Association of Antegrade Pulmonary Artery Diastolic Velocity with Spontaneous Closure of the Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants

Dawn M. Weiss; Jeffrey R. Kaiser; Christopher Swearingen; Sadia Malik; Ritu Sachdeva

doi:10.1055/s-0035-1554795

American Journal of Perinatology, Table of Contents

Am J Perinatol 2015; 32(13): 1217-1224
DOI: 10.1055/s-0035-1554795

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Association of Antegrade Pulmonary Artery Diastolic Velocity with Spontaneous Closure of the Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants

Dawn M. Weiss

¹Division of Neonatology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas

,

Jeffrey R. Kaiser

²Division of Neonatology, Departments of Pediatrics and Obstetrics and Gynecology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas

,

Christopher Swearingen

³Division of Biostatistics, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas

,

Sadia Malik

⁴Division of Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas

,

Ritu Sachdeva

⁵Division of Pediatric Cardiology, Department of Pediatrics, Emory School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia

› Author Affiliations

Abstract

Objective This study aims to determine echocardiographic parameters associated with spontaneous patent ductus arteriosus (PDA) closure in extremely low-birth-weight (ELBW) infants.

Study Design Retrospective demographic review and analysis of echocardiograms from 189 ELBW infants with suspected and confirmed hemodynamically significant PDA identified on an initial echocardiogram was performed. Comparison of echocardiographic parameters was made between infants with spontaneous closure versus those who received treatment.

Results The mean birth weight (787 ± 142 vs. 724 ± 141 g, p = 0.04) and gestational age (27.4 ± 2.8 vs. 26.2 ± 1.6 weeks, p = 0.03) were higher in the spontaneous closure versus the treatment group. Antegrade pulmonary artery (PA) diastolic velocity was lower in infants with spontaneous PDA closure versus those who received treatment (0.15 ± 0.06 vs. 0.22 ± 0.12 m/s, p = 0.009).

Conclusion Heavier and more mature ELBW infants with a lower antegrade PA diastolic velocity were likely to have spontaneous closure of the PDA.

Keywords

extremely low-birth-weight infant - ductus arteriosus - echocardiography

Full Text

References

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