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Synthesis 2016; 48(20): 3504-3508
DOI: 10.1055/s-0035-1562484
DOI: 10.1055/s-0035-1562484
psp
Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitroanthranilate
Further Information
Publication History
Received: 20 May 2016
Accepted after revision: 02 July 2016
Publication Date:
11 August 2016 (online)
Abstract
A novel method for the synthesis of anthranilate esters is described. The esterification reaction of nitro-substituted anthranilic acids was carried out under microwave irradiation. A range of solvents and other reaction parameters were investigated to provide the most environmentally friendly reaction conditions. The feasibility of scale-up was demonstrated, allowing a simple and inexpensive production of anthranilate esters.
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