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Synthesis 2018; 50(09): 1901-1906
DOI: 10.1055/s-0036-1591769
DOI: 10.1055/s-0036-1591769
paper
Stereoselective Synthesis of Northern Fragment of Eribulin Mesylate from d-Mannose
GV thanks DST New Delhi for INSPIRE Faculty Award (IFA14-CH-158). SC thanks Science and Engineering Research Board, Department of Science and Technology for a research grant (SB/S2/JCB-002/2015). The authors thank Council of Scientific and Industrial Research, Department of Science and Technology, Govt. of India, for research grant.Weitere Informationen
Publikationsverlauf
Received: 14. Dezember 2017
Accepted after revision: 01. Februar 2018
Publikationsdatum:
21. Februar 2018 (online)
Abstract
Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then Dess–Martin periodinane oxidation followed by samarium(II) iodide mediated desulfonylation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591769.
- Supporting Information
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