The Pursuit of Noninvasive Diagnosis of Lung Cancer

Thomas Atwater; Christine M. Cook; Pierre P. Massion

doi:10.1055/s-0036-1592314

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2016; 37(05): 670-680
DOI: 10.1055/s-0036-1592314

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Pursuit of Noninvasive Diagnosis of Lung Cancer

Thomas Atwater

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

,

Christine M. Cook

¹Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

,

Pierre P. Massion

²Cornelius Vanderbilt Endowed Chair in Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

³Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee

› Author Affiliations

Abstract

The noninvasive diagnosis of lung cancer remains a formidable challenge. Although tissue diagnosis will remain the gold standard for the foreseeable future, questions pertaining to the risks and costs associated with invasive diagnostic procedures are of prime relevance. This review addresses new modalities for improving the noninvasive evaluation of suspicious lung nodules. Ultimately, the goal is to translate early diagnosis into early treatment. We discuss how biomarkers could assist in distinguishing benign from malignant nodules and aggressive from indolent tumors. The field of biomarkers is rapidly expanding and progressing, and efforts are well underway to apply molecular diagnostics to address the shortcomings of current lung cancer diagnostic tools.

Keywords

early detection - clinical utility - biomarkers - indeterminate pulmonary nodule

Full Text

References

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