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Synthesis 2016; 48(21): 3743-3752
DOI: 10.1055/s-0035-1561657
DOI: 10.1055/s-0035-1561657
paper
An Efficient Synthesis of 1,3-Benzothiadiazin-4(3H)-one 2-Oxides: Novel Anthranilic Acid Derivatives
Further Information
Publication History
Received: 05 April 2016
Accepted after revision: 02 May 2016
Publication Date:
15 June 2016 (online)
Abstract
Derivatives of anthranilic acid exhibit a range of useful biological activities. Herein we describe an efficient synthetic route to 1,3-benzothiadiazin-4(3H)-one 2-oxides via copper-catalyzed N-arylation of sulfonimidamides followed by cyclization. Such 1,3-benzothiadiazin-4(3H)-one 2-oxides can be viewed as novel anthranilic acid derivatives.
Key words
1,3-benzothiadiazin-4(3H)-one 2-oxides - anthranilic acid - N-arylation - sulfur - cyclization - copper catalysisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561657.
- Supporting Information
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