Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides

Dedicated to Professor Teruaki Mukaiyama in celebration of his 90^th birthday (Sotsuju­)
Published as part of the Special Topic Advanced Strategies in Synthesis with Nickel

Abstract

A nickel-catalyzed cross-electrophile coupling of aryl triflates and nonaflates with alkyl iodides using manganese(0) as a reductant is described. The method is applicable to the reductive alkylation of various aryl sulfonates, including o-borylaryl triflate, which enabled efficient construction of diverse alkylated arenes under mild conditions.

Key words

reductive alkylation - cross-electrophile coupling - nickel catalysis­ - aryl triflate - alkyl iodide - aromatic compounds

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