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Synthesis 2016; 48(23): 4199-4206
DOI: 10.1055/s-0035-1562474
DOI: 10.1055/s-0035-1562474
paper
Facile Synthesis of Some Chlorinated and Heteroatom-Rich Monocyclic β-Lactams via the Staudinger Reaction of Acyclic S-Alkylisothioureas
Further Information
Publication History
Received: 29 May 2016
Accepted after revision: 11 June 2016
Publication Date:
15 August 2016 (online)
Abstract
The optimized preparation of a rare class of highly functionalized (chlorinated and heteroatom-rich) monocyclic β-lactams by the Staudinger reaction of reactive acyclic S-alkylisothioureas with dichloroketene is presented. The use of acyclic S-alkylisothioureas in the Staudinger β-lactam synthesis has been demonstrated for the first time. The present method is mild, economical and wide in scope.
Key words
monocyclic β-lactams - dichloroketene - acyclic S-alkylisothioureas - Staudinger reaction - chlorinated - heteroatom richSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562474.
- Supporting Information
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