Sonogashira-Like Coupling Reactions with Phosphine–Gold(I) Alkynyl Complexes

Mogens Brøndsted Nielsen

doi:10.1055/s-0035-1561664

Synthesis, Inhaltsverzeichnis

Synthesis 2016; 48(17): 2732-2738
DOI: 10.1055/s-0035-1561664

short review

Sonogashira-Like Coupling Reactions with Phosphine–Gold(I) Alkynyl Complexes

Mogens Brøndsted Nielsen*

Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark eMail: mbn@chem.ku.dk

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Abstract

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Abstract

Phosphine–gold(I) alkynyl complexes are stable compounds that can be subjected to palladium-catalyzed cross-coupling reactions. This article outlines the synthesis of such compounds and their ability to play the role as substrates in Sonogashira couplings is covered. This synthetic approach is particularly attractive when the related terminal alkynes are unstable.

1 Introduction

2 Phosphine–Gold(I) Alkynyl Complexes

3 Sonogashira-Like Couplings

4 Transmetalation Step – Mechanistic Insight

5 Acetylenic Scaffolding with Tetraethynylethene Derivatives

6 Conclusion

Key words

alkynes - arylation - catalysis - complexes - copper - coupling - palladium

Volltext

Referenzen

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