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Horm Metab Res 2015; 47(03): 165-167
DOI: 10.1055/s-0034-1398559
Hypothesis
© Georg Thieme Verlag KG Stuttgart · New York

Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?

E. Lau
1   Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João (CHSJ), Faculty of Medicine, University of Porto, Porto, Portugal
,
P. Freitas
1   Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João (CHSJ), Faculty of Medicine, University of Porto, Porto, Portugal
,
J. Costa
2   Department of Pathology, (CHSJ), Faculty of Medicine, University of Porto, Porto, Portugal
,
R. Batista
3   Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Faculty of Medicine, University of Porto, Porto, Portugal
,
V. Máximo
3   Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Faculty of Medicine, University of Porto, Porto, Portugal
4   Department of Pathology and Oncology, Faculty of Medicine, University of Porto, Porto, Portugal
,
R. Coelho
3   Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Faculty of Medicine, University of Porto, Porto, Portugal
,
L. Matos-Lima
5   Department of General Surgery, CHSJ, Faculty of Medicine, University of Porto, Porto, Portugal
,
C. Eloy
2   Department of Pathology, (CHSJ), Faculty of Medicine, University of Porto, Porto, Portugal
3   Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Faculty of Medicine, University of Porto, Porto, Portugal
,
D. Carvalho
1   Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João (CHSJ), Faculty of Medicine, University of Porto, Porto, Portugal
› Author Affiliations
Further Information

Publication History

received 02 July 2014

accepted 18 December 2014

Publication Date:
13 February 2015 (online)

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Abstract

Diffuse lipomatosis of the thyroid gland is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue, usually not accompanied by amyloid fibrils deposition. The pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a clinical case of a diffuse thyroid lipomatosis, whose immunohistochemical study of succinate dehydrogenase – subunit B (SDHB) revealed loss of expression of this protein in the follicular or adipose cells. We detected the presence of a recently described SDHB gene large deletion. Loss of mitochondrial SDHB expression may have a key role in understanding the pathophysiology of thyrolipomatosis, by regulating status of lipid metabolism.

Key words

lipomatosis - mitochondrial dysfunction - adipocyte
 

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