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Synthesis 2017; 49(12): 2733-2742
DOI: 10.1055/s-0036-1558973
DOI: 10.1055/s-0036-1558973
paper
Development of a Method for the Synthesis of 4-Aryl-Functionalized 2-Azabicyclo[3.2.1]octanes
Further Information
Publication History
Received: 26 January 2017
Accepted after revision: 28 February 2017
Publication Date:
23 March 2017 (online)
Abstract
A method for the synthesis of 4-substituted azabicyclo[3.2.1]octanes from N-tosyl-2-azabicyclo[3.2.1]octa-3,6-diene, a versatile bicyclic heterocycle not commonly used in medicinal chemistry research, is presented. The method uses bromination, followed by Suzuki coupling, and subsequent reduction and deprotection. The desired 4-substituted azabicyclo[3.2.1]octanes were obtained in moderate to high yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1558973.
- Supporting Information
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