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Synthesis 2017; 49(07): 1664-1674
DOI: 10.1055/s-0036-1588672
DOI: 10.1055/s-0036-1588672
paper
Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams
Further Information
Publication History
Received: 17 October 2016
Accepted after revision: 14 November 2016
Publication Date:
16 December 2016 (online)
Abstract
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, γ-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol is simple, general, and allows one-pot access to a range of drugs and bioactive small molecules.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588672.
- Supporting Information
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References
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TFE is often seen to improve the yield of Ugi type reactions, see for example:
Isocyanide additions are notoriously poorly diastereoselective, see: