2-(Aminomethyl)-3-arylindoles from 3-(o-Trifluoroacetamidoaryl)-1-propargylic Alcohols, Aryl Halides, and Amines: A Domino Palladium-Catalyzed Three-Component Approach

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

A simple, straightforward palladium-catalyzed approach to 2-(aminomethyl)-3-arylindoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols, amines, and aryl iodides has been developed.

Key words

2-(aminomethyl)indoles - palladium - domino reaction - multicomponent reaction - cyclization - 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols

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