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Synthesis 2018; 50(02): 341-348
DOI: 10.1055/s-0036-1590934
DOI: 10.1055/s-0036-1590934
paper
One-Pot Assembly towards ω-Substituted Arylbiurets from Aromatic Amines, Potassium Cyanate, and Glacial Acetic Acid
This work was supported financially by the State Key Laboratory of Fine Chemicals (Panjin) (Grant No. JH2014009) project and the Fundamental Research Funds for the Central Universities.Further Information
Publication History
Received: 10 July 2017
Accepted after revision: 13 September 2017
Publication Date:
23 October 2017 (online)
Abstract
A novel, simple, and highly efficient method has been designed for the synthesis of ω-substituted arylbiurets in a one-pot reaction. The primary features of this protocol include readily available starting materials, an easy work-up procedure, and yields of 51 to 87%. ω-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN). However, use of an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.
Key words
ω-substituted biuret - N-monosubstituted urea - potassium cyanate - dicyanic acid - selective reactionsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1590934.
- Supporting Information
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