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Int J Sports Med 2015; 36(12): 955-959
DOI: 10.1055/s-0035-1548886
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

BDNF, IGF-I, Glucose and Insulin during Continuous and Interval Exercise in Type 1 Diabetes

C. Tonoli
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
2   University of Lille; URePSSS, Physical Activity, Muscle Health Research Team, Lille, France
,
E. Heyman
2   University of Lille; URePSSS, Physical Activity, Muscle Health Research Team, Lille, France
,
B. Roelands
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
,
L. Buyse
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
,
F. Piacentini
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
3   Department of Movement, Human and Health Sciences, University of Rome, Rome, Italy
,
S. Berthoin
2   University of Lille; URePSSS, Physical Activity, Muscle Health Research Team, Lille, France
,
S. Bailey
4   Department of Physical Therapy Education, Elon University, Elon, United States
,
N. Pattyn
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
,
R. Meeusen
1   Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel, Brussels, Belgium
5   School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Queensland, Australia
› Author Affiliations
Further Information

Publication History



accepted after revision 06 March 2015

Publication Date:
24 July 2015 (online)

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Abstract

Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO2 max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health in T1D, but both types of exercise can be implemented.

Key word

diabetes - physical activity - neurotrophins - cognitive function - cognition
 

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