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Synthesis 2017; 49(04): 763-769
DOI: 10.1055/s-0036-1588886
DOI: 10.1055/s-0036-1588886
paper
Multicomponent Approach for the Synthesis of Substituted 1,8-Naphthyridine Derivatives Catalyzed by N-Bromosulfonamides
Further Information
Publication History
Received: 11 July 2016
Accepted after revision: 30 August 2016
Publication Date:
28 September 2016 (online)
Abstract
A single-step, facile synthesis of new 1,8-naphthyridine derivatives was carried out at room temperature under mild conditions using a three-component condensation reaction of substituted 2-aminopyridines, malononitrile or methyl/ethyl cyanoacetate, and various aldehydes in the presence of N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide (TBBDA) or poly(N,N′-dibromo-N-ethylbenzene-1,3-disulfonamide) (PBBS) as Lewis acid. A simple procedure, good to high yields, easy workup, and purification and reusability of the catalyst are significant advantages of this process.
Key words
1,8-naphthyridine - N-bromosulfonamides - 2-aminopyridine - Knoevenagel/Michael addition - heterocyclization - MCRSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588886.
- Supporting Information
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