BDNF, IGF-I, Glucose and Insulin during Continuous and Interval Exercise in Type 1 Diabetes

Abstract

Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO₂ max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health in T1D, but both types of exercise can be implemented.

Key word

diabetes - physical activity - neurotrophins - cognitive function - cognition

• References

• 1 Abbott MA, Wells DG, Fallon JR. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 1999; 19: 7300-7308
• 2 Astrand PO, Rodahl K, Dahl HA, Stromme SB. Textbook of Work Physiology-4th: Physiological Bases of Exercise. 4^th ed Human Kinetics; 2003
• 3 Carro E, Trejo JL, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 2001; 21: 5678-5684
• 4 Cassilhas RC, Lee KS, Fernandes J, Oliveira MGM, Tufik S, Meeusen R, de Mello MT. Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms. Neuroscience 2012; 202: 309-317
• 5 Copeland JL, Heggie L. IGF-I and IGFBP-3 during continuous and interval exercise. Int J Sports Med 2008; 29: 182-187
• 6 Dregan A, Gulliford MC. Leisure-time physical activity over the life course and cognitive functioning in late mid-adult years. Psychol Med 2013; 43: 2447-2458
• 7 Ferris LT, Williams JS, Shen C-L. The Effect of Acute Exercise on Serum Brain-Derived Neurotrophic Factor Levels and Cognitive Function. Med Sci Sports Exerc 2007; 39: 728-734
• 8 Ferris LT, Williams JS, Shen CL. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc 2007; 39: 728-734
• 9 Galassetti PR, Iwanaga K, Crisostomo M, Zaldivar FP, Larson J, Pescatello A. Inflammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls. Pediatr Diabetes 2006; 7: 16-24
• 10 Gatti R, De Palo EF, Antonelli G, Spinella P. IGF-I/IGFBP system: metabolism outline and physical exercise. J Endocrinol Invest 2012; 35: 699-707
• 11 Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume, high-intensity interval training in health and disease. J Physiol 2012; 590: 1077-1084
• 12 Griffin ÉW, Mullally S, Foley C, Warmington SA, O’Mara SM, Kelly ÁM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011; 104: 934-941
• 13 Harriss DJ, Atkinson G. Ethical standards in sport and exercise science research: 2014 update. Int J Sports Med 2013; 34: 1025-1028
• 14 Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 2008; 9: 58-65
• 15 Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor: A Systematic Review of Experimental Studies in Human Subjects. Sports Med 2010; 40: 765-801
• 16 Little JP, Gillen JB, Percival ME, Safdar A, Tarnopolsky MA, Punthakee Z, Jung ME, Gibala MJ. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol 2011; 111: 1554-1560
• 17 Nguyen UN, Mougin F, Simon-Rigaud ML, Rouillon JD, Marguet P, Regnard J. Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. Eur J Appl Physiol 1998; 78: 533-537
• 18 Rasmussen P, Brassard P, Adser H, Pedersen MV, Leick L, Hart E, Secher NH, Pedersen BK, Pilegaard H. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009; 94: 1062-1069
• 19 Schulz KH, Gold SM, Witte J, Bartsch K, Lang UE, Hellweg R, Reer R, Braumann KM, Heesen C. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. J Neurol Sci 2004; 225: 11-18
• 20 Schwarz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab 1996; 81: 3492-3497
• 21 Tonoli C, Heyman E, Buyse L, Roelands B, Piacentini F, Bailey S, Pattyn N, Berthoin S, Meeusen R. Neurotrophins and cognitive functions in T1D compared to healthy controls: effects of a high-intensity exercise. J Appl Physiol Nutr Metab 2014; [Submitted – in revision]
• 22 Tonoli C, Heyman E, Roelands B, Pattyn N, Buyse L, Piacentini MF, Berthoin S, Meeusen R. Type 1 Diabetes-Associated Cognitive Decline: A Meta-Analysis; an update of the current literature. J Diabetes 2014;
• 23 Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. J Neurosci 2004; 20: 2580-2590
• 24 Wahl P, Zinner C, Achtzehn S, Bloch W, Mester J. Effect of high- and low-intensity exercise and metabolic acidosis on levels of GH, IGF-I, IGFBP-3 and cortisol. Growth Horm IGF Res 2010; 20: 380-385