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Synthesis 2017; 49(10): 2241-2249
DOI: 10.1055/s-0036-1588717
DOI: 10.1055/s-0036-1588717
paper
Synthesis of Polyfunctionalized Pyrroles from Furfurylamines and Ynones via CuCl2-Catalyzed and Iodine-Mediated Oxidative Annulation of N-Furfuryl-β-Enaminones
Further Information
Publication History
Received: 05 January 2017
Accepted after revision: 23 January 2017
Publication Date:
16 February 2017 (online)
Abstract
The copper chloride catalyzed and iodine-mediated oxidative annulation of N-furfuryl-β-enaminones, generated in situ from reactions of furfurylamines with ynones, provides a practical access to polyfunctionalized pyrroles under mild conditions. This protocol expands the synthetic application of furans, which are readily available and can be sustainably sourced.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588717.
- Supporting Information
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For selected examples of synthetic applications of pyrroles, see:
For a selection of recent pyrrole syntheses, see:
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For recent reviews, see:
For recent selected examples, see: