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Am J Perinatol 2015; 32(06): 591-598
DOI: 10.1055/s-0035-1544947
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Relation between Birth Weight and Weight and Height at the Age of 2 in Children Born Preterm

Gayle Olson
1   Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas
,
Steven J. Weiner
2   Department of Obstetrics and Gynecology, The George Washington University Biostatistics Center, Washington, District of Columbia
,
Dwight J. Rouse
3   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama
,
Uma M. Reddy
4   The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland
,
Brian M. Mercer
5   Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio
6   Department of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee
,
Michael W. Varner
7   Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah
,
Kenneth J. Leveno
8   Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas
,
Jay D. Iams
9   Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio
,
Ronald J. Wapner
10   Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania
11   Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania
,
Susan M. Ramin
12   Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas
,
Fergal D. Malone
13   Department of Obstetrics and Gynecology, Columbia University, New York, New York
,
Marshall W. Carpenter
14   Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island
,
Mary J. O'Sullivan
15   Department of Obstetrics and Gynecology, University of Miami, Miami, Florida
,
Mara J. Dinsmoor
16   Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, Illinois
,
Gary D. V. Hankins
1   Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, Texas
,
Steve N. Caritis
17   Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
,
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network › Author Affiliations
Further Information

Publication History

26 September 2014

19 December 2014

Publication Date:
02 March 2015 (online)

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Abstract

Objective The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight.

Study Design This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile.

Results Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: −0.66 [−1.58, −0.01] vs. −0.23 [−1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: −0.56 [−1.29, 0.19] vs. −0.24 [−0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R 2 = 0.04 and 0.02, respectively).

Conclusion Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.

Keywords

preterm - fetal growth potential - customized birth weight

Note

This article was presented at the Annual Meeting of the Society for Gynecologic Investigation March 16–19, 2011, Palm Beach, FL.


 

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