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Am J Perinatol 2016; 33(12): 1145-1151
DOI: 10.1055/s-0036-1585085
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Randomized Clinical Trial of an Intensive Behavior Education Program in Gestational Diabetes Mellitus Women Designed to Improve Glucose Levels on the 2-Hour Oral Glucose Tolerance Test

Authors

  • Celeste P. Durnwald

    1   Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Michael J. Kallan

    2   Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Kelly C. Allison

    3   Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Mary D. Sammel

    2   Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Susan Wisch

    1   Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Michal Elovitz

    1   Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

  • Samuel Parry

    1   Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Further Information

Publication History

25 May 2016

28 May 2016

Publication Date:
11 July 2016 (online)

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Abstract

Objective To evaluate whether women with gestational diabetes mellitus (GDM) enrolled in an intensive behavior education program (IBEP) demonstrate lower mean fasting glucose levels on the 2-hour 75 g oral glucose tolerance test (2-hour OGTT) at 6 to 12 weeks postpartum compared with women who undergo routine GDM management.

Study Design A prospective randomized controlled trial of women diagnosed with GDM was conducted. Exclusion criteria were GDM diagnosis ≥ 33 weeks or < 20 weeks. Women were randomly assigned to one of two treatment arms: (1) routine GDM management or (2) an IBEP. Women underwent a 2-hour OGTT at 6 to 12 weeks postpartum. Fisher exact test, t-test, and Wilcoxon rank sum test were used as appropriate.

Results Of the 101 women randomized, 49 were assigned to IBEP and 52 received routine GDM management. There was no difference in mean fasting and 2-hour glucose levels on the postpartum 2-hour OGTT between the IBEP and routine management group (88.5 ± 22.9 mg/dL vs. 85.2 ± 13.3 mg/dL, p = 0.49 and 109.8 ± 38.5 mg/dL vs. 109.4 ± 40.8 mg/dL, p = 0.97, respectively).

Conclusion GDM women enrolled in a healthy lifestyle intervention program did not demonstrate lower glucose values on the postpartum 2-hour OGTT.

Keywords

gestational diabetes mellitus - lifestyle intervention - 2-hour oral glucose tolerance test - impaired glucose tolerance

Note

The findings of this article were presented at the Society for Maternal-Fetal Medicine's Annual Meeting, oral concurrent session 5: DM and Metabolism on February 5, 2016 and correspond to abstract #973. This abstract was the award-winning abstract for oral concurrent session 5: DM and metabolism. This project received financial support from the Penn Presbyterian George L. and Emily McMichael Harrison Fund for Research in Obstetrics and Gynecology, University of Pennsylvania. This randomized clinical trial was registered at ClinicalTrials.gov. Identifier: NCT01858233.