Dedicated to Professor Armin de Meijere for his great achievements in the field of
cyclocarbopalladation in cascade reactions
Abstract
Cascade reactions are step-economical processes for the synthesis of complex molecules
as they allow, in one step, the formation of multiple bonds. Over the last two decades
cyclocarbopalladation has emerged as a powerful key step when integrated into these
sequences and has allowed unprecedented valuable polycyclic scaffolds to be obtained.
This review is focused on recent developments in this field including original cascade
sequences, novel activation modes (C–H activation for instance) and unprecedented
families of substrates.
1 Introduction
2 Formation of Carbocycles
2.1 4-exo Cyclocarbopalladation
2.2 5-exo Cyclocarbopalladation
2.3 5-endo Cyclocarbopalladation
2.4 Cyclocarbopalladation with Formation of Six-Membered Carbocycles
2.5 Cyclocarbopalladation with Formation of Seven-Membered Carbocycles
3 Formation of Heterocycles
3.1 Formation of Nitrogen Heterocycles
3.2 Formation of Oxygen Heterocycles
3.3 Formation of Sulfur Heterocycles
3.4 Formation of Silicon-Containing Heterocycles
4 Conclusion
Key words
cyclocarbopalladation - cyclic compounds - carbocycles - heterocycles - palladium
- cyclization - domino - cascade
