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Synthesis 2016; 48(20): 3597-3602
DOI: 10.1055/s-0035-1562431
DOI: 10.1055/s-0035-1562431
paper
Iron(III) Chloride/l-Proline as an Efficient Catalyst for the Synthesis of 3-Substituted 1,2,4-Oxadiazoles from Amidoximes and Triethyl Orthoformate
Further Information
Publication History
Received: 10 March 2016
Accepted after revision: 28 April 2016
Publication Date:
15 June 2016 (online)
Abstract
A general, facile, and efficient method is presented for the synthesis of 3-substituted 1,2,4-oxadiazoles from amidoximes and triethyl orthoformate. The procedure employs an iron(III) chloride/l-proline catalytic system and the 3-substituted 1,2,4-oxadiazole products are obtained in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562431.
- Supporting Information
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