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Journal of Pediatric Neuroradiology 2015; 04(01): 011-013
DOI: 10.1055/s-0035-1564664
Case Report
Georg Thieme Verlag KG Stuttgart • New York

Mega Corpus Callosum in a Patient with Macrocephaly and Focal Motor Delay

James Park
1   Department of Radiology, St. Luke's-Roosevelt Hospital Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States
,
Kevin Khodabakhsh
2   Department of Pediatric Neurology, Jamaica Hospital Medical Center, New York, New York, United States
,
Gordon Heller
1   Department of Radiology, St. Luke's-Roosevelt Hospital Center, Icahn School of Medicine at Mount Sinai, New York, New York, United States
› Author Affiliations
Further Information

Publication History

26 June 2013

15 January 2015

Publication Date:
30 September 2015 (online)

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Abstract

An enlarged corpus callosum is a rare entity, with extremely low rates documented in literature. When paired with macrocephaly, only a handful of cases without any other underlying systemic condition are known to exist. We present a novel case of a macrocephalic patient with magnetic resonance imaging findings of an enlarged (or mega) corpus callosum. Neurologic exam demonstrated right lower extremity hypertonicity without any other developmental disorder. It is important to be aware of an enlarged corpus callosum as it may be associated with an underlying motor disorder.

Keywords

corpus callosum - magnetic resonance imaging - macrocephaly
 

  • References

  • 1 Göçmen R, Oğuz KK. Mega corpus callosum and caudate nuclei with bilateral hippocampal malformation. Diagn Interv Radiol 2008; 14 (2) 69-71
    PubMedSearch in Google Scholar
  • 2 Pierson TM, Zimmerman RA, Tennekoon GI, Bönnemann CG. Mega-corpus callosum, polymicrogyria, and psychomotor retardation: confirmation of a syndromic entity. Neuropediatrics 2008; 39 (2) 123-127
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Hengst M, Tücke J, Zerres K, Blaum M, Häusler M. Megalencephaly, mega corpus callosum, and complete lack of motor development: delineation of a rare syndrome. Am J Med Genet A 2010; 152A (9) 2360-2364
    CrossrefPubMedSearch in Google Scholar
  • 4 Göhlich-Ratmann G, Baethmann M, Lorenz P , et al. Megalencephaly, mega corpus callosum, and complete lack of motor development: a previously undescribed syndrome. Am J Med Genet 1998; 79 (3) 161-167
    CrossrefPubMedSearch in Google Scholar
  • 5 Iai M, Tanabe Y, Goto M, Sugita K, Niimi H. A comparative magnetic resonance imaging study of the corpus callosum in neurologically normal children and children with spastic diplegia. Acta Paediatr 1994; 83 (10) 1086-1090
    CrossrefPubMedSearch in Google Scholar
  • 6 Kivitie-Kallio S, Autti T, Salonen O, Norio R. MRI of the brain in the Cohen syndrome: a relatively large corpus callosum in patients with mental retardation and microcephaly. Neuropediatrics 1998; 29 (6) 298-301
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Dubovsky EC, Booth TN, Vezina G, Samango-Sprouse CA, Palmer KM, Brasseux CO. MR imaging of the corpus callosum in pediatric patients with neurofibromatosis type 1. AJNR Am J Neuroradiol 2001; 22 (1) 190-195
    PubMedSearch in Google Scholar
  • 8 Dagli AI, Stalker HJ, Williams CA. A patient with the syndrome of megalencephaly, mega corpus callosum and complete lack of motor development. Am J Med Genet A 2008; 146A (2) 204-207
    CrossrefPubMedSearch in Google Scholar