One-Pot Assembly towards ω-Substituted Arylbiurets from ­Aromatic Amines, Potassium Cyanate, and Glacial Acetic Acid

Abstract

A novel, simple, and highly efficient method has been designed for the synthesis of ω-substituted arylbiurets in a one-pot reaction. The primary features of this protocol include readily available starting materials, an easy work-up procedure, and yields of 51 to 87%. ω-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN). However, use of an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.

Key words

ω-substituted biuret - N-monosubstituted urea - potassium cyanate - dicyanic acid - selective reactions

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