H₂SO₄-Mediated Intramolecular Cyclization of N-Arylated Homoallylamines: A Solvent-Free, Atom- and Step-Economical Synthesis of Tetrahydro-1-benzazepines

Abstract

The biologically important tetrahydro-1-benzazepine skeleton was conveniently constructed from N-arylated homoallylamines through H₂SO₄-mediated intramolecular cyclization. The advantages of this transformation include mild reaction conditions, experimental simplicity, its solvent- and metal-free, atom- and step-economical nature, and the use of a readily available, cheap, and nontoxic mediator.

Key words

cyclization - alkylation - solvent-free - metal-free - sulfuric acid

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