efficacy

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