Catalytic α-Alkylation/Reduction of Ketones with Primary Alcohols To Furnish Secondary Alcohols

Helena Lundberg; Hans Adolfsson

doi:10.1055/s-0035-1561315

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(05): 644-652
DOI: 10.1055/s-0035-1561315

short review

Catalytic α-Alkylation/Reduction of Ketones with Primary Alcohols To Furnish Secondary Alcohols

Helena Lundberg*

The Department of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, 10691 Stockholm, Sweden eMail: helena.lundberg@su.se eMail: hans.adolfsson@su.se

,

Hans Adolfsson*

The Department of Organic Chemistry, Stockholm University, The Arrhenius Laboratory, 10691 Stockholm, Sweden eMail: helena.lundberg@su.se eMail: hans.adolfsson@su.se

› Institutsangaben

Abstract

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Abstract

The formation of secondary alcohol products via a tandem α-alkylation/transfer hydrogenation of ketones with primary alcohols is a little explored reaction with unrealized potential for green synthesis. This review covers the current literature in the field, including asymmetric versions of the reaction, and outlines future possibilities and challenges for the methodology.

1 Introduction

2 Formation of Racemic Alcohols

3 Formation of Enantiomerically Enriched Alcohols

4 Conclusions

Key words

α-alkylation - transfer hydrogenation - ketone - alcohol - catalysis - tandem process

Volltext

Referenzen

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