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Synthesis 2016; 48(11): 1719-1726
DOI: 10.1055/s-0035-1561584
DOI: 10.1055/s-0035-1561584
paper
Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands
Further Information
Publication History
Received: 22 December 2015
Accepted after revision: 24 February 2016
Publication Date:
17 March 2016 (online)
Abstract
A range of chiral quinazolinol ligands were efficiently synthesized and subsequently investigated for catalytic chiral induction in both the asymmetric phenylation of aryl aldehydes and the asymmetric epoxidation of chalcones. Encouragingly, high enantioselectivities (up to 95%) and yields (up to 98%) were achieved under the optimized reaction conditions.
Key words
quinazolines - quinazolinones - enantioselective arylations - Weitz–Scheffer epoxidation - α,β-unsaturated ketonesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561584.
- Supporting Information
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