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Synthesis 2017; 49(03): 604-614
DOI: 10.1055/s-0036-1588299
DOI: 10.1055/s-0036-1588299
paper
Asymmetric Synthesis of 2,3,4-Trisubstituted Piperidines
Further Information
Publication History
Received: 28 June 2016
Accepted after revision: 01 August 2016
Publication Date:
02 September 2016 (online)
Abstract
Two different organocatalytic approaches for the asymmetric synthesis of 2,3,4-trisubstituted piperidines were developed. Both approaches were based on an aza-Michael addition followed by cyclization and gave products in high enantiomeric excess.
Key words
organocatalysis - asymmetric catalysis - trisubstituted piperidines - aza-Michael addition - cyclizationSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588299.
- Supporting Information
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