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Synthesis 2016; 48(04): 535-540
DOI: 10.1055/s-0035-1560965
DOI: 10.1055/s-0035-1560965
paper
Rapid Synthesis of Functionalized (1-Benzo[d]thiazol-2-ylimidazolidin-4-ylidene)acetates and (1-Thiazol-2-ylimidazolidin-4-ylidene)acetates via a Three-Component Reaction
Further Information
Publication History
Received: 24 July 2015
Accepted after revision: 23 October 2015
Publication Date:
11 January 2016 (online)
Abstract
A simple synthetic protocol was developed for the efficient synthesis of functionalized (1-benzo[d]thiazol-2-ylimidazolidin-4-ylidene)acetates via a three-component reaction among 2-aminobenzothiazole, α,β-unsaturated N-arylaldimines, and dialkyl acetylenedicarboxylates in anhydrous dichloromethane at room temperature. Additionally, the three-component reaction with 2-aminothiazole afforded the corresponding (1-thiazol-2-ylimidazolidin-4-ylidene)acetates.
Key words
heterocycles - imidazoles - electron-deficient alkynes - benzothiazoles - multicomponent reactionsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560965.
- Supporting Information
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