Zwitterionic-Type Molten Salt Catalyzed Iodination in Water: Synthesis of Iodoimidazoheterocycles

Abstract

An environmentally benign protocol for the iodination of imidazoheterocycles has been developed through sp² C–H bond functionalization with molecular iodine in water at room temperature. The reaction is catalyzed by an imidazole-based zwitterion-type molten salt. A library of iodo-substituted imidazo[1,2-a]pyridines with broad functionality have been synthesized. This methodology is also applicable to imidazo[2,1-b]thiazole and imidazole scaffolds.

Key words

organocatalyst - zwitterionic salt - imidazoheterocycles - regioselectivity - iodine - water

• References


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