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Synthesis 2017; 49(18): 4292-4298
DOI: 10.1055/s-0036-1588876
DOI: 10.1055/s-0036-1588876
special topic
Facile Construction of Pyrrolo[1,2-a]indolenine Scaffold via Diastereoselective [3+2] Annulation of Donor–Acceptor Cyclopropane with Indolenine
We gratefully acknowledge the financial support from the National Natural Science Foundation of China (No. 21576296) and Central South University.Further Information
Publication History
Received: 11 April 2017
Accepted after revision: 15 May 2017
Publication Date:
19 July 2017 (online)
Published as part of the Special Topic Modern Cyclization Strategies in Synthesis
Abstract
A novel synthetic protocol for the assembly of pyrrolo[1,2-a]indolenine has been developed through a highly diastereoselective [3+2] annulation of 1,1-cyclopropanediesters with indolenines in the presence of catalytic Yb(OTf)3. This new strategy allows a facile construction of the multicyclic system with the flexible variation on the substituents in high yields (up to 86%) with excellent diastereoselectivities (>20:1 dr) in most cases.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588876.
- Supporting Information
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