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Zeitschrift für Orthomolekulare Medizin 2015; 2(03): 11-15
DOI: 10.1055/s-0035-1547578
wissen
Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Evolutionsbiologische Erklärung der Alzheimerentstehung − Mikronährstoffe in Prävention und Therapie

Michael Nehls
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Publication History

Publication Date:
16 October 2015 (online)

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Zusammenfassung

Chronischer Stress, Mangel an Mikronährstoffen, fehlende Bewegung und andere Faktoren der Lebensweise lösen eine Kausalkette aus. Diese beginnt mit einer gestörten hippocampalen Neurogenese, die zunächst zu einem erhöhten Stresshormonlevel führt, dann zu Depressionen und letztendlich zu den für Alzheimer typischen neuropathologischen und kognitiven Veränderungen. Durch Beheben der Mängel lässt sich Alzheimer vermeiden und im Frühstadium der Erkrankung sogar therapieren.

Schlüsselwörter

Alzheimerdemenz - β-Amyloidstoffwechsel - adulte Neurogenese - Hippocampus - Stress - Minimumgesetz - Mikronährstoffe
 

  • Literatur

  • 1 James BD et al. Contribution of Alzheimer disease to mortality in the United States. Neurology 2014; 82: 1045-1050
    CrossrefGoogle Scholar
  • 2 Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease. Mol Neurodegener 2014; 1750-1326 DOI: 10.1186/-9-48.
    Google Scholar
  • 3 Nelson PT et al. Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies. Acta Neuropathol 2011; 121: 571-587
    CrossrefGoogle Scholar
  • 4 Lahdenperä M. Fitness benefits of prolonged post reproductive lifespan in women. Nature 2004; 428: 178-181
    CrossrefGoogle Scholar
  • 5 Brent JN. Ecological knowledge, leadership, and the evolution of menopause in Killer Whales. Current Biology 2015; 25: 746-750
    CrossrefGoogle Scholar
  • 6 Gurven M, Kaplan H. Longevity among hunter-gatherers: A cross-cultural examination. Population and Development Review 2007; 33: 321-365
    CrossrefGoogle Scholar
  • 7 Spalding KL et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 2013; 153: 1219-1227
    CrossrefGoogle Scholar
  • 8 Nehls M. Die Alzheimer-Lüge − Die Wahrheit über eine vermeidbare Krankheit. München: Heyne; 2014
    Google Scholar
  • 9 Du X, Pang TY. Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?. Front Psychiatry 2015; DOI: 10.3389/fpsyt.2015.00032. eCollection 2015
    Google Scholar
  • 10 Dranovsky A, Leonardo ED. Is there a role for young hippocampal neurons in adaptation to stress?. Behav Brain Res 2012; 227: 371-375
    CrossrefGoogle Scholar
  • 11 Nehls M. Alzheimer ist heilbar − Rechtzeitig zurück in ein gesundes Leben. München: Heyne; 2015
    Google Scholar
  • 12 Walker LC et al. Mechanisms of protein seeding in neurodegenerative diseases. JAMA Neurology 2013; 70: 304-310
    CrossrefGoogle Scholar
  • 13 Stöhr J et al. Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions. PNAS USA 2012; 109: 11025-11030
    CrossrefGoogle Scholar
  • 14 Cardoso BR et al. Importance and management of micronutrient deficiencies in patients with Alzheimer’s disease. Clin Interv Aging 2013; 8: 531-542
    Google Scholar
  • 15 Szewczyk B et al. The role of zinc in neurodegenerative inflammatory pathways in depression. Prog Neuropsy-chopharmacol Biol Psychiatry 2011; 35: 693-701
    CrossrefGoogle Scholar
  • 16 Conner TS et al. Optimal serum selenium concentrations are associated with lower depressive symptoms and negative mood among young adults. J Nutr 2015; 145: 59-65
    CrossrefGoogle Scholar
  • 17 Zhu Y et al. Abnormal neurogenesis in the dentate gyrus of adult mice lacking 1,25-dihydroxy vitamin D3 (1,25-(OH)2 D3). Hippocampus 2012; 22: 421-433
    CrossrefGoogle Scholar
  • 18 Littlejohns TJ et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014; 83: 920-928
    CrossrefGoogle Scholar
  • 19 Smith AD et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One; 2010. www.ncbi.nlm.nih.gov/pubmed/20838622
    Google Scholar
  • 20 Shin JY et al. Elevated homocysteine by levodopa is detrimental to neurogenesis in parkinsonian model. PLoS One; 2012. www.ncbi.nlm.nih.gov/pubmed/23209759
    Google Scholar
  • 21 Fiorentini A et al. Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice. PLoS One; 2010. www.ncbi.nlm.nih.gov/pubmed/21187954
    Google Scholar
  • 22 Ishii N et al. Low risk of male suicide and lithium in drinking water. J Clin Psychiatry 2015; 76: 319-326
    Google Scholar
  • 23 Terao T. Is lithium potentially a trace element?. World J Psychiatry 2015; 5: 1-3
    Google Scholar
  • 24 Nunes MA et al. Micro-dose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease. Curr Alzheimer Res 2013; 10: 104-107
    Google Scholar