Catalytic Metal-Free Intramolecular Acylcyanation: Synthesis of Functionalized Pyridine Derivatives Bearing Pendent Stereocenters

Abstract

A novel protocol for the synthesis of functionalized pyridines containing quaternary carbon centers through a metal-free catalytic intramolecular acylcyanation approach has been developed. Broad scope, versatility, and efficiency of the process was demonstrated.

Key words

catalysis - acylcyanation - metal-free reaction - pyridine - one-pot reaction

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