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Synthesis 2018; 50(02): 241-253
DOI: 10.1055/s-0036-1590915
DOI: 10.1055/s-0036-1590915
short review
Recent Advances in the Synthesis of Benzimidazole Derivatives from the Oxidative Coupling of Primary Amines
Further Information
Publication History
Received: 30 August 2017
Accepted after revision: 01 September 2017
Publication Date:
21 September 2017 (online)
Abstract
Benzimidazole belongs to the top five most commonly used five-membered aromatic nitrogen heterocycles among U.S. FDA approved pharmaceuticals. Over the last few years, a large number of improved synthetic strategies have been developed to construct the benzimidazole molecular framework under environmentally benign conditions. This review focuses on the use of primary amines as readily available substrates for the synthesis of benzimidazole derivatives through different types of oxidative cross-coupling reactions.
1 Introduction
2 Catalyst-Free Oxidative Coupling of Primary Amines
3 Catalytic Oxidative Coupling of Primary Amines
3.1 Metal-Catalyzed Reactions
3.2 Metal-Free Catalyzed Reactions
3.3 Bioinspired Catalyzed Reactions
4 Conclusion
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