Development of Chalcogenide Catalysts towards Trifluoromethylthiolation

Abstract

Efficient synthesis of trifluoromethylthiolated molecules, especially for chiral ones, is in great demand for the development of drugs. Developing new catalysis mode and new catalysts is the key to quickly expand this area. Our group discovered that Lewis basic chalcogenide catalysts could activate the N–SCF₃ bond, which provided a new way for non- and asymmetric trifluoromethylthiolation. This Synpacts article highlights the recent advances we have achieved.

1 Introduction

2 Selenide-Catalyzed Nonasymmetric Trifluoromethylthiolation

3 Chiral Sulfide-Catalyzed Enantioselective Trifluoromethylthiolation

4 Conclusion

Key words

trifluoromethylthiolation - organocatalysis - Lewis base catalysis - asymmetric catalysis - selenides - sulfides - alkenes

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