Development of Chalcogenide Catalysts towards Trifluoromethylthiolation

Jie Luo; Xiang Liu; Xiaodan Zhao

doi:10.1055/s-0036-1588926

Synlett, Inhaltsverzeichnis

Synlett 2017; 28(04): 397-401
DOI: 10.1055/s-0036-1588926

synpacts

Development of Chalcogenide Catalysts towards Trifluoromethylthiolation

Jie Luo

Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. of China eMail: zhaoxd3@mail.sysu.edu.cn

,

Xiang Liu

Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. of China eMail: zhaoxd3@mail.sysu.edu.cn

,

Xiaodan Zhao*

Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. of China eMail: zhaoxd3@mail.sysu.edu.cn

› Institutsangaben

Abstract

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Abstract

Efficient synthesis of trifluoromethylthiolated molecules, especially for chiral ones, is in great demand for the development of drugs. Developing new catalysis mode and new catalysts is the key to quickly expand this area. Our group discovered that Lewis basic chalcogenide catalysts could activate the N–SCF₃ bond, which provided a new way for non- and asymmetric trifluoromethylthiolation. This Synpacts article highlights the recent advances we have achieved.

1 Introduction

2 Selenide-Catalyzed Nonasymmetric Trifluoromethylthiolation

3 Chiral Sulfide-Catalyzed Enantioselective Trifluoromethylthiolation

4 Conclusion

Key words

trifluoromethylthiolation - organocatalysis - Lewis base catalysis - asymmetric catalysis - selenides - sulfides - alkenes

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Referenzen

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