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Synthesis 2017; 49(18): 4173-4182
DOI: 10.1055/s-0036-1588416
DOI: 10.1055/s-0036-1588416
special topic
One-Pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes via a Mercury-Carbene Intermediate
We are grateful to the Ministry of Science and Technology of the People’s Republic of China (2016YFA0602900), the NSFC (21372086, 21422204, and 21672071), Guangdong NSF (2014A030313229, 2016A030310433), and the Fundamental Research Funds for the Central Universities, SCUT.Weitere Informationen
Publikationsverlauf
Received: 18. März 2017
Accepted after revision: 10. April 2017
Publikationsdatum:
15. Mai 2017 (online)
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
Abstract
The cyclization of nitroalkyne catalyzed by Hg(OTf)2 to produce the corresponding benzo[c]isoxazole in excellent yields with high selectivity is reported. On the basis of this strategy, a one-pot method to synthesize indole derivatives has been developed. In this transformation, two Hg-carbene intermediates are proposed to be involved.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588416.
- Supporting Information
- CIF File
-
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