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Synthesis 2016; 48(18): 3077-3086
DOI: 10.1055/s-0035-1561628
DOI: 10.1055/s-0035-1561628
paper
Synthesis of Fluorescent Amino Acids via Palladium-Catalyzed Allylic Alkylations
Further Information
Publication History
Received: 11 February 2016
Accepted after revision: 06 April 2016
Publication Date:
19 May 2016 (online)
Abstract
Coumarin-derived allylic carbonates are found to be suitable electrophiles for the synthesis of fluorescent amino acids via palladium-catalyzed allylic alkylation of chelated glycine enolates. The formation of regioisomers can be suppressed by proper choice of the allyl carbonate.
Supporting Information
- Supporting information for this article (copies of NMR spectra) is available online at http://dx.doi.org/10.1055/s-0035-1561628.
- Supporting Information
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