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Synthesis 2016; 48(03): 413-420
DOI: 10.1055/s-0035-1560973
DOI: 10.1055/s-0035-1560973
paper
Transition-Metal-Free Synthesis of Indolizines from Electron-Deficient Alkenes via One-Pot Reaction Using TEMPO as an Oxidant
Further Information
Publication History
Received: 10 September 2015
Accepted after revision: 30 October 2015
Publication Date:
19 November 2015 (online)
Abstract
A one-pot method for the synthesis of multisubstituted indolizines from α-halo carbonyl compounds, pyridines, and electron-deficient alkenes is reported. The oxidative dehydrogenation reaction takes place under transition-metal-free conditions using TEMPO as an oxidant. This protocol uses ready available starting materials in a convenient procedure under mild reaction conditions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560973.
- Supporting Information
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Selected recent reviews for transition-metal-free reactions:
Selected recent articles for the synthesis of indolizines:
Selected reviews for TEMPO as oxidant or catalyst for oxidation: