Recent Advances in Bromination of Aromatic and Heteroaromatic Compounds

Abstract

This review covers recent advances in C–H bromination of aromatic substrates. Transition-metal-catalyzed/-mediated reactions and transition-metal-free methods are discussed.

1 Introduction

2 Transition-Metal-Catalyzed Bromination

2.1 Palladium-Catalyzed Reactions

2.2 Rhodium-, Cobalt- and Ruthenium-Catalyzed Reactions

2.3 Copper-Mediated Reactions

2.4 Gold-Catalyzed Reactions

3 Transition-Metal-Free Bromination

3.1 Conventional Electrophilic Bromination

3.2 Oxidative Bromination

3.3 Bromination of Heterocyclic N-Oxides

4 Conclusions

Key words

bromination - bromoarene - C–H activation - transition-metal­ catalysis - electrophilic bromination - oxidative bromination

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